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Real-World Evidence for the Association Between Pneumonia-Related Intensive Care Unit Stay and Dementia

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Objective There is limited clarity concerning the risk of dementia after pneumonia with intensive care unit (ICU) stay. We conducted a nationwide cohort study, which aimed to investigate the impact of dementia after pneumonia with and without intensive care unit admission.Methods Data was obtained from Taiwan’s National Health Insurance Research Database between 2000 and 2015. A total of 7,473 patients were identified as having pneumonia required ICU stay, along with 22,419 controls matched by sex and age. After adjusting for confounding factors, multivariate Cox regression model analysis was used to compare the risk of developing dementia during the 15-years follow-up period.Results The enrolled pneumonia patients with ICU admission had a dementia rate of 9.89%. Pneumonia patients without ICU admission had a dementia rate of 9.21%. The multivariate Cox regression model analysis revealed that the patients with ICU stay had the higher risk of dementia, with a crude hazard ratio of 3.371 (95% confidence interval, 3.093–3.675; p<0.001).Conclusion This study indicated that pneumonia with ICU stay is associated with an increased risk of dementia. A 3-fold risk of dementia was observed in patients admitted to the ICU compared to the control group.

Abstract

Objective There is limited clarity concerning the risk of dementia after pneumonia with intensive care unit (ICU) stay. We conducted a nationwide cohort study, which aimed to investigate the impact of dementia after pneumonia with and without intensive care unit admission.Methods Data was obtained from Taiwan’s National Health Insurance Research Database between 2000 and 2015. A total of 7,473 patients were identified as having pneumonia required ICU stay, along with 22,419 controls matched by sex and age. After adjusting for confounding factors, multivariate Cox regression model analysis was used to compare the risk of developing dementia during the 15-years follow-up period.Results The enrolled pneumonia patients with ICU admission had a dementia rate of 9.89%. Pneumonia patients without ICU admission had a dementia rate of 9.21%. The multivariate Cox regression model analysis revealed that the patients with ICU stay had the higher risk of dementia, with a crude hazard ratio of 3.371 (95% confidence interval, 3.093–3.675; p<0.001).Conclusion This study indicated that pneumonia with ICU stay is associated with an increased risk of dementia. A 3-fold risk of dementia was observed in patients admitted to the ICU compared to the control group.

참고문헌 (51)

  1. Chou CC, "Recommendations and guidelines for the treatment of pneumonia in Taiwan", J Microbiol Immunol Infect, 52, pp.172~199 (2019)
  2. Marrie TJ, "A controlled trial of a critical pathway for treatment of community-acquired pneumonia. CAPITAL study investigators. Communityacquired pneumonia intervention trial assessing levofloxacin", JAMA, 283, pp.749~755 (2000)
  3. Edition F, "Diagnostic and statistical manual of mental disorders", Am Psychiatric Assoc, 21, pp.591~643 (2013)
  4. Mitchell SL, "Advanced dementia", N Engl J Med, 372, pp.2533~2540 (2015)
  5. Tzeng NS, "Caregiver burden for patients with dementia with or without hiring foreign health aides: a cross-sectional study in a northern taiwan memory clinic", J Med Sci, 35, pp.239~ (2015)
  6. Chang SY, "Risk of dementia after charcoal-burning suicide attempts: a nationwide cohort study in Taiwan", J Investig Med, 66, pp.1070~1082 (2018)
  7. Shah FA, "Bidirectional relationship between cognitive function and pneumonia", Am J Respir Crit Care Med, 188, pp.586~592 (2013)
  8. Naruishi K, "Relationship of aspiration pneumonia to cognitive impairment and oral condition: a cross-sectional study", Clin Oral Investig, 22, pp.2575~2580 (2018)
  9. Pisani MA, "Cognitive impairment in the intensive care unit", Clin Chest Med, 24, pp.727~737 (2003)
  10. Tate JA, "Infection hospitalization increases risk of dementia in the elderly", Crit Care Med, 42, pp.1037~1046 (2014)
  11. Girard TD, "Long-term cognitive impairment after hospitalization for community-acquired pneumonia: a prospective cohort study", J Gen Intern Med, 33, pp.929~935 (2018)
  12. Ahlström B, "A nationwide study of the long-term prevalence of dementia and its risk factors in the Swedish intensive care cohort", Crit Care, 24, pp.548~ (2020)
  13. Lai CC, "Longterm risk of dementia after acute respiratory failure requiring intensive care unit admission", PLoS One, 12, pp.e0180914~ (2017)
  14. Ho Chan WS, "Taiwan’s healthcare report 2010", EPMA J, 1, pp.563~585 (2010)
  15. Liu YP, "Are anticholinergic medications associated with increased risk of dementia and behavioral and psychological symptoms of dementia? A nationwide 15-year follow-up cohort study in Taiwan", Front Pharmacol, 11, pp.30~ (2020)
  16. Chao PC, "Cognitive enhancers associated with decreased risk of injury in patients with dementia: a nationwide cohort study in Taiwan", J Investig Med, 66, pp.684~692 (2018)
  17. Chen KC, "Association between the use of dipeptidyl peptidase 4 inhibitors and the risk of dementia among patients with type 2 diabetes in Taiwan", J Clin Med, 9, pp.660~ (2020)
  18. Chiou YE, "New users of herbal medicine containing aristolochic acids and the risk of dementia in the elderly: a nationwide, population-based study in Taiwan", Neuropsychiatr Dis Treat, 16, pp.1493~1504 (2020)
  19. Chu CW, "Electroconvulsive therapy and risk of dementia—a nationwide cohort study in Taiwan", Front Psychiatry, 9, pp.397~ (2018)
  20. Lin CH, "Increased risk of dementia in patients with genital warts: a nationwide cohort study in Taiwan", J Dermatol, 47, pp.503~511 (2020)
  21. Tzeng NS, "Association between amphetamine-related disorders and dementia-a nationwide cohort study in Taiwan", Ann Clin Transl Neurol, 7, pp.1284~1295 (2020)
  22. Tzeng NS, "Anti-herpetic medications and reduced risk of dementia in patients with herpes simplex virus infections—a nationwide, population-based cohort study in Taiwan", Neurotherapeutics, 15, pp.417~429 (2018)
  23. Tzeng NS, "Magnesium oxide use and reduced risk of dementia: a retrospective, nationwide cohort study in Taiwan", Curr Med Res Opin, 34, pp.163~169 (2018)
  24. Tzeng NS, "Headaches and risk of dementia", Am J Med Sci, 353, pp.197~206 (2017)
  25. Tzeng NS, "Risk of dementia in adults with ADHD: a nationwide, population-based cohort study in Taiwan", J Atten Disord, 23, pp.995~1006 (2019)
  26. Tzeng NS, "Fibromyalgia and risk of dementia—a nationwide, population-based, cohort study", Am J Med Sci, 355, pp.153~161 (2018)
  27. Tzeng NS, "Are chronic periodontitis and gingivitis associated with dementia? A nationwide, retrospective, matched-cohort study in Taiwan", Neuroepidemiology, 47, pp.82~93 (2016)
  28. Wang JC, "Surgical repair of aortic aneurysms and reduced incidence of dementia", Int J Cardiol, 278, pp.46~50 (2019)
  29. Yang CC, "No association between human immunodeficiency virus infections and dementia: a nationwide cohort study in Taiwan", Neuropsychiatr Dis Treat, 15, pp.3155~3166 (2019)
  30. Chang CY, "Increased risk of major depression in the three years following a femoral neck fracture--a national population-based follow-up study", PLoS One, 9, pp.e89867~ (2014)
  31. Volicer L, "Effects of continuous activity programming on behavioral symptoms of dementia", J Am Med Dir Assoc, 7, pp.426~431 (2006)
  32. McCoy JG, "One week of exposure to intermittent hypoxia impairs attentional set-shifting in rats", Behav Brain Res, 210, pp.123~126 (2010)
  33. Yaffe K, "Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women", JAMA, 306, pp.613~619 (2011)
  34. Taccone FS, "Sepsis is associated with altered cerebral microcirculation and tissue hypoxia in experimental peritonitis", Crit Care Med, 42, pp.e114~e122 (2014)
  35. Kellum JA, "Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the genetic and inflammatory markers of sepsis (Gen-IMS) study", Arch Intern Med, 167, pp.1655~1663 (2007)
  36. Yaffe K, "The metabolic syndrome, inflammation, and risk of cognitive decline", JAMA, 292, pp.2237~2242 (2004)
  37. Leonard BE, "Inflammation, depression and dementia: are they connected?", Neurochem Res, 32, pp.1749~1756 (2007)
  38. d’Avila JC, "Sepsis induces brain mitochondrial dysfunction", Crit Care Med, 36, pp.1925~1932 (2008)
  39. van Gool WA, "Systemic infection and delirium: when cytokines and acetylcholine collide", Lancet, 375, pp.773~775 (2010)
  40. Cunningham C, "Systemic inflammation and delirium: important cofactors in the progression of dementia", Biochem Soc Trans, 39, pp.945~953 (2011)
  41. Sun Y, "A nationwide survey of mild cognitive impairment and dementia, including very mild dementia, in Taiwan", PLoS One, 9, pp.e100303~ (2014)
  42. Liu HC, "Prevalence and subtypes of dementia in Taiwan: a community survey of 5297 individuals", J Am Geriatr Soc, 43, pp.144~149 (1995)
  43. Liu CK, "Incidence and subtypes of dementia in southern Taiwan: impact of socio-demographic factors", Neurology, 50, pp.1572~1579 (1998)
  44. Jia J, "The prevalence of dementia in urban and rural areas of China", Alzheimers Dement, 10, pp.1~9 (2014)
  45. Xu H, "The impact of residential status on cognitive decline among older adults in China: results from a longitudinal study", BMC Geriatr, 17, pp.107~ (2017)
  46. Chen H, "Living near major roads and the incidence of dementia, Parkinson’s disease, and multiple sclerosis: a population-based cohort study", Lancet, 389, pp.718~726 (2017)
  47. Su VY, "Sleep apnea and risk of pneumonia: a nationwide population-based study", CMAJ, 186, pp.415~421 (2014)
  48. Su VY, "Use of ICS", LABA combinations or LAMA is associated with a lower risk of acute exacerbation in patients with coexistent COPD and asthma, 2018, pp.6, 1927~1935.e3
  49. Su VY, "Statin use is associated with a lower risk of TB", Chest, 152, pp.598~606 (2017)
  50. Wu CS, "Using text mining to extract depressive symptoms and to validate the diagnosis of major depressive disorder from electronic health records", J Affect Disord, 260, pp.617~623 (2020)
  51. Guevara RE, "Accuracy of ICD-9-CM codes in detecting community-acquired pneumococcal pneumonia for incidence and vaccine efficacy studies", Am J Epidemiol, 149, pp.282~289 (1999)

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