Suicide Risk in Patients With Diabetes Varies by the Duration of Diabetes: The Korea National Health and Nutrition Examination Survey (2019)
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objective The objectives of this study were to investigate the suicide risk in diabetes patients and evaluate the variations in suicide risk by the duration of diabetes using a large population sample in South Korea.Methods Data from 6,296 adults in the 2019 Korea National Health and Nutrition Examination Survey were included. The suicidal ideation, suicide plans, and suicidal behavior of diabetes patients were compared to the general population. After classifying the patients into ≤1 year, 2 to 9 years, and ≥10 years of diabetes duration, we evaluated the relationship between the duration of diabetes and the suicide risk.Results Diabetes patients had higher prevalences of suicidal ideation (9.1%, p<0.001) and suicide plans (3.6%, p<0.001) than the general population. After adjusting for potential confounding factors, suicide plans (adjusted odds ratio [aOR]=2.926, 95% confidence interval [CI]=1.325–6.463) were significantly associated with diabetes. In the 2 to 9 years group of diabetes patients, we found an increase in the risk of suicidal ideation (aOR=2.035, 95% CI=1.129–3.670), suicide plans (aOR=3.507, 95% CI=1.538–7.996), and suicidal behavior (aOR=7.130, 95% CI=2.035–24.978) after adjusting for the covariates. However, no increases in suicide risk were observed ≤1 year and ≥10 years after diabetes diagnosis.Conclusion In adults, diabetes is associated with an increase in suicide risk. Suicide risk in diabetes patients showed an inverted U-shaped depending upon the duration of diabetes.
Abstract
Objective The objectives of this study were to investigate the suicide risk in diabetes patients and evaluate the variations in suicide risk by the duration of diabetes using a large population sample in South Korea.Methods Data from 6,296 adults in the 2019 Korea National Health and Nutrition Examination Survey were included. The suicidal ideation, suicide plans, and suicidal behavior of diabetes patients were compared to the general population. After classifying the patients into ≤1 year, 2 to 9 years, and ≥10 years of diabetes duration, we evaluated the relationship between the duration of diabetes and the suicide risk.Results Diabetes patients had higher prevalences of suicidal ideation (9.1%, p<0.001) and suicide plans (3.6%, p<0.001) than the general population. After adjusting for potential confounding factors, suicide plans (adjusted odds ratio [aOR]=2.926, 95% confidence interval [CI]=1.325–6.463) were significantly associated with diabetes. In the 2 to 9 years group of diabetes patients, we found an increase in the risk of suicidal ideation (aOR=2.035, 95% CI=1.129–3.670), suicide plans (aOR=3.507, 95% CI=1.538–7.996), and suicidal behavior (aOR=7.130, 95% CI=2.035–24.978) after adjusting for the covariates. However, no increases in suicide risk were observed ≤1 year and ≥10 years after diabetes diagnosis.Conclusion In adults, diabetes is associated with an increase in suicide risk. Suicide risk in diabetes patients showed an inverted U-shaped depending upon the duration of diabetes.
참고문헌 (36)
- Depression and other common mental disorders: global health estimates, "World Health Organization", World Health Organization, ~ (2017)
- 통계청 인구동향과, "2018년 사망원인통계", 대한의사협회지, 63(5), pp.286~297 (2020), 대한의사협회
- Suicide in the world: global health estimates, "World Health Organization", World Health Organization, ~ (2019)
- Yumi Lee, "Gender-based Multilevel Analysis of Influential Factors for Suicide Attempts among At-risk Non-referred Adolescents in Korea", Clinical Psychopharmacology and Neuroscience, 18(1), pp.116~126 (2020), 대한정신약물학회[DOI]
- Sheng Min Wang, "Rapid Onset of Intranasal Esketamine in Patients with Treatment Resistant Depression and Major Depression with Suicide Ideation: A Meta-Analysis", Clinical Psychopharmacology and Neuroscience, 19(2), pp.341~354 (2021), 대한정신약물학회[DOI]
- Olfson M, "Focusing suicide prevention on periods of high risk", JAMA, 311, pp.1107~1108 (2014)
- Clarke DM, "Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence", Med J Aust, 190, pp.S54~S60 (2009)
- 정찬희, "Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status", Diabetes and Metabolism Journal, 45(1), pp.1~10 (2021), 대한당뇨병학회[DOI]
- Roy T, "Epidemiology of depression and diabetes: a systematic review", J Affect Disord, 142, pp.S8~S21 (2012)
- Golden SH, "Examining a bidirectional association between depressive symptoms and diabetes", JAMA, 299, pp.2751~2759 (2008)
- Goldney RD, "Diabetes, depression, and quality of life: a population study", Diabetes Care, 27, pp.1066~1070 (2004)
- Holt RI, "The relationship between depression and diabetes mellitus: findings from the Hertfordshire Cohort Study", Diabet Med, 26, pp.641~648 (2009)
- Darwish L, "Depression in people with type 2 diabetes: current perspectives", Diabetes Metab Syndr Obes, 11, pp.333~343 (2018)
- Anderson RJ, "The prevalence of comorbid depression in adults with diabetes: a meta-analysis", Diabetes Care, 24, pp.1069~1078 (2001)
- Pompili M, "Suicide risk in type 1 diabetes mellitus: a systematic review", J Psychosom Res, 76, pp.352~360 (2014)
- Kim HJ, "The association of diabetes duration and glycemic control with depression in elderly men with type 2 diabetes mellitus", J Res Med Sci, 24, pp.17~ (2019)
- Almeida OP, "Duration of diabetes and its association with depression in later life: the health in men study (HIMS)", Maturitas, 86, pp.3~9 (2016)
- Tabb KM, "The burden of suicidal ideation among persons with type II diabetes: a scoping review", J Psychosom Res, 103, pp.113~118 (2017)
- Chung JH, "Suicidal ideation and suicide attempts among diabetes mellitus: the Korea National Health and Nutrition Examination Survey (KNHANES IV, V)from 2007 to 2012", J Psychosom Res, 77, pp.457~461 (2014)
- Kposowa AJ, "Marital status and suicide in the National Longitudinal Mortality Study", J Epidemiol Community Health, 54, pp.254~261 (2000)
- Erlangsen A, "Physical diseases as predictors of suicide in older adults: a nationwide, register-based cohort study", Soc Psychiatry Psychiatr Epidemiol, 50, pp.1427~1439 (2015)
- Hawton K, "Suicide", Lancet, 373, pp.1372~1381 (2009)
- 임미래, "우리나라 자살기도자의 특징", 신경정신의학, 54(2), pp.209~215 (2015), 대한신경정신의학회[DOI]
- 2018 national survey on suicide, "Korea Suicide Prevention Center", Ministry of Health and Welfare, ~ (2019)
- Kruse J, "On the association between diabetes and mental disorders in a community sample: results from the German national health interview and examination survey", Diabetes Care, 26, pp.1841~1846 (2003)
- Rotella F, "Diabetes mellitus as a risk factor for depression. A meta-analysis of longitudinal studies", Diabetes Res Clin Pract, 99, pp.98~104 (2013)
- Nouwen A, "Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis", Diabetologia, 53, pp.2480~2486 (2010)
- Klonsky ED, "Suicide, suicide attempts, and suicidal ideation", Annu Rev Clin Psychol, 12, pp.307~330 (2016)
- Kyrou I, "Stress hormones: physiological stress and regulation of metabolism", Curr Opin Pharmacol, 9, pp.787~793 (2009)
- Webb M, "The association between depressive symptoms and insulin resistance, inflammation and adiposity in men and women", PLoS One, 12, pp.e0187448~ (2017)
- Detka J, "Budziszewska B. Neuroendocrine link between stress, depression and diabetes", Pharmacol Rep, 65, pp.1591~1600 (2013)
- Gold PW, "Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-γ systems", Mol Psychiatry, 18, pp.154~165 (2013)
- Watson KT, "Incident major depressive disorder predicted by three measures of insulin resistance: a Dutch cohort study", Am J Psychiatry, 178, pp.914~920 (2021)
- Jeong E, "Temporal trajectories of accompanying comorbidities in patients with type 2 diabetes:a Korean nationwide observational study", Sci Rep, 10, pp.5535~ (2020)
- Lee HY, "Risk of suicidal ideation in diabetes varies by diabetes regimen, diabetes duration, and HbA1c level", J Psychosom Res, 76, pp.275~279 (2014)
- Chiu CJ, "Psychological prognosis after newly diagnosed chronic conditions: socio-demographic and clinical correlates", Int Psychogeriatr, 29, pp.281~292 (2017)