Risk and Protective Factors for Childhood Physical Abuse and Suicidal Ideation: The Effect of Brain-Derived Neurotrophic Factor Polymorphism and Social Support
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Objective This study aimed to explore the relationship between childhood physical abuse and suicidal ideation considering the effects of genetic and environmental factors in patients with post-traumatic stress disorder (PTSD) by focusing on brain-derived neurotrophic factor (BDNF) polymorphism and social support, respectively.Methods One-hundred fourteen patients with PTSD and 94 healthy controls (HCs) were genotyped with respect to BDNF Val66Met polymorphism. All participants underwent psychological assessments. The hierarchical regression analysis and the simple slope analysis were conducted.Results As for patients with PTSD, the moderation effect of BDNF polymorphism was significant but not for social support. Specifically, the BDNF Val/Val genotype worked as a risk factor and strengthens the relationship between childhood physical abuse and suicidal ideation. As for the HCs, the significant moderation effect was found only in social support, but not for BDNF polymorphism. The relationship between childhood physical abuse and suicidal ideation was weakened for the HCs with high social support.Conclusion This study demonstrated a significant BDNF genetic vulnerability for suicide in patients with PTSD who experienced childhood physical abuse. Our results suggested that social support provided a mitigating effect on the relationship between childhood physical abuse and suicidal ideation only in the HCs.
Abstract
Objective This study aimed to explore the relationship between childhood physical abuse and suicidal ideation considering the effects of genetic and environmental factors in patients with post-traumatic stress disorder (PTSD) by focusing on brain-derived neurotrophic factor (BDNF) polymorphism and social support, respectively.Methods One-hundred fourteen patients with PTSD and 94 healthy controls (HCs) were genotyped with respect to BDNF Val66Met polymorphism. All participants underwent psychological assessments. The hierarchical regression analysis and the simple slope analysis were conducted.Results As for patients with PTSD, the moderation effect of BDNF polymorphism was significant but not for social support. Specifically, the BDNF Val/Val genotype worked as a risk factor and strengthens the relationship between childhood physical abuse and suicidal ideation. As for the HCs, the significant moderation effect was found only in social support, but not for BDNF polymorphism. The relationship between childhood physical abuse and suicidal ideation was weakened for the HCs with high social support.Conclusion This study demonstrated a significant BDNF genetic vulnerability for suicide in patients with PTSD who experienced childhood physical abuse. Our results suggested that social support provided a mitigating effect on the relationship between childhood physical abuse and suicidal ideation only in the HCs.
참고문헌 (66)
- American Psychiatric Association, "Diagnostic and statistical manual of mental disorders" (2013), American Psychiatric Association
- Brodsky BS, "Adverse childhood experiences and suicidal behavior", Psychiatr Clin North Am, 31, pp.223~235 (2008)
- Devries KM, "Intimate partner violence victimization and alcohol consumption in women: a systematic review and meta-analysis", Addiction, 109, pp.379~391 (2014)
- Etain B, "Beyond genetics:childhood affective trauma in bipolar disorder", Bipolar Disord, 10, pp.867~876 (2008)
- Lopez-Castroman J, "Suicidal phenotypes associated with family history of suicidal behavior and early traumatic experiences", J Affect Disord, 142, pp.193~199 (2012)
- Lopez-Castroman J, "Posttraumatic stress disorder following childhood abuse increases the severity of suicide attempts", J Affect Disord, 170, pp.7~14 (2015)
- Nelson EC, "Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: results from a twin study", Arch Gen Psychiatry, 59, pp.139~145 (2002)
- Sugaya L, "Child physical abuse and adult mental health: a national study", J Trauma Stress, 25, pp.384~392 (2012)
- Polyvictimization: children’s exposure to multiple types of violence, crime, and abuse, "Finkelhor D", US Government Printing Office, ~ (2011)
- Rasmussen SA, "Elaborating the cry of pain model of suicidality: testing a psychological model in a sample of first-time and repeat self-harm patients", Br J Clin Psychol, 49(Pt 1), pp.15~30 (2010)
- Joiner TE, "Why people die by suicide" (2005), Harvard University Press
- González-Castro TB, "The role of brain-derived neurotrophic factor (BDNF) Val66Met genetic polymorphism in bipolar disorder: a case-control study, comorbidities, and meta-analysis of 16,786 subjects", Bipolar Disord, 17, pp.27~38 (2015)
- Iga J, "The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients", Am J Med Genet B Neuropsychiatr Genet, 144B, pp.1003~1006 (2007)
- Wang JY, "Association of brain-derived neurotrophic factor G196A and attempted suicide: a case-control study in rural China", Neuropsychobiology, 72, pp.91~96 (2015)
- Brezo J, "The genetics of suicide: a critical review of molecular studies", Psychiatr Clin North Am, 31, pp.179~203 (2008)
- Dwivedi Y, "Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects", Arch Gen Psychiatry, 60, pp.804~815 (2003)
- Karege F, "Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs", Brain Res Mol Brain Res, 136, pp.29~37 (2005)
- Egan MF, "The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function", Cell, 112, pp.257~269 (2003)
- Yamada K, "Brain-derived neurotrophic factor", TrkB signaling in memory processes, 2003, pp.91, 267~270
- Ambrus L, "Associations between avoidant focused coping strategies and polymorphisms in genes coding for brain-derived neurotrophic factor and vascular endothelial growth factor in suicide attempters: a preliminary study", Psychiatry Res, 220, pp.732~733 (2014)
- Pregelj P, "The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide", J Affect Disord, 128, pp.287~290 (2011)
- Sarchiapone M, "Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients", Neuropsychobiology, 57, pp.139~145 (2008)
- Zai CC, "The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis", Int J Neuropsychopharmacol, 15, pp.1037~1042 (2012)
- Vincze I, "Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene", Bipolar Disord, 10, pp.580~587 (2008)
- Halldorsdottir T, "Gene × environment interactions: from molecular mechanisms to behavior", Annu Rev Psychol, 68, pp.215~241 (2017)
- Belsky J, "Vulnerability genes or plasticity genes?", Mol Psychiatry, 14, pp.746~754 (2009)
- Bresin K, "Childhood emotional environment and self-injurious behaviors: the moderating role of the BDNF Val-66Met polymorphism", J Affect Disord, 150, pp.594~600 (2013)
- Zadravec Šedivy N, "Community social support as a protective factor against suicide: a gender-specific ecological study of 75 regions of 23 European countries", Health Place, 48, pp.40~46 (2017)
- Chioqueta AP, "The relationship between psychological buffers, hopelessness, and suicidal ideation: identification of protective factors", Crisis, 28, pp.67~73 (2007)
- Kleiman EM, "Utilized social support and self-esteem mediate the relationship between perceived social support and suicide ideation. A test of a multiple mediator model", Crisis, 34, pp.42~49 (2013)
- Van Orden KA, "The interpersonal theory of suicide", Psychol Rev, 117, pp.575~600 (2010)
- Sperry DM, "Child abuse and neglect, social support, and psychopathology in adulthood: a prospective investigation", Child Abuse Negl, 37, pp.415~425 (2013)
- Scarpa A, "Community violence victimization and symptoms of posttraumatic stress disorder: the moderating effects of coping and social support", J Interpers Violence, 21, pp.446~469 (2006)
- Pandey GN, "Biological basis of suicide and suicidal behavior", Bipolar Disord, 15, pp.524~541 (2013)
- Clark R, "Predicting post-traumatic stress disorder in veterans: interaction of traumatic load with COMT gene variation", J Psychiatr Res, 47, pp.1849~1856 (2013)
- Hyde LW, "Understanding risk for psychopathology through imaging gene-environment interactions", Trends Cogn Sci, 15, pp.417~427 (2011)
- Weathers FW, "The clinician-administered PTSD scale for DSM-5 (CAPS-5): development and initial psychometric evaluation in military veterans", Psychol Assess, 30, pp.383~395 (2018)
- 유재학, "한국판 아동기 외상 질문지의 타당화: 상담 및 치료적 개입에서의 활용", 한국심리학회지: 건강, 14(3), pp.563~578 (2009), 한국건강심리학회[DOI]
- Everson MD, "Concordance between adolescent reports of childhood abuse and child protective service determinations in an at-risk sample of young adolescents", Child Maltreat, 13, pp.14~26 (2008)
- Bernstein DP, "Validity of the childhood trauma questionnaire in an adolescent psychiatric population", J Am Acad Child Adolesc Psychiatry, 36, pp.340~348 (1997)
- Shin MS, "A study of suicidal ideation among high school students: the structural relation among depression, hopelessness, and suicidal ideation", Korean J Clin Psychol, 9, pp.1~19 (1990)
- Suh SY, "A study for the development of Korean version of the Duke-UNC functional social support questionnaire", J Korean Acad Fam Med, 18, pp.250~260 (1997)
- González-Castro TB, "Exploring the association between BDNF Val66Met polymorphism and suicidal behavior:meta-analysis and systematic review", J Psychiatr Res, 94, pp.208~217 (2017)
- Ratta-Apha W, "Association study of BDNF with completed suicide in the Japanese population", Psychiatry Res, 209, pp.734~736 (2013)
- Schleinitz D, "Targeted SNP genotyping using the TaqMan® assay", Methods Mol Biol, 700, pp.77~87 (2011)
- Kline RB, "Principles and practice of structural equation modeling" (2005), Guilford Press
- Hayes AF, "Regression-based statistical mediation and moderation analysis in clinical research: observations, recommendations, and implementation", Behav Res Ther, 98, pp.39~57 (2017)
- Aiken LS, "Multiple regression: testing and interpreting interactions" (1991), Sage Publications
- Zintzaras E, "Impact of Hardy-Weinberg equilibrium deviation on allele-based risk effect of genetic association studies and meta-analysis", Eur J Epidemiol, 25, pp.553~560 (2010)
- Bevilacqua L, "Interaction between FKBP5 and childhood trauma and risk of aggressive behavior", Arch Gen Psychiatry, 69, pp.62~70 (2012)
- Kempton MJ, "Metaanalysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder", Arch Gen Psychiatry, 65, pp.1017~1032 (2008)
- Perroud N, "Interaction between BDNF Val66Met and childhood trauma on adult’s violent suicide attempt", Genes Brain Behav, 7, pp.314~322 (2008)
- Schenkel LC, "The BDNF Val66Met polymorphism is an independent risk factor for high lethality in suicide attempts of depressed patients", Prog Neuropsychopharmacol Biol Psychiatry, 34, pp.940~944 (2010)
- González-Castro TB, "The role of C957T, TaqI and Ser311Cys polymorphisms of the DRD2 gene in schizophrenia: systematic review and meta-analysis", Behav Brain Funct, 12, pp.29~ (2016)
- Kang Seung-Gul, "The rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean Population", PSYCHIATRY INVESTIGATION, 17(5), pp.417~423 (2020), 대한신경정신의학회[DOI]
- Jin MJ, "Influence of childhood trauma and brain-derived neurotrophic factor Val66Met polymorphism on posttraumatic stress symptoms and cortical thickness", Sci Rep, 9, pp.6028~ (2019)
- 김신연, "대학생의 생활스트레스가 자살사고에 미치는 영향 : 지각된 사회적지지와 삶의 의미의 조절효과", 인간이해, 34(1), pp.1~13 (2013), 학생생활상담연구소
- 서인균, "학대경험이 노인의 자살생각에 미치는 영향과 스트레스, 우울, 사회적 지지의 매개효과", 보건사회연구, 31(1), pp.127~157 (2011), 한국보건사회연구원[DOI]
- 김재엽, "가정내 자녀학대경험이 청소년의 자살생각에 미치는 영향 및 사회적 지지관계의 조절효과", 한국사회복지조사연구, 21, pp.119~144 (2009), 사회복지연구소
- Runtz MG, "Social support and coping strategies as mediators of adult adjustment following childhood maltreatment", Child Abuse Negl, 21, pp.211~226 (1997)
- Valentine L, "Resilience factors associated with female survivors of childhood sexual abuse", Am J Fam Ther, 21, pp.216~224 (2007)
- Naila S, "Advances in social science, education and humanities research", pp.47~52 (2018), Atlantis Press
- Victor C, "Being alone in later life: loneliness, social isolation and living alone", Rev Clin Gerontol, 10, pp.407~417 (2000)
- Norris FH, "Received and perceived social support in times of stress: a test of the social support deterioration deterrence model", J Pers Soc Psychol, 71, pp.498~511 (1996)
- Golding JM, "Sexual assault history and social support: six general population studies", J Trauma Stress, 15, pp.187~197 (2002)
- Ullman SE, "Social support and recovery from sexual assault: a review", Aggress Violent Behav, 4, pp.343~358 (1999)
