Ghrelin Modifies the Impact of Life Stress on Suicidality in Patients With Acute Coronary Syndrome
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Objective This study investigated associations of life stressors and serum ghrelin levels with suicidal ideation (SI), and evaluated the potential mediating effect of ghrelin on associations between life stressors and SI in patients with acute coronary syndrome (ACS).Methods In total, 969 ACS patients recruited from a tertiary university hospital in Korea within 2 weeks of disease onset were evaluated in terms of life stressors (using the List of Threatening Events Questionnaire), serum ghrelin levels, and SI (using the “suicidal thoughts” item of the Montgomery–Asberg Depression Rating Scale). Covariates included sociodemographics, depression, vascular risk factors, and disease severity. After 1 year, 711 patients were re-evaluated in terms of SI; logistic regression was performed with adjustment for covariates.Results Life stressors were significantly associated with SI at baseline and follow-up. Serum ghrelin showed no such associations, but high levels thereof mediated associations of life stressors with SI; significant interaction terms were also observed after adjustment for covariates.Conclusion By evaluating life stressors and serum ghrelin levels, clinical prediction of SI in the acute and chronic phases of ACS could be improved.
Abstract
Objective This study investigated associations of life stressors and serum ghrelin levels with suicidal ideation (SI), and evaluated the potential mediating effect of ghrelin on associations between life stressors and SI in patients with acute coronary syndrome (ACS).Methods In total, 969 ACS patients recruited from a tertiary university hospital in Korea within 2 weeks of disease onset were evaluated in terms of life stressors (using the List of Threatening Events Questionnaire), serum ghrelin levels, and SI (using the “suicidal thoughts” item of the Montgomery–Asberg Depression Rating Scale). Covariates included sociodemographics, depression, vascular risk factors, and disease severity. After 1 year, 711 patients were re-evaluated in terms of SI; logistic regression was performed with adjustment for covariates.Results Life stressors were significantly associated with SI at baseline and follow-up. Serum ghrelin showed no such associations, but high levels thereof mediated associations of life stressors with SI; significant interaction terms were also observed after adjustment for covariates.Conclusion By evaluating life stressors and serum ghrelin levels, clinical prediction of SI in the acute and chronic phases of ACS could be improved.
참고문헌 (24)
- Parker G, "Acute coronary syndrome-associated depression : getting to the heart of the data", J Affect Disord, 269, pp.70~77 (2020)
- Kim JM, "Impact of suicidal ideation on long-term cardiac outcomes in patients with acute coronary syndrome : sex-specific differences", Psychother Psychosom, 87, pp.311~312 (2018)
- Kim JM, "Determinants and escitalopram treatment effects on suicidal ideation in patients with acute coronary syndrome : findings from the K-DEPACS and Es-DEPACS studies", Int J Cardiol, 219, pp.225~230 (2016)
- Pitman A, "Effects of suicide bereavement on mental health and suicide risk", Lancet Psychiatry, 1, pp.86~94 (2014)
- Feskanich D, "Stress and suicide in the nurses’ health study", J Epidemiol Community Health, 56, pp.95~98 (2002)
- Mann JJ, "Neurobiology of suicidal behaviour", Nat Rev Neurosci, 4, pp.819~828 (2003)
- Nandam LS, "Cortisol and major depressive disorder—translating findings from humans to animal models and back", Front Psychiatry, 10, pp.974~ (2019)
- Spencer SJ, "Ghrelin’s role in the hypothalamic-pituitary-adrenal axis stress response : implications for mood disorders", Biol Psychiatry, 78, pp.19~27 (2015)
- Lutter M, "The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress", Nat Neurosci, 11, pp.752~753 (2008)
- Metin Atescelik, "The Relationship between Ghrelin and Copeptin Levels, and Anxiety and Depression Levels in Suicide Attempts", Clinical Psychopharmacology and Neuroscience, 15(3), pp.256~260 (2017), 대한정신약물학회[DOI]
- Kurt E, "Evaluation of serum ghrelin and leptin levels in suicide attempters", J Psychophysiol, 22, pp.76~80 (2008)
- Wonsuk Choi, "Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders", Clinical Psychopharmacology and Neuroscience, 20(4), pp.662~674 (2022), 대한정신약물학회[DOI]
- Wonsuk Choi, "Associations of Serum Serotonin Levels with 12-week and 12-month Remission in Patients with Depressive Disorders", Clinical Psychopharmacology and Neuroscience, 20(2), pp.248~258 (2022), 대한정신약물학회[DOI]
- 김재민, "Design and Methodology for the Korean Observational and Escitalopram Treatment Studies of Depression in Acute Coronary Syndrome: K-DEPACS and EsDEPACS", PSYCHIATRY INVESTIGATION, 11(1), pp.89~94 (2014), 대한신경정신의학회
- Brugha T, "The list of threatening experiences : a subset of 12 life event categories with considerable longterm contextual threat", Psychol Med, 15, pp.189~194 (1985)
- Montgomery SA, "A new depression scale designed to be sensitive to change", Br J Psychiatry, 134, pp.382~389 (1979)
- 안용민, "한글판 Montgomery-Åsberg 우울증 평가 척도의 표준화 연구", 신경정신의학, 44(4), pp.466~476 (2005), 대한신경정신의학회
- Murrough JW, "Ketamine for rapid reduction of suicidal ideation : a randomized controlled trial", Psychol Med, 45, pp.3571~3580 (2015)
- Santos CO, "A study of suicidal thoughts in acute stroke patients", J Stroke Cerebrovasc Dis, 21, pp.749~754 (2012)
- Sheehan DV, "The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10", J Clin Psychiatry, 59(Suppl 20), pp.22~33 (1998)
- American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders" (1994), American Psychiatric Association
- Killip T 3rd, "Treatment of myocardial infarction in a coronary care unit. A two year experience with 250 patients", Am J Cardiol, 20, pp.457~464 (1967)
- Nascimento ER, "Predictors of suicidal ideation in coronary artery disease", Compr Psychiatry, 57, pp.16~20 (2015)
- Kishi Y, "Suicidal ideation among patients with acute life-threatening physical illness : patients with stroke, traumatic brain injury, myocardial infarction, and spinal cord injury", Psychosomatics, 42, pp.382~390 (2001)