A Systematic Review of Pharmacological Treatments for Internet Gaming Disorder
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective Internet gaming disorder (IGD) is an increasingly common behavioral addiction, with an estimated global prevalence of 3%. A variety of pharmacological treatments have been used to treat IGD, yet no review to date has synthesized clinical trials evaluating their efficacy. This systematic review therefore synthesized the literature reporting on clinical trials of pharmacological treatments for IGD.Methods We reviewed articles from MEDLINE, Embase, PubMed Central, CINAHL, and PsycINFO that were published as of March of 2022. A total of 828 articles were retrieved for review and 12 articles were included, reporting on a total of 724 participants.Results Most participants were male (98.6%), and all were currently living in South Korea. The most common drugs used to treat IGD were bupropion, methylphenidate, and a range of selective serotonin reuptake inhibitors. The Young Internet Addiction Scale was the most frequently used to measure gaming-related outcomes. All studies reported reduced symptoms of IGD from pre- to post-treatment. Across all clinical trials, IGD symptom reductions following the administration of pharmacological treatments ranged from 15.4% to 51.4%. A risk of bias assessment indicated that only four studies had a low risk of bias.Conclusion Preliminary results suggest that a wide array of pharmacological interventions may be efficacious in the treatment of IGD. Future studies using double-blind randomized controlled trial designs, recruiting larger and more representative samples, and controlling for psychiatric comorbidities are needed to better inform understanding of pharmacological treatments for IGD.
Abstract
Objective Internet gaming disorder (IGD) is an increasingly common behavioral addiction, with an estimated global prevalence of 3%. A variety of pharmacological treatments have been used to treat IGD, yet no review to date has synthesized clinical trials evaluating their efficacy. This systematic review therefore synthesized the literature reporting on clinical trials of pharmacological treatments for IGD.Methods We reviewed articles from MEDLINE, Embase, PubMed Central, CINAHL, and PsycINFO that were published as of March of 2022. A total of 828 articles were retrieved for review and 12 articles were included, reporting on a total of 724 participants.Results Most participants were male (98.6%), and all were currently living in South Korea. The most common drugs used to treat IGD were bupropion, methylphenidate, and a range of selective serotonin reuptake inhibitors. The Young Internet Addiction Scale was the most frequently used to measure gaming-related outcomes. All studies reported reduced symptoms of IGD from pre- to post-treatment. Across all clinical trials, IGD symptom reductions following the administration of pharmacological treatments ranged from 15.4% to 51.4%. A risk of bias assessment indicated that only four studies had a low risk of bias.Conclusion Preliminary results suggest that a wide array of pharmacological interventions may be efficacious in the treatment of IGD. Future studies using double-blind randomized controlled trial designs, recruiting larger and more representative samples, and controlling for psychiatric comorbidities are needed to better inform understanding of pharmacological treatments for IGD.
참고문헌 (55)
- "ICD-11 for Mortality and Morbidity Statistics"[URL]
- Stevens MW, "Global prevalence of gaming disorder : a systematic review and meta-analysis", Aust N Z J Psychiatry, 55, pp.553~568 (2021)
- Király O, "Problematic internet use and problematic online gaming are not the same : findings from a large nationally representative adolescent sample", Cyberpsychol Behav Soc Netw, 17, pp.749~754 (2014)
- Moreno M, "Measuring problematic internet use, internet gaming disorder, and social media addiction in young adults : cross-sectional survey study", JMIR Public Health Surveill, 8, pp.e27719~ (2022)
- Zajac K, "Treatments of internet gaming disorder : a systematic review of the evidence", Expert Rev Neurother, 20, pp.85~93 (2020)
- Stevens MWR, "Cognitive-behavioral therapy for internet gaming disorder : a systematic review and meta-analysis", Clin Psychol Psychother, 26, pp.191~203 (2019)
- Park JH, "Effectiveness of atomoxetine and methylphenidate for problematic online gaming in adolescents with attention deficit hyperactivity disorder", Hum Psychopharmacol, 31, pp.427~432 (2016)
- Song J, "Comparative study of the effects of bupropion and escitalopram on internet gaming disorder", Psychiatry Clin Neurosci, 70, pp.527~535 (2016)
- Bae S, "Bupropion shows different effects on brain functional connectivity in patients with internet-based gambling disorder and internet gaming disorder", Front Psychiatry, 9, pp.130~ (2018)
- Han DH, "Bupropion in the treatment of problematic online game play inpatients with major depressive disorder", J Psychopharmacol, 26, pp.689~696 (2012)
- Kuss DJ, "Neurobiological correlates in internet gaming disorder : a systematic literature review", Front Psychiatry, 9, pp.166~ (2018)
- Weinstein A, "Neurobiological mechanisms underlying internet gaming disorder", Dialogues Clin Neurosci, 22, pp.113~126 (2020)
- Goslar M, "Pharmacological treatments for disordered gambling : a meta-analysis", J Gambl Stud, 35, pp.415~445 (2019)
- Grant JE, "Pharmacological treatments in pathological gambling", Br J Clin Pharmacol, 77, pp.375~381 (2014)
- van den Brink W, "Evidence-based pharmacological treatment of substance use disorders and pathological gambling", Curr Drug Abuse Rev, 5, pp.3~31 (2012)
- Landis JR, "The measurement of observer agreement for categorical data", Biometrics, 33, pp.159~174 (1977)
- Sterne JA, "RoB 2 : a revised tool for assessing risk of bias in randomised trials", BMJ, 366, pp.l4898~ (2019)
- Sterne JA, "ROBINS-I : a tool for assessing risk of bias in non-randomised studies of interventions", BMJ, 355, pp.i4919~ (2016)
- Kim SM, "Combined cognitive behavioral therapy and bupropion for the treatment of problematic on-line game play in adolescents with major depressive disorder", Comp Hum Behav, 28, pp.1954~1959 (2012)
- Han DH, "The effect of methylphenidate on internet video game play in children with attention deficit", hyperactivity disorder, 2009, pp.50, 251~256
- Han DH, "Bupropion sustained release treatment decreases craving for video games and cue-induced brain activity in patients with internet video game addiction", Exp Clin Psychopharmacol, 18, pp.297~304 (2010)
- Kim YJ, "Associations between prospective symptom changes and slow-wave activity in patients with internet gaming disorder: a resting-state EEG study", Medicine(Baltimore), 96, pp.e6178~ (2017)
- Lim JA, "Changes of quality of life and cognitive function in individuals with internet gaming disorder: a 6-month follow-up", Medicine(Baltimore), 95, pp.e5695~ (2016)
- Park M, "Sustained dysfunctional information processing in patients with internet gaming disorder: 6-month follow-up ERP study", Medicine(Baltimore), 96, pp.e7995~ (2017)
- Park S, "Longitudinal changes in neural connectivity in patients with internet gaming disorder : a resting-state EEG coherence study", Front Psychiatry, 9, pp.252~ (2018)
- 남범우, "Comparing the Effects of Bupropion and Escitalopram on Excessive Internet Game Play in Patients with Major Depressive Disorder", Clinical Psychopharmacology and Neuroscience, 15(4), pp.361~368 (2017), 대한정신약물학회[DOI]
- Young KS, "Internet addiction : the emergence of a new clinical disorder", CyberPsychology Behav, 1, pp.237~244 (1998)
- Young KS, "Psychology of computer use : XL. Addictive use of the internet : a case that breaks the stereotype", Psychol Rep, 79, pp.899~902 (1996)
- "2020 essential facts about the video game industry"[URL]
- "Videogames in Europe:consumer study. European summary report November 2012"[URL]
- "Understand the consumer behaviour of Latin American gamers"[URL]
- Abijo T, "Neuropharmacological and neurogenetic correlates of opioid use disorder(OUD)as a function of ethnicity : relevance to precision addiction medicine", Curr Neuropharmacol, 18, pp.578~595 (2020)
- Avinun R, "Divergence of an association between depressive symptoms and a dopamine polygenic score in Caucasians and Asians", Eur Arch Psychiatry Clin Neurosci, 270, pp.229~235 (2020)
- González-Bueso V, "Association between internet gaming disorder or pathological video-game use and comorbid psychopathology : a comprehensive review", Int J Environ Res Public Health, 15, pp.668~ (2018)
- Cahill K, "Pharmacological interventions for smoking cessation : an overview and network meta-analysis", Cochrane Database Syst Rev, 5, pp.CD009329~ (2013)
- Thase ME, "Remission rates following antidepressant therapy with bupropion or selective serotonin reuptake inhibitors : a meta-analysis of original data from 7 randomized controlled trials", J Clin Psychiatry, 66, pp.974~981 (2005)
- Trivedi MH, "Do bupropion SR and sertraline differ in their effects on anxiety in depressed patients?", J Clin Psychiatry, 62, pp.776~781 (2001)
- Moriyama TS, "Psychopharmacology and psychotherapy for the treatment of adults with ADHD—a systematic review of available meta-analyses", CNS Spectr, 18, pp.296~306 (2013)
- Blum K, "Attention-deficit-hyperactivity disorder and reward deficiency syndrome", Neuropsychiatr Dis Treat, 4, pp.893~918 (2008)
- Belujon P, "Dopamine system dysregulation in major depressive disorders", Int J Neuropsychopharmacol, 20, pp.1036~1046 (2017)
- Oprea DC, "Behavioural addictions and the role of dopamine", Bull Integr Psychiatry, 27, pp.63~70 (2021)
- Dannon PN, "Sustained-release bupropion versus naltrexone in the treatment of pathological gambling : a preliminary blind-rater study", J Clin Psychopharmacol, 25, pp.593~596 (2005)
- Stahl SM, "A review of the neuropharmacology of bupropion, a dual norepinephrine and dopamine reuptake inhibitor", Prim Care Companion J Clin Psychiatry, 6, pp.159~166 (2004)
- Bymaster FP, "Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat : a potential mechanism for efficacy in attention deficit", hyperactivity disorder, 2002, pp.27, 699~711
- Regner MF, "Top-down network effective connectivity in abstinent substance dependent individuals", PLoS One, 11, pp.e0164818~ (2016)
- Han DH, "A failure of suppression within the default mode network in depressed adolescents with compulsive internet game play", J Affect Disord, 194, pp.57~64 (2016)
- Hong JS, "Impulsive internet game play is associated with increased functional connectivity between the default mode and salience networks in depressed patients with short allele of serotonin transporter gene", Front Psychiatry, 9, pp.125~ (2018)
- Zacharias N, "Ketamine effects on default mode network activity and vigilance : a randomized, placebo-controlled crossover simultaneous fMRI", EEG study, 2020, pp.41, 107~119
- Murphy CE 4th, "Effect of extended-release naltrexone on alcohol consumption : a systematic review and meta-analysis", Addiction, 117, pp.271~281 (2022)
- Syed YY, "Extended-release intramuscular naltrexone(VIVITROL®) : a review of its use in the prevention of relapse to opioid dependence in detoxified patients", CNS Drugs, 27, pp.851~861 (2013)
- Mouaffak F, "Naltrexone in the treatment of broadly defined behavioral addictions : a review and meta-analysis of randomized controlled trials", Eur Addict Res, 23, pp.204~210 (2017)
- Gour R, "Use of naltrexone in internet gaming disorder", Indian J Psychiatry, 64(Suppl 3), pp.S682~ (2022)
- Király O, "Ten item internet gaming disorder test(IGDT10) : measurement invariance and cross-cultural validation across seven language-based samples", Psychol Addict Behav, 33, pp.91~103 (2019)
- King DL, "Maladaptive player-game relationships in problematic gaming and gaming disorder : a systematic review", Clin Psychol Rev, 73, pp.101777~ (2019)
- Jeong-Ha Park, "Correlations among Social Anxiety, Self-Esteem, Impulsivity, and Game Genre in Patients with Problematic Online Game Playing", PSYCHIATRY INVESTIGATION, 13(3), pp.297~304 (2016), 대한신경정신의학회[DOI]