Relationship of Renal Echogenicity with Renal Pathology and Function
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Purpose: Renal ultrasonography has been widely used in children with renal disease. However, the relationship of renal echogenicity with renal pathology and function in children is not well known. Method: Ultrasound examination was performed in 75 patients undergoing renal biopsy for suspected renal disease in Konkuk University Medical Center from August 2005 to November 2015. We compared renal echogenicity to pathologic findings and renal function. Renal echogenicity was scored as 0 to 2 by comparing adjacent liver echogenicity. Three histologic characteristics were evaluated: glomerular changes, interstitial infiltration or fibrosis, and tubular atrophy. These were graded as 0 to 3, according to increasing severity. Laboratory results included urine albumin excretion and estimated glomerular filtration rate (eGFR). Results: Among pathologic findings, renal echogenicity revealed a positive correlation with interstitial infiltration or fibrosis (r=0.259, P =0.025), and with tubular atrophy (r=0.268, P=0.02). Renal echogenicity and glomerular changes were not correlated . Renal echogenicity showed a positive correlation with microalbuminuria (r=0.283, P =0.014), but a negative correlation with eGFR (r=-0.352, P =0.002). Conclusion: Increased renal echogenicity suggested severe interstitial infiltration or fibrosis and tubular atrophy among the pathologic findings. Moreover, increased echogenicity is correlated with increased urine albumin excretion and decreased eGFR. Echogenicity on ultrasonography is useful for determining the status of renal pathology and function.
Abstract
Purpose: Renal ultrasonography has been widely used in children with renal disease. However, the relationship of renal echogenicity with renal pathology and function in children is not well known. Method: Ultrasound examination was performed in 75 patients undergoing renal biopsy for suspected renal disease in Konkuk University Medical Center from August 2005 to November 2015. We compared renal echogenicity to pathologic findings and renal function. Renal echogenicity was scored as 0 to 2 by comparing adjacent liver echogenicity. Three histologic characteristics were evaluated: glomerular changes, interstitial infiltration or fibrosis, and tubular atrophy. These were graded as 0 to 3, according to increasing severity. Laboratory results included urine albumin excretion and estimated glomerular filtration rate (eGFR). Results: Among pathologic findings, renal echogenicity revealed a positive correlation with interstitial infiltration or fibrosis (r=0.259, P =0.025), and with tubular atrophy (r=0.268, P=0.02). Renal echogenicity and glomerular changes were not correlated . Renal echogenicity showed a positive correlation with microalbuminuria (r=0.283, P =0.014), but a negative correlation with eGFR (r=-0.352, P =0.002). Conclusion: Increased renal echogenicity suggested severe interstitial infiltration or fibrosis and tubular atrophy among the pathologic findings. Moreover, increased echogenicity is correlated with increased urine albumin excretion and decreased eGFR. Echogenicity on ultrasonography is useful for determining the status of renal pathology and function.
참고문헌 (18)
- Buturovic-Ponikvar J, "Ultrasonography in chronic renal failure", Eur J Radiol, 46(2), pp.115~122 (2003)
- Quaia E, "Renal parenchymal diseases: is characterization feasible with ultrasound?", Eur Radiol, 12(8), pp.2006~2020 (2002)
- Brenbridge AN, "Increased renal cortical echogenicity in pediatric renal disease: histopathologic correlations", J Clin Ultrasound, 14(8), pp.595~600 (1986)
- O'Neill WC, "Sonographic evaluation of renal failure", Am J Kidney Dis, 35(6), pp.1021~1038 (2000)
- Lucisano G, "Can renal sonography be a reliable diagnostic tool in the assessment of chronic kidney disease?", J Ultrasound Med, 34(2), pp.299~306 (2015)
- Chi T, "Increased echogenicity as a predictor of poor renal function in children with grade 3 to 4 hydronephrosis", J Urol, 175(5), pp.1898~1901 (2006)
- Rosenfield AT, "Renal parenchymal disease: histopathologic-sonographic correlation", AJR Am J Roentgenol, 137(4), pp.793~798 (1981)
- Hricak H, "Renal parenchymal disease: sonographic-histologic correlation", Radiology, 144(1), pp.141~147 (1982)
- Schwartz GJ, "New equations to estimate GFR in children with CKD", J Am Soc Nephrol, 20(3), pp.629~637 (2009)
- Ghasemi A, "Pediatric reference values for serum creatinine and estimated glomerular filtration rate in Iranians: Tehran Lipid and Glucose Study", Arch Iran Med, 18(11), pp.753~759 (2015)
- Krensky AM, "Causes of increased renal echogenicity in pediatric patients", Pediatrics, 72(6), pp.840~846 (1983)
- Han BK, "Sonographic measurements and appearance of normal kidneys in children", AJR Am J Roentgenol, 145(3), pp.611~ (1985)
- Page JE, "Ultrasound findings in renal parenchymal disease: comparison with histological appearances", Clin Radiol, 49(12), pp.867~870 (1994)
- Moghazi S, "Correlation of renal histopathology with sonographic findings", Kidney Int, 67(4), pp.1515~1520 (2005)
- Lee YS, "Is Increased Echogenicity Related to a Decrease in Glomerular Filtration Rate? Objective Measurements in Pediatric Solitary Kidney Patients--A Retrospective Analysis", PLoS One, 10(8), pp.e0133577~ (2015)
- Peerboccus M, "The impact of hydration on renal measurements and on cortical echogenicity in children", Pediatr Radiol, 43(12), pp.1557~1565 (2013)
- Manley JA, "How echogenic is echogenic? Quantitative acoustics of the renal cortex", Am J Kidney Dis, 37(4), pp.706~711 (2001)
- Vehmas T, "Factors associated with renal cortical echogenicity", Ultrasound Med Biol, 32(8), pp.1151~1155 (2006)