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만성 뇌졸중 환자의 유연성과 동맥경직도와의 관련성

Relationship between flexibility and arterial stiffness in patients with stroke.

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초록

동맥경직도(arterial stiffness)의 증가는 심혈관계 질환 및 사망과 관련이 높다. 건강한 사람에 있어 심폐체력과 동맥경직도는 역 상관관계를 가지는 것으로 보고하고 있으나 만성 뇌졸중 환자를 대상으로 유연성과 동맥경직도와의 관련성을 제시한 연구는 부족하다. 따라서 본 연구는 만성 뇌졸중 환자 94명(남 n=68, 여 n=26, 61±9세)을 대상으로 하였고, 유연성은 앉아서 윗몸 앞으로 굽히기를 측정하였으며 동맥경직도의 지표로서 경동맥-대퇴동맥 맥파전파속도를 측정하였다. 유연성과 동맥경직도간에는 유의한 역 상관관계가 나타났으며(r=-.48, p<.001), 나이, 성별, 체질량지수, 체중, 유병기간, 혈압, 심박수, 약물복용, 심폐체력을 보정한 후에도 유연성은 동맥경직도와 유의하게 관계하는 것으로 나타났다(β=-.19, p<.05). 또한 유연성이 높은 그룹은 유연성이 낮은 그룹에 비해 동맥경직도가 더 낮은 것으로 나타났다(8.9m/s vs. 11.8m/s, p<.001). 결론적으로 높은 유연성은 전통적인 심혈관계 위험인자와 심폐체력과는 독립적으로 낮은 동맥경직도와 유의한 상관이 있는 것으로 보인다.

Abstract

Increased arterial stiffness is a strong predictor of future cardiovascular events and mortality. Flexibility is associated with arterial stiffness in healthy populations, but it is unclear if this is also the case in patients with stroke. We investigate the relationship between flexibility and arterial stiffness in patients with stroke. Ninety four patients with stroke (male n=68, female n=26, 61±9 years) were recruited in the present study. We measured a modified sit and reach test on chair as an index of flexibility. Arterial stiffness was assessed by carotid-femoral pulse wave velocity using applanation tonometry. There was a significant inversely association between flexibility and pulse wave velocity (r=-.48, p<.001). In multivariable linear regression models that adjusted for age, gender, body mass index, duration of stroke, systolic blood pressure, heart rate, medication, and cardiorespiratory fitness, flexibility was an independent associated with pulse wave velocity (β=-.19, p<.05). Patients with high flexibility had significantly lower pulse wave velocity than patients with low flexibility (8.9 m/s vs. 11.8 m/s, p<.001). These findings demonstrate that high flexibility was associated with low arterial stiffness independent of risk factors and cardiorespiratory fitness in patients with stroke.

참고문헌 (44)

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