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Biomarkers Predicting Treatment-Response in Nephrotic Syndrome of Children: A Systematic Review

강희경|안요한|Jiwon M. Lee|Seon Hee Lim
대한소아신장학회 (The Korean Society Of Pediatric Nephrology)|2021.12|Childhood Kidney Diseases (Childhood Kidney diseases)|제25권 제2호|pp. 92-111

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키워드

TreatmentBiomarkerPediatricNephrotic syndromeSteroid resistant
주제분류소아과학

초록

Purpose: Nephrotic syndrome (NS) is the most common form of glomerulopathy in children. Most pediatric patients respond to glucocorticosteroid treatment (steroid- sensitive NS, SSNS), while approximately 10–15% will remain unresponsive or later become steroid-resistant. There has been a long-standing effort to find biomarkers that may predict steroid responsiveness. Methods: We systematically reviewed current studies which investigated clinically relevant biomarkers for predicting steroid responsiveness in pediatric NS. We performed a PubMed and EMBASE search to identify eligible articles. We collected data on urinary markers, blood/serum markers (including cellular phenotypes and mRNA expression), genotypes and HLA allele frequency. Results: A total of 659 articles were identified following electronic and manual searches. After reviewing the titles, abstracts, and full texts, 72 eligible articles were finally included. Vitamin D-binding protein (VDBP) seemed to be significantly elevated in SRNS than in SSNS, in both serum and urine specimen, although further validation is required. Conclusions: The present paper narratively illustrates current understandings of potential biomarkers that may help predict steroid responsiveness. Further investigation and collaboration involving a larger number of patients are necessary.

Abstract

Purpose: Nephrotic syndrome (NS) is the most common form of glomerulopathy in children. Most pediatric patients respond to glucocorticosteroid treatment (steroid- sensitive NS, SSNS), while approximately 10–15% will remain unresponsive or later become steroid-resistant. There has been a long-standing effort to find biomarkers that may predict steroid responsiveness. Methods: We systematically reviewed current studies which investigated clinically relevant biomarkers for predicting steroid responsiveness in pediatric NS. We performed a PubMed and EMBASE search to identify eligible articles. We collected data on urinary markers, blood/serum markers (including cellular phenotypes and mRNA expression), genotypes and HLA allele frequency. Results: A total of 659 articles were identified following electronic and manual searches. After reviewing the titles, abstracts, and full texts, 72 eligible articles were finally included. Vitamin D-binding protein (VDBP) seemed to be significantly elevated in SRNS than in SSNS, in both serum and urine specimen, although further validation is required. Conclusions: The present paper narratively illustrates current understandings of potential biomarkers that may help predict steroid responsiveness. Further investigation and collaboration involving a larger number of patients are necessary.

참고문헌 (144)

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관련 논문AI추천

Immunopathogenesis of childhood idiopathic nephrotic syndrome정해일대한소아신장학회 · Childhood Kidney Diseases2023 · 제27권 제1호Steroid-sensitive nephrotic syndrome in children: Korean Society of Pediatric Nephrology clinical practice recommendationsCho Heeyeon, Cho Min Hyun, Cho Myung Hyun, Kang Hee Gyung, Kim Jeong Yeon, Lee Hyun Kyung, Lee Joo Hoon, Lee Yeon hee, Park Dong Ah, Park Eujin, Suh Jin-Soon대한소아신장학회 · Childhood Kidney Diseases2025 · 제29권 제3호Pathogenesis of Minimal Change Nephrotic Syndrome: A Review of the Underlying Molecular Mechanisms양은미대한소아신장학회 · Childhood Kidney Diseases2019 · 제23권 제1호Clinical Features and Long-Term outcomes of Patients with Late Steroid Resistant/Sensitive Nephrotic Syndrome: A Single Center StudyHye Ryun Yeh, Joo Hoon Lee, Young Seo Park대한소아신장학회 · Childhood Kidney Diseases2015 · 제19권 제2호Antibody Status in Children with Steroid-Sensitive Nephrotic Syndrome고대균, 이경일, 이준성, 한지환, 황자영연세대학교의과대학 · Yonsei Medical Journal2010 · 제51권 제2호Circulating Permeability Factors in Idiopathic Nephrotic SyndromeTae Sun Ha대한소아신장학회 · Childhood Kidney Diseases2019 · 제23권 제1호

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