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운동선수의 비타민D에 대한 최신지견

Recent Advance on Vitamin D in Athletes

박수현|송홍선|조진경
한국운동생리학회|2021.08|운동과학 (Exercise Science)|제30권 제3호|pp. 278-287

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키워드

Vitamin D운동수행능력근력Muscle strengthAthletic performance비타민D비타민D 보조제Vitamin D supplement

초록

PURPOSE: Vitamin D plays important roles in calcium homeostasis and bone metabolism. Since vitamin D receptors (VDRs) are located in a variety of organs, including skeletal muscle, vitamin D has potentially widespread effects. The purpose of this review was to summarize the current understanding of the effects of vitamin D on muscle function and exercise performance in athletes. METHODS: In this narrative review, we summarized previous studies by searching the literature in the PubMed, Google Scholar, and Science Direct databases. RESULTS: Vitamin D has been shown to regulate multiple actions in skeletal muscle tissue, such as myocyte proliferation and growth via genomic and non-genomic molecular pathways. Higher levels of vitamin D are associated with improved skeletal muscle function and exercise performance. Moreover, in some studies, vitamin D supplementation has beneficial effects on muscle strength in athletes, especially those who are vitamin D-deficient. CONCLUSIONS: Vitamin D appears to have beneficial effects on muscle and exercise performance in athletes. However, more studies are needed to clarify the action and dosage of vitamin D in athletes.

Abstract

PURPOSE: Vitamin D plays important roles in calcium homeostasis and bone metabolism. Since vitamin D receptors (VDRs) are located in a variety of organs, including skeletal muscle, vitamin D has potentially widespread effects. The purpose of this review was to summarize the current understanding of the effects of vitamin D on muscle function and exercise performance in athletes. METHODS: In this narrative review, we summarized previous studies by searching the literature in the PubMed, Google Scholar, and Science Direct databases. RESULTS: Vitamin D has been shown to regulate multiple actions in skeletal muscle tissue, such as myocyte proliferation and growth via genomic and non-genomic molecular pathways. Higher levels of vitamin D are associated with improved skeletal muscle function and exercise performance. Moreover, in some studies, vitamin D supplementation has beneficial effects on muscle strength in athletes, especially those who are vitamin D-deficient. CONCLUSIONS: Vitamin D appears to have beneficial effects on muscle and exercise performance in athletes. However, more studies are needed to clarify the action and dosage of vitamin D in athletes.

참고문헌 (62)

  1. Holick MF, "High prevalence of vitamin D inadequacy and implications for health", Mayo Clin Proc, 81(3), pp.353~373 (2006)[DOI]
  2. 추지민, "한국 성인에서 신체활동 및 좌식시간과 혈중 비타민 D와의 연관성: 2014년 국민건강영양조사 결과를 바탕으로", Korean Journal of Family Practice, 10(2), pp.123~128 (2020), 대한가정의학회[DOI]
  3. Zhang R, "Vitamin D in health and disease: current perspectives", Nutr J, 9, pp.65~ (2010)[DOI]
  4. Owens DJ, "Vitamin D and the athlete: current perspectives and new challenges", Sports Med, 48(Suppl 1), pp.3~16 (2018)[DOI]
  5. Holick MF, "Vitamin D : importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis", Am J Clin Nutr, 79(3), pp.362~371 (2004)
  6. 양성석, "국내 운동선수에서 비타민 D 수치의 현 상태 및 결핍과 관련된 인자: 실내외 종목에 따른 차이, 나이, 성별, 체질량지수, 계절 변동과의 관련성", 대한스포츠의학회지, 36(2), pp.71~76 (2018), 대한스포츠의학회[DOI]
  7. Jäpelt RB, "Vitamin D in plants : a review of occurrence, analysis, and biosynthesis", Front Plant Sci, 4, pp.136~ (2013)
  8. Zhang RH, "Analysis of vitamin D status in men highly exposed to sunlight", biomed environ sci, 28(12), pp.913~916 (2015)[DOI]
  9. Remelli F, "Vitamin D deficiency and sarcopenia in older persons", Nutrients, 11(12) (2019)[DOI]
  10. Hollis BW, "Circulating vitamin D3 and 25-hydroxyvitamin D in humans: an important tool to define adequate nutritional vitamin D status", J Steroid Biochem Mol Biol, 103(3-5), pp.631~634 (2007)[DOI]
  11. Holick MF, "Evaluation, treatment, and prevention of vitamin D deficiency : an endocrine society clinical practice guideline", J Clin Endocrinol Metab, 96(7), pp.1911~1930 (2011)[DOI]
  12. Araki T, "Vitamin D intoxication with severe hypercalcemia due to manufacturing and labeling errors of two dietary supplements made in the united states", J Clin Endocrinol Metab, 96(12), pp.3603~3608 (2011)[DOI]
  13. Slatopolsky E, "Calcium, phosphorus and vitamin D disorders in uremia", Contrib Nephrol, 149, pp.261~271 (2005)[DOI]
  14. Ceglia L, "Vitamin D and its role in skeletal muscle", Calcif Tissue Int, 92(2), pp.151~162 (2013)[DOI]
  15. Girgis CM, "The roles of vitamin D in skeletal muscle : form, function, and metabolism", Endocr Rev, 34(1), pp.33~83 (2013)[DOI]
  16. Demay MB, "Mechanism of vitamin D receptor action", Ann N Y Acad Sci, 1068(1), pp.204~213 (2006)
  17. Pojednic RM, "The emerging biomolecular role of vitamin D in skeletal muscle", Exerc Sport Sci Rev, 42(2), pp.76~81 (2014)[DOI]
  18. Halfon M, "Vitamin D : a review on its effects on muscle strength, the risk of fall, and frailty", Biomed Res Int, 2015, pp.953241~ (2015)[DOI]
  19. Buitrago C, "Role of VDR in 1alpha, 25-dihydroxyvitamin D3-dependent non-genomic activation of MAPKs, Src and akt in skeletal muscle cells", J Steroid Biochem Mol Biol, 136, pp.125~130 (2013)[DOI]
  20. Braga M, "Vitamin D induces myogenic differentiation in skeletal muscle derived stem cells", Endocr Connect, 6(3), pp.139~150 (2017)[DOI]
  21. Girgis CM, "Vitamin D receptor ablation and vitamin D deficiency result in reduced grip strength, altered muscle fibers, and increased myostatin in mice", Calcif Tissue Int, 97(6), pp.602~610 (2015)[DOI]
  22. Endo I, "Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors", Endocrinology, 144(12), pp.5138~5144 (2003)[DOI]
  23. Tanaka M, "Vitamin D receptor gene silencing effects on differentiation of myogenic cell lines", Muscle Nerve, 49(5), pp.700~708 (2014)[DOI]
  24. Srikuea R, "VDR and CYP27B1are expressed in C2C12 cells and regenerating skeletal muscle : potential role in suppression of myoblast proliferation", Am J Physiol Cell Physiol, 303(4), pp.C396~C405 (2012)[DOI]
  25. Makanae Y, "Acute bout of resistance exercise increases vitamin D receptor protein expression in rat skeletal muscle", Exp Physiol, 100(10), pp.1168~1176 (2015)[DOI]
  26. Salles J, "1, 25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt", PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes, 2013, pp.57(12), 2137~2146
  27. Yoshikawa S, "Osteomalacic myopathy", Endocrinol Jpn, 26(Suppl), pp.65~72 (1979)[DOI]
  28. Oh JH, "The level of vitamin D in the serum correlates with fatty degeneration of the muscles of the rotator cuff", J Bone Joint Surg Br, 91(12), pp.1587~1593 (2009)[DOI]
  29. Reddy Vanga S, "Role of vitamin D in cardiovascular health", Am J Cardiol, 106(6), pp.798~805 (2010)[DOI]
  30. Norman PE, "Vitamin D and cardiovascular disease", Circ Res, 114(2), pp.379~393 (2014)[DOI]
  31. Sinha A, "Improving the vitamin D status of vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle", J Clin Endocrinol Metab, 98(3), pp.E509~E513 (2013)[DOI]
  32. Choi HS, "Vitamin D insufficiency in korea--a greater threat to younger generation : the korea national health and nutrition examination survey(KNHANES)2008", J Clin Endocrinol Metab, 96(3), pp.643~651 (2011)[DOI]
  33. Yang J, "Low serum vitamin D levels increase the mortality of cardiovascular disease in older adults : a dose-response meta-analysis of prospective studies", Medicine(Baltimore), 98(34), pp.e16733~ (2019)[DOI]
  34. Hildebrand RA, "Compromised vitamin D status negatively affects muscular strength and power of collegiate athletes", Int J Sport Nutr Exerc Metab, 26(6), pp.558~564 (2016)[DOI]
  35. Koundourakis NE, "Vitamin D and exercise performance in professional soccer players", PLoS One, 9(7), pp.e101659~ (2014)[DOI]
  36. Wilson-Barnes SL, "Seasonal variation in vitamin D status, bone health and athletic performance in competitive university student athletes : a longitudinal study", J Nutr Sci, 9, pp.e8~ (2020)[DOI]
  37. Wilson-Barnes SL, "The relationship between vitamin D status, intake and exercise performance in UK University-level athletes and healthy inactive controls", PLoS One, 16(4), pp.e0249671~ (2021)[DOI]
  38. Ksiazek A, "Relationship between 25(OH)D levels and athletic performance in elite Polish judoists", Biol Sport, 35(2), pp.191~196 (2018)[DOI]
  39. de Rezende A, II, "The relationship between vitamin D Levels, injury and muscle function in adolescent dancers", Int J Sports Med, 41(6), pp.360~364 (2020)[DOI]
  40. Bischoff-Ferrari HA, "Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged>or =60 y", Am J Clin Nutr, 80(3), pp.752~758 (2004)[DOI]
  41. Dhesi JK, "Vitamin D supplementation improves neuromuscular function in older people who fall", Age Ageing, 33(6), pp.589~595 (2004)[DOI]
  42. Inbar O, "Relationships between leg muscle fiber type distribution and leg exercise performance", Int J Sports Med, 2(3), pp.154~159 (1981)[DOI]
  43. Pereira R, "Muscle activation sequence compromises vertical jump performance", Serb J Sports Sci, 2, pp.85~90 (2008)
  44. Hamilton B, "Vitamin D concentration in 342 professional football players and association with lower limb isokinetic function", J Sci Med Sport, 17(1), pp.139~143 (2014)[DOI]
  45. Dubnov-Raz G, "Vitamin D concentrations and physical performance in competitive adolescent swimmers", Pediatr Exerc Sci, 26(1), pp.64~70 (2014)[DOI]
  46. Kim DK, "The relationship between vitamin D status and rotator cuff muscle strength in professional volleyball athletes", nutrients, 11(11) (2019)[DOI]
  47. Kim DK, "Association of vitamin D status with lower limb muscle strength in professional basketball players: a cross-sectional study", Nutrients, 12(9) (2020)[DOI]
  48. Ksiazek A, "25(OH)D3 Levels relative to muscle strength and maximum oxygen uptake in athletes", J Hum Kinet, 50, pp.71~77 (2016)[DOI]
  49. Maroon JC, "Vitamin D profile in national football league players", Am J Sports Med, 43(5), pp.1241~1245 (2015)[DOI]
  50. Wang P, "Association between polymorphisms of vitamin D receptor gene apaI, bsmI and taqI and muscular strength in young chinese women", Int J Sports Med, 27(3), pp.182~186 (2006)[DOI]
  51. Bahat G, "BsmI polymorphism in the vitamin D receptor gene is associated with leg extensor muscle strength in elderly men", Aging Clin Exp Res, 22(3), pp.198~205 (2010)[DOI]
  52. Ceglia L, "A randomized study on the effect of vitamin D(3)supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women", J Clin Endocrinol Metab, 98(12), pp.E1927~E1935 (2013)[DOI]
  53. Dawson-Hughes B, "Vitamin D and muscle function", J Steroid Biochem Mol Biol, 173, pp.313~316 (2017)[DOI]
  54. Wyon MA, "The influence of winter vitamin D supplementation on muscle function and injury occurrence in elite ballet dancers : a controlled study", J Sci Med Sport, 17(1), pp.8~12 (2014)[DOI]
  55. Wyon MA, "Acute effects of vitamin D3 supplementation on muscle strength in judoka athletes : a randomized placebo-controlled, double-blind trial", Clin J Sport Med, 26(4), pp.279~284 (2016)[DOI]
  56. Jung HC, "Correcting vitamin D insufficiency improves some but not all aspects of physical performance during winter training in taekwondo athletes", Int J Sport Nutr Exerc Metab, 28(6), pp.635~643 (2018)[DOI]
  57. Close GL, "Assessment of vitamin D concentration in non-supplemented professional athletes and healthy adults during the winter months in the UK : implications for skeletal muscle function", J Sports Sci, 31(4), pp.344~353 (2013)[DOI]
  58. D concentration and physical performance : a randomised dose-response study, "Br J Sports Med", 2013, 692~696, 10.1136[DOI]
  59. Dubnov-Raz G, "Vitamin D supplementation and physical performance in adolescent swimmers", Int J Sport Nutr Exerc Metab, 25(4), pp.317~325 (2015)[DOI]
  60. Nieman DC, "Vitamin D2 supplementation amplifies eccentric exercise-induced muscle damage in NASCAR pit crew athletes", Nutrients, 6(1), pp.63~75 (2013)[DOI]
  61. Logan VF, "Longterm vitamin D3 supplementation is more effective than vitamin D2in maintaining serum 25-hydroxyvitamin D status over the winter months", Br J Nutr, 109(6), pp.1082~1088 (2013)[DOI]
  62. Armas LA, "Vitamin D2 is much less effective than vitamin D3 in humans", J Clin Endocrinol Metab, 89(11), pp.5387~5391 (2004)[DOI]

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