PGC-1α유전자 다형성과 신체활동 수준에 따른 대학생의 신체구성, 혈압, 심폐체력의 비교
Comparisons of body composition, blood pressure, and cardiorespiratory fitness according to PGC-1a gene polymorphisms and physical activity levels in college students.
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본 연구의 목적은 국내 20대 건강한 남녀 대학생을 대상으로 PGC-1α 유전자 다형(유전적) 및 PGC-1α 유전자 다형과 신체활동 수준(상중하)(유전적＋환경적)에 따른 신체구성, 혈압 및 심폐체력의 차이를 검증하는데 있다. 연구의 대상자는 20대의 건강한 남녀 대학생 총 1286명을 대상으로 신체구성(신장, 체중, BMI, BF%, muscle, waist, WHR), 혈압 및 심폐체력을 측정하였고, Real-Time PCR을 이용하여 PGC-1a Gly482Ser을 분석하였다. 총 1286명을 대상으로 관찰된 PGC-1α 유전자다형의 빈도를 이용한 Hardy-Weinberg 평형성을 검정한 결과, 관찰된 PGC-1α 유전자 형질의 빈도는 기대(예측)빈도와 유의한 차이를 나타내지 않았다. 한국 20대 건강한 남녀 대학생을 대상으로 PGC-1α Gly482Ser 유전자 다형에 따른 신체구성, 혈압 및 심폐체력은 차이가 없었다. 또한 PGC-1α Gly482Ser 유전자 다형과 신체활동 수준(상중하)에 따른 신체구성과 혈압은 차이가 없었다. 하지만 중간 수준의 신체활동을 하는 집단에서 PGC-1α Gly482Ser 유전자 다형에 따른 심폐체력은 차이가 있었다. 결론적으로, 한국의 건강한 대학생의 PGC-1α Gly482Ser 유전자 다형은 신체구성, 혈압 그리고 심폐체력의 차이를 결정짓는 유전자가 아닌 것으로 판단되며, PGC-1α Gly482Ser 유전자 다형과 신체활동 수준은 신체 구성과 혈압의 차이를 결정짓는 유전적 환경적 요인이 아닌 것으로 판단된다.
Abstract
The purpose of this study was to investigate whether or not the PGC-1a gene polymorphisms and physical activity levels was associated with body composition, blood pressure and cardiorespiratory fitness(CRF) in korean college students. The PGC-1a gene were genotype in 1286 Korean college students by using the Real-Time Quantitative PCR with TaqMan detection chemistry, CRF was measured as the maximum volume of minute oxygen consumption during a graded treadmill testing, Body composition(height, weight, body mass index, percent body fat, waist, WHR) and blood pressure were measured using our standardized protocols. Chi-square analysis was used to test the Hardy-Weinberg equilibrium based on the genotype frequencies of the PGC-1a gene polymorphism in the study population, and its relative frequency were in the Hardy-Weinberg equilibrium. Therefore, it was confirmed that a sample size(n=1286) of the current study represented the total population appropriately in terms of the PGC-1a genotype distribution. On the other hand, body composition, blood pressure and CRF was not significantly different across the PGC-1a genotypes. Also, body composition and blood pressure was not significantly different across the PGC-1a genotypes and physical activity levels. but CRF was significantly different across the PGC-1a genotypes and middle level of physical activity. In conclusion, the current findings suggest that the PGC-1a genotype is not associated with the body composition, blood pressure and CRF in the korean college students. Also, PGC-1a genotype and physical activity levels is not associated with the body composition, blood pressure in the korean college students.
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