Role of the gut–brain axis in energy and glucose metabolism

참고문헌 (311)

1. Hales, C. M., "Prevalence of obesity and severe obesity among adults: United States, 2017–2018", NCHS Data Brief, pp.1~8 (2020)
2. Saeedi, P., "Global and regional diabetes prevalence estimates for 2019and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas", Diabetes Res. Clin. Pract, 157, pp.107843~ (2019)
3. Leung, M. Y. M., "The burden of obesity on diabetes in the United States: medical expenditure panel survey, 2008 to 2012", Value Health, 20, pp.77~84 (2017)
4. Sjöström, L., "Bariatric surgery and reduction in morbidity and mortality : experiences from the SOS study", Int. J. Obes, 32, pp.S93~S97 (2008)
5. Reid, T., "Choosing GLP-1 receptor agonists or DPP-4 inhibitors : weighing the clinical trial evidence", Clin. Diabetes, 30, pp.3~ (2012)
6. Wu, H., "Metformin alters the gut microbiome of individuals with treatmentnaive type 2 diabetes, contributing to the therapeutic effects of the drug", Nat. Med, 23, pp.850~858 (2017)
7. Duca, F. A., "Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats", Nat. Med, 21, pp.506~511 (2015)
8. Sun, L., "Gut microbiota and intestinal FXR mediate the clinical benefits of metformin", Nat. Med, 24, pp.1919~1929 (2018)
9. Mithieux, G., "Gut Microbiota and host metabolism : what relationship", Neuroendocrinology, 106, pp.352~356 (2018)
10. Ilhan, Z. E., "Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery", NPJ Biofilms Microbiomes, 6, pp.12~ (2020)
11. Iggo, A., "Tension receptors in the stomach and the urinary bladder", J. Physiol, 128, pp.593~607 (1955)
12. Lal, S., "Vagal afferent responses to fatty acids of different chain length in the rat", Am. J. Physiol. Gastrointest. Liver Physiol, 281, pp.G907~G915 (2001)
13. de Lartigue, G., "Novel developments in vagal afferent nutrient sensing and its role in energy homeostasis", Curr. Opin. Pharmacol, 31, pp.38~43 (2016)
14. Schwartz, M. W., "Central nervous system control of food intake", Nature, 404, pp.661~671 (2000)
15. Lam, C. K. L., "CNS regulation of glucose homeostasis", Physiol. (Bethesda), 24, pp.159~170 (2009)
16. Gribble, F. M., "Enteroendocrine cells: chemosensors in the intestinal epithelium", Annu. Rev. Physiol, 78, pp.277~299 (2016)
17. Gribble, F. M., "Function and mechanisms of enteroendocrine cells and gut hormones in metabolism", Nat. Rev. Endocrinol, 15, pp.226~237 (2019)
18. Turnbaugh, P. J., "The human microbiome project", Nature, 449, pp.804~810 (2007)
19. Bauer, P. V., "Regulation of energy balance by a gut–brain axis and involvement of the gut microbiota", Cell. Mol. Life Sci, 73, pp.737~755 (2016)
20. Tsigos, C., "Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress", J. Psychosom. Res, 53, pp.865~871 (2002)
21. Berthoud, H.-R., "The vagus nerve, food intake and obesity", Regul. Pept, 149, pp.15~25 (2008)
22. Goldstein, N., "Hypothalamic detection of macronutrients via multiple gutbrain pathways", Cell Metab, 33, pp.676~687.e5 (2021)
23. Brown, T. A. L., "The feeding responses evoked by cholecystokinin are mediated by vagus and splanchnic nerves", Peptides, 32, pp.1581~1586 (2011)
24. Sclafani, A., "Selective effects of vagal deafferentation and celiac-superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients", Physiol. Behav, 78, pp.285~294 (2003)
25. Furness, J. B., "The enteric nervous system and neurogastroenterology", Nat. Rev. Gastroenterol. Hepatol, 9, pp.286~294 (2012)
26. Berthoud, H. R., "Anatomical relationship between vagal afferent fibers and CCK-immunoreactive entero-endocrine cells in the rat small intestinal mucosa", Acta Anat, 156, pp.123~131 (1996)
27. Berthoud, H. R., "Vagal sensors in the rat duodenal mucosa : distribution and structure as revealed by in vivo DiItracing", Anat. Embryol, 191, pp.203~212 (1995)
28. Bai, L., "Genetic identification of vagal sensory neurons that control feeding", Cell, 179, pp.1129~1143.e23 (2019)
29. Berthoud, H. R., "Distribution and structure of vagal afferent intraganglionic laminar endings(IGLEs)in the rat gastrointestinal tract", Anat. Embryol, 195, pp.183~191 (1997)
30. Blackshaw, L. A., "Effects of cholecystokinin(CCK-8)on two classes of gastroduodenal vagal afferent fibre", J. Auton. Nerv. Syst, 31, pp.191~201 (1990)
31. Kupari, J., "An atlas of vagal sensory neurons and their molecular specialization", Cell Rep, 27, pp.2508~2523.e4 (2019)
32. Williams, E. K., "Sensory neurons that detect stretch and nutrients in the digestive system", Cell, 166, pp.209~221 (2016)
33. Fan, W., "Role of melanocortinergic neurons in feeding and the agouti obesity syndrome", Nature, 385, pp.165~168 (1997)
34. Cowley, M. A., "Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus", Nature, 411, pp.480~484 (2001)
35. Sohn, J. -W., "Neuronal circuits that regulate feeding behavior and metabolism", Trends Neurosci, 36, pp.504~512 (2013)
36. Berthoud, H. -R., "Functional and chemical anatomy of the afferent vagal system", Auton. Neurosci, 85, pp.1~17 (2000)
37. Han, W., "A neural circuit for gut-induced reward", Cell, 175, pp.665~678.e23 (2018)
38. Mei, N., "Vagal glucoreceptors in the small intestine of the cat", J. Physiol, 282, pp.485~506 (1978)
39. Schwartz, G. J., "Duodenal nutrient exposure elicits nutrientspecific gut motility and vagal afferent signals in rat", Am. J. Physiol, 274, pp.R1236~R1242 (1998)
40. Randich, A., "Responses of celiac and cervical vagal afferents to infusions of lipids in the jejunum or ileum of the rat", Am. J. Physiol. Regul. Integr. Comp. Physiol, 278, pp.R34~R43 (2000)
41. Emond, M., "Meal-related stimuli differentially induce c-Fos activation in the nucleus of the solitary tract", Am. J. Physiol. Regul. Integr. Comp. Physiol, 280, pp.R1315~R1321 (2001)
42. Lorenz, D. N., "Vagal mediation of the cholecystokinin satiety effect in rats", Physiol. Behav, 29, pp.599~604 (1982)
43. Yox, D. P., "Capsaicin attenuates suppression of sham feeding induced by intestinal nutrients", Am. J. Physiol. Regul. Integr. Comp. Physiol, 255, pp.R569~R574 (1988)
44. Mönnikes, H., "Pathways of Fos expression in locus ceruleus, dorsal vagal complex, and PVN in response to intestinal lipid", Am. J. Physiol. Regul. Integr. Comp. Physiol, 273, pp.R2059~R2071 (1997)
45. Yao, G., "Effective weight control via an implanted self-powered vagus nerve stimulation device", Nat. Commun, 9, pp.5349~ (2018)
46. Bugajski, A. J., "Effect of long-term vagal stimulation on food intake and body weight during diet induced obesity in rats", J. Physiol. Pharmacol, 58(Suppl 1), pp.5~12 (2007)
47. Krolczyk, G., "Effects of continuous microchip(MC)vagal neuromodulation on gastrointestinal function in rats", J. Physiol. Pharmacol, 52, pp.705~715 (2001)
48. Burneo, J. G., "Weight loss associated with vagus nerve stimulation", Neurology, 59, pp.463~ (2002)
49. Wang, P. Y. T., "Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production", Nature, 452, pp.1012~1016 (2008)
50. Fujita, S., "Celiac-superior mesenteric ganglionectomy, but not vagotomy, suppresses the sympathoadrenal response to insulin-induced hypoglycemia", Diabetes, 54, pp.3258~3264 (2005)
51. Mithieux, G., "Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein", Cell Metab, 2, pp.321~329 (2005)
52. Adachi, A., "Convergence of hepatoportal glucose-sensitive afferent signals to glucose-sensitive units within the nucleus of the solitary tract", Neurosci. Lett, 46, pp.215~218 (1984)
53. Shimizu, N., "Functional correlations between lateral hypothalamic glucose-sensitive neurons and hepatic portal glucose-sensitive units in rat", Brain Res, 265, pp.49~54 (1983)
54. Langhans, W., "Intrameal hepatic-portal infusion of glucose reduces spontaneous meal size in rats", Physiol. Behav, 73, pp.499~507 (2001)
55. Tordoff, M. G., "Hepatic portal glucose infusions decrease food intake and increase food preference", Am. J. Physiol, 251, pp.R192~R196 (1986)
56. Burcelin, R., "Portal glucose infusion in the mouse induces hypoglycemia : evidence that the hepatoportal glucose sensor stimulates glucose utilization", Diabetes, 49, pp.1635~1642 (2000)
57. Pal, A., "Effect of portal glucose sensing on systemic glucose levels in SD and ZDF rats", PLoS ONE, 11, pp.e0165592~ (2016)
58. Soty, M., "Gut-brain glucose signaling in energy homeostasis", Cell Metab, 25, pp.1231~1242 (2017)
59. De Vadder, F., "Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis", Neurogastroenterol. Motil, 27, pp.443~448 (2015)
60. Balkan, B., "Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms", Am. J. Physiol. Regul. Integr. Comp. Physiol, 279, pp.R1449~R1454 (2000)
61. Burcelin, R., "Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor", Diabetes, 50, pp.1720~ (2001)
62. Vahl, T. P., "Glucagon-like peptide-1(GLP-1)receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats", Endocrinology, 148, pp.4965~4973 (2007)
63. Daly, D. M., "Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse", J. Physiol, 589, pp.2857~2870 (2011)
64. Donovan, M. J., "Activation of hindbrain neurons in response to gastrointestinal lipid is attenuated by high fat, high energy diets in mice prone to diet-induced obesity", Brain Res, 1248, pp.136~140 (2009)
65. Duca, F. A., "Reduced CCK signaling in obese-prone rats fed a high fat diet", Horm. Behav, 64, pp.812~817 (2013)
66. Swartz, T. D., "Differential feeding behavior and neuronal responses to CCK in obesity-prone and -resistant rats", Brain Res, 1308, pp.79~86 (2010)
67. Grabauskas, G., "High-fat diet-induced vagal afferent dysfunction via upregulation of 2-pore domain potassium TRESK channel", JCI Insight, 4, pp.e130402~ (2019)
68. de Lartigue, G., "Role of the vagus nerve in the development and treatment of diet-induced obesity", J. Physiol, 594, pp.5791~5815 (2016)
69. Kugler, E. M., "Mechanical stress activates neurites and somata of myenteric neurons", Front. Cell. Neurosci, 9, pp.342~342 (2015)
70. Mao, Y., "Characterization of myenteric sensory neurons in the mouse small intestine", J. Neurophysiol, 96, pp.998~1010 (2006)
71. Vincent, K. M., "Intestinal glucose-induced calciumcalmodulin kinase signaling in the gut-brain axis in awake rats", Neurogastroenterol. Motil, 23, pp.e282~e293 (2011)
72. Grasset, E., "A specific gut microbiota dysbiosis of type 2 diabetic mice induces GLP-1 resistance through an enteric NO-dependent and gut-brain axis mechanism", Cell Metab, 25, pp.1075~1090.e5 (2017)
73. Richards, P., "Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model", Diabetes, 63, pp.1224~ (2014)
74. Yano, J. M., "Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis", Cell, 161, pp.264~276 (2015)
75. Liu, M. -T., "Glutamatergic enteric neurons", J. Neurosci, 17, pp.4764~ (1997)
76. Kondoh, T., "Activation of the gut-brain axis by dietary glutamate and physiologic significance in energy homeostasis", Am. J. Clin. Nutr, 90, pp.832S~837S (2009)
77. Niijima, A., "Reflex effects of oral, gastrointestinal and hepatoportal glutamate sensors on vagal nerve activity", J. Nutr, 130, pp.971S~973S (2000)
78. Ritter, R. C., "A tale of two endings: modulation of satiation by NMDA receptors on or near central and peripheral vagal afferent terminals", Physiol. Behav, 105, pp.94~99 (2011)
79. Fournel, A., "Apelin targets gut contraction to control glucose metabolism via the brain", Gut, 66, pp.258~269 (2017)
80. Abot, A., "Galanin enhances systemic glucose metabolism through enteric Nitric Oxide Synthase-expressed neurons", Mol. Metab, 10, pp.100~108 (2018)
81. Engelstoft, M. S., "Enteroendocrine cell types revisited", Curr. Opin. Pharmacol, 13, pp.912~921 (2013)
82. Eissele, R., "Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man", Eur. J. Clin. Invest, 22, pp.283~291 (1992)
83. Furness, J. B., "The gut as a sensory organ", Nat. Rev. Gastroenterol. Hepatol, 10, pp.729~740 (2013)
84. Glass, L. L., "Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine", Mol. Metab, 6, pp.1296~1303 (2017)
85. Gehart, H., "Identification of enteroendocrine regulators by real-time singlecell differentiation mapping", Cell, 176, pp.1158~1173.e16 (2019)
86. Beumer, J., "Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient", Nat. Cell Biol, 20, pp.909~916 (2018)
87. Egerod, K. L., "A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin", Endocrinology, 153, pp.5782~5795 (2012)
88. Moor, A. E., "Spatial reconstruction of single enterocytes uncovers broad zonation along the intestinal villus axis", Cell, 175, pp.1156~1167.e15 (2018)
89. Roberts, G. P., "Comparison of human and murine enteroendocrine cells by transcriptomic and peptidomic profiling", Diabetes, 68, pp.1062~1072 (2019)
90. Grün, D., "Single-cell messenger RNA sequencing reveals rare intestinal cell types", Nature, 525, pp.251~255 (2015)
91. Habib, A. M., "Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry", Endocrinology, 153, pp.3054~3065 (2012)
92. Page, A. J., "Vagal afferent dysfunction in obesity : cause or effect", J. Physiol, 594, pp.5~6 (2016)
93. Christiansen, C. B., "The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon", Am. J. Physiol. Gastrointest. Liver Physiol, 315, pp.G53~G65 (2018)
94. Kuhre, R. E., "Mechanisms underlying gut hormone secretion using the isolated perfused rat small intestine", JoVE, 26, pp.e58533~ (2019)
95. Bohórquez, D. V., "Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells", J. Clin. Invest, 125, pp.782~786 (2015)
96. Kaelberer, M. M., "A gut-brain neural circuit for nutrient sensory transduction", Science, 361, pp.eaat5236~ (2018)[DOI]
97. Nauck, M. A., "Incretin hormones : Their role in health and disease", Diabetes Obes. Metab, 20, pp.5~21 (2018)
98. Drucker, D. J., "The biology of incretin hormones", Cell Metab, 3, pp.153~165 (2006)
99. Rocca, A. S., "Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion", Endocrinology, 140, pp.1687~1694 (1999)
100. Vilsbøll, T., "Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients", Diabetes, 50, pp.609~613 (2001)
101. Parker, H. E., "Molecular mechanisms underlying nutrient-stimulated incretin secretion", Expert Rev. Mol. Med, 12, pp.e1~ (2010)
102. Ezcurra, M., "Molecular mechanisms of incretin hormone secretion", Curr. Opin. Pharmacol, 13, pp.922~927 (2013)
103. Gribble, F. M., "A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line", Diabetes, 52, pp.1147~1154 (2003)
104. Parker, H. E., "Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion", Diabetologia, 55, pp.2445~2455 (2012)
105. Gorboulev, V., "Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion", Diabetes, 61, pp.187~ (2012)
106. Edfalk, S., "Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion", Diabetes, 57, pp.2280~2287 (2008)
107. Hirasawa, A., "Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120", Nat. Med, 11, pp.90~94 (2005)
108. Psichas, A., "Chylomicrons stimulate incretin secretion in mouse and human cells", Diabetologia, 60, pp.2475~2485 (2017)
109. Lu, W. J., "Chylomicron formation and secretion is required for lipidstimulated release of incretins GLP-1 and GIP", Lipids, 47, pp.571~580 (2012)
110. Christensen, L. W., "Vascular, but not luminal, activation of FFAR1(GPR40)stimulates GLP-1 secretion from isolated perfused rat small intestine", Physiol. Rep, 3, pp.e12551~ (2015)
111. Luo, J., "A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents", PLoS ONE, 7, pp.e46300~ (2012)
112. Iwasaki, K., "Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion", Endocrinology, 156, pp.837~846 (2015)
113. Psichas, A., "The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents", Int. J. Obes, 39, pp.424~429 (2015)
114. Hassing, H. A., "Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor", Biofactors, 42, pp.665~673 (2016)
115. Hansen, K. B., "2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1release in humans", J. Clin. Endocrinol. Metab, 96, pp.E1409~E1417 (2011)
116. Mace, O. J., "The regulation of K-and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine", J. Physiol, 590, pp.2917~2936 (2012)
117. Modvig, I. M., "Peptone-mediated glucagon-like peptide-1 secretion depends on intestinal absorption and activation of basolaterally located calcium-sensing receptors", Physiol. Rep, 7, pp.e14056~ (2019)
118. Elrick, H., "Plasma insulin response to oral and intravenous glucose administration", J. Clin. Endocrinol. Metab, 24, pp.1076~1082 (1964)
119. Perley, M. J., "Plasma insulin responses to oral and intravenous glucose : studies in normal and diabetic subjects", J. Clin. Invest, 46, pp.1954~1962 (1967)
120. Leech, C. A., "Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells", Prog. Biophys. Mol. Biol, 107, pp.236~247 (2011)
121. Hansen, L., "Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine", Endocrinology, 140, pp.5356~5363 (1999)
122. Holst, J. J., "The physiology of glucagon-like peptide 1", Physiol. Rev, 87, pp.1409~1439 (2007)
123. Müller, T. D., "Glucagon-like peptide 1(GLP-1)", Mol. Metab, 30, pp.72~130 (2019)
124. Muscogiuri, G., "Glucagon-like peptide-1 and the central", peripheral nervous system : crosstalk in diabetes, 2017, pp.28, 88~103
125. Ionut, V., "Hepatic portal vein denervation impairs oral glucose tolerance but not exenatide’s effect on glycemia", Am. J. Physio. l Endocrinol. Metab, 307, pp.E644~E652 (2014)
126. Hayes, M. R., "The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-likepeptide-1", Am. J. Physiol. Regul. Integr. Comp. Physiol, 301, pp.R1479~R1485 (2011)
127. Varin, E. M., "Distinct neural sites of GLP-1R expression mediate physiological versus pharmacological control of incretin action", Cell Rep, 27, pp.3371~3384.e3 (2019)
128. Krieger, J. P., "Knockdown of GLP-1 receptors in vagal afferents affects normal food intake and glycemia", Diabetes, 65, pp.34~43 (2016)
129. Lamont, B. J., "Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice", J. Clin. Invest, 122, pp.388~402 (2012)
130. Bauer, P. V., "Lactobacillus gasseri in the upper small intestine impacts an ACSL3-dependent fatty acid-sensing pathway regulating whole-body glucose homeostasis", Cell Metab, 27, pp.572~587.e6 (2018)
131. Bauer, P. V., "Metformin alters upper small intestinal microbiota that impact a glucose-SGLT1-sensing glucoregulatory pathway", Cell Metab, 27, pp.101~117.e5 (2018)
132. Baumgartner, I., "Hepatic-portal vein infusions of glucagon-like peptide-1reduce meal size and increase c-Fos expression in the nucleus tractus solitarii, area postrema and central nucleus of the amygdala in rats", J. Neuroendocrinol, 22, pp.557~563 (2010)
133. Rüttimann, E. B., "Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms", Endocrinology, 150, pp.1174~1181 (2009)
134. Gutzwiller, J. P., "Glucagon-like peptide-1 : a potent regulator of food intake in humans", Gut, 44, pp.81~86 (1999)
135. Imeryüz, N., "Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms", Am. J. Physiol, 273, pp.G920~G927 (1997)
136. Abbott, C. R., "The inhibitory effects of peripheral administration of peptide YY(3-36)and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway", Brain Res, 1044, pp.127~131 (2005)
137. Dailey, M. J., "Jejunal linoleic acid infusions require GLP-1 receptor signaling to inhibit food intake : implications for the effectiveness of Roux-en-Y gastric bypass", Am. J. Physiol. Endocrinol. Metab, 301, pp.E1184~E1190 (2011)
138. Adrian, T. E., "Pancreatic polypeptide, glucagon and insulin secretion from the isolated perfused canine pancreas", Diabetologia, 14, pp.413~417 (1978)
139. Taminato, T., "Synthetic gastric inhibitory polypeptide stimulatory effect on insulin and glucagon secretion in the rat", Diabetes, 26, pp.480~484 (1977)
140. Ebert, R., "Effect of exogenous or endogenous gastric inhibitory polypeptide (GIP) on plasma triglyceride responses in rats", Horm. Metab. Res, 23, pp.517~521 (1991)
141. Adriaenssens, A. E., "Glucose-dependent insulinotropic polypeptide receptor-expressing cells in the hypothalamus regulate food intake", Cell Metab, 30, pp.987~996.e6 (2019)
142. Kaneko, K., "Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition", J. Clin. Invest, 129, pp.3786~3791 (2019)
143. Creutzfeldt, W., "Gastric inhibitory polypeptide(GIP)and insulin in obesity : Increased response to stimulation and defective feedback control of serum levels", Diabetologia, 14, pp.15~24 (1978)
144. Falko, J. M., "Gastric inhibitory polypeptide(GIP)stimulated by fat ingestion in man", J. Clin. Endocrinol. Metab, 41, pp.260~265 (1975)
145. Brøns, C., "Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men", J. Physiol, 587, pp.2387~2397 (2009)
146. Suzuki, K., "Transcriptional regulatory factor X6(Rfx6)increases gastric inhibitory polypeptide(GIP)expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity", J. Biol. Chem, 288, pp.1929~1938 (2013)
147. Boylan, M. O., "Gastric inhibitory polypeptide immunoneutralization attenuates development of obesity in mice", Am. J. Physiol. Endocrinol. Metab, 309, pp.E1008~E1018 (2015)
148. Miyawaki, K., "Inhibition of gastric inhibitory polypeptide signaling prevents obesity", Nat. Med, 8, pp.738~742 (2002)
149. Zhang, Q., "The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling", Cell Metab, 33, pp.833~844.e5 (2021)
150. Kim, S. J., "GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis", PLoS ONE, 7, pp.e40156~ (2012)
151. Mroz, P. A., "Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism", Mol. Metab, 20, pp.51~62 (2019)
152. Holst, J. J., "GIP as a therapeutic target in diabetes and obesity: insight from incretin co-agonists", J. Clin. Endocrinol. Metabol, 105, pp.e2710~e2716 (2020)
153. Kuhne, S. G., "Alteration of peptidergic gut-brain signaling under conditions of obesity", J. Physiol. Pharmacol, 5, pp.01~ (2019)
154. Liou, A. P., "The G-protein-coupled receptor GPR40 directly mediates longchain fatty acid-induced secretion of cholecystokinin", Gastroenterology, 140, pp.903~912 (2011)
155. Liou, A. P., "The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells", Am. J. Physiol. Gastrointest. Liver Physiol, 300, pp.G538~G546 (2011)
156. Raybould, H. E., "Inhibition of gastric emptying in response to intestinal lipid is dependent on chylomicron formation", Am. J. Physiol, 274, pp.R1834~R1838 (1998)
157. Burton-Freeman, B., "Interaction of fat availability and sex on postprandial satiety and cholecystokinin after mixed-food meals", Am. J. Clin. Nutr, 80, pp.1207~1214 (2004)
158. French, S. J., "Is cholecystokinin a satiety hormone? Correlations of plasma cholecystokinin with hunger, satiety and gastric emptying in normal volunteers", Appetite, 21, pp.95~104 (1993)
159. Sayegh, A. I., "The role of cholecystokinin receptors in the short-term control of food intake", Prog. Mol. Biol. Transl. Sci, 114, pp.277~316 (2013)
160. Reeve, J. R., "New molecular forms of cholecystokinin. Microsequence analysis of forms previously characterized by chromatographic methods", J. Biol. Chem, 261, pp.16392~16397 (1986)
161. Sayegh, A. I., "CCK-58prolongs the intermeal interval, whereas CCK-8 reduces this interval: not all forms of cholecystokinin have equal bioactivity", Peptides, 55, pp.120~125 (2014)
162. Washington, M. C., "The feeding responses evoked by endogenous cholecystokinin are regulated by different gastrointestinal sites", Horm. Behav, 78, pp.79~85 (2016)
163. Washington, M. C., "Cholecystokinin-33, but not cholecystokinin-8 shows gastrointestinal site specificity in regulating feeding behaviors in male rats", Horm. Behav, 85, pp.36~42 (2016)
164. Sayegh, A. I., "Celiac and the cranial mesenteric arteries supply gastrointestinal sites that regulate meal size and intermeal interval length via cholecystokinin-58 in male rats", Horm. Behav, 67, pp.48~53 (2015)
165. Chandra, R., "Cholecystokinin", Curr. Opin. Endocrinol. Diabetes Obes, 14, pp.63~67 (2007)
166. Degen, L., "Effect of CCK-1 receptor blockade on ghrelin and PYY secretion in men", Am. J. Physiol. Regul. Integr. Comp. Physiol, 292, pp.R1391~R1399 (2007)
167. Feinle, C., "Role of duodenal lipid and cholecystokinin A receptors in the pathophysiology of functional dyspepsia", Gut, 48, pp.347~355 (2001)
168. Feinle, C., "Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans", Am. J. Physiol. Gastrointest. Liver Physiol, 284, pp.G798~G807 (2003)
169. Matzinger, D., "The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans", Gut, 46, pp.688~693 (2000)
170. Ritter, R. C., "Cholecystokinin : proofs and prospects for involvement in control of food intake and body weight", Neuropeptides, 33, pp.387~399 (1999)
171. Schwartz, G. J., "Gastric loads and cholecystokinin synergistically stimulate rat gastric vagal afferents", Am. J. Physiol, 265, pp.R872~R876 (1993)
172. Rogers, R. C., "Mechanisms of action of CCK to activate central vagal afferent terminals", Peptides, 29, pp.1716~1725 (2008)
173. Broberger, C., "Expression and regulation of cholecystokinin and cholecystokinin receptors in rat nodose and dorsal root ganglia", Brain Res, 903, pp.128~140 (2001)
174. Moran, T. H., "Blockade of type A, not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK", Am. J. Physiol, 262, pp.R46~R50 (1992)
175. Pi-Sunyer, X., "C-terminal octapeptide of cholecystokinin decreases food intake in obese men", Physiol. Behav, 29, pp.627~630 (1982)
176. Gibbs, J., "Cholecystokinin decreases food intake in rats", J. Comp. Physiol. Psychol, 84, pp.488~495 (1973)
177. Ritter, R. C., "Capsaicin pretreatment attenuates suppression of food intake by cholecystokinin", Am. J. Physiol, 248, pp.R501~R504 (1985)
178. Smith, G. P., "Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats", Am. J. Physiol, 249, pp.R638~R641 (1985)
179. Diepenbroek, C., "Validation and characterization of a novel method for selective vagal deafferentation of the gut", Am. J. Physiol. Gastrointest. Liver Physiol, 313, pp.G342~G352 (2017)
180. Duca, F. A., "Gut microbiota, nutrient sensing and energy balance", Diabetes Obes. Metab, 16, pp.68~76 (2014)
181. Ritter, R. C., "Increased food intake and CCK receptor antagonists: beyond abdominal vagal afferents", Am. J. Physiol. Regul. Integr. Comp. Physiol, 286, pp.R991~R993 (2004)
182. Yox, D. P., "CCK-receptor antagonists attenuate suppression of sham feeding by intestinal nutrients", Am. J. Physiol, 262, pp.R554~R561 (1992)
183. Blevins, J. E., "Brain regions where cholecystokinin suppresses feeding in rats", Brain Res, 860, pp.1~10 (2000)
184. Hildebrand, P., "The role of cholecystokinin as a regulator of gastrointestinal functions", Praxis, 87, pp.1821~1824 (1998)
185. Beglinger, S., "Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion", J. Clin. Endocrinol. Metab, 95, pp.879~886 (2010)
186. Sakata, Y., "Postabsorptive factors are important for satiation in rats after a lipid meal", Am. J. Physiol, 271, pp.G438~G442 (1996)
187. Bensaıd̈, A., "Protein is more potent than carbohydrate for reducing appetite in rats", Physiol. Behav, 75, pp.577~582 (2002)
188. Caron, J., "Protein digestion-derived peptides and the peripheral regulation of food intake", Front. Endocrinol, 8, pp.85~85 (2017)
189. Ryan, A. T., "Intraduodenal protein modulates antropyloroduodenal motility, hormone release, glycemia, appetite, and energy intake in lean men", Am. J. Clin. Nutr, 96, pp.474~482 (2012)
190. Covasa, M., "Diminished satiation in rats exposed to elevated levels of endogenous or exogenous cholecystokinin", Am. J. Physiol. Regul. Integr. Comp. Physiol, 280, pp.R331~R337 (2001)
191. Reidelberger, R. D., "Effects of peripheral CCK receptor blockade on food intake in rats", Am. J. Physiol. Regul. Integr. Comp. Physiol, 285, pp.R429~R437 (2003)
192. Darcel, N. P., "Activation of vagal afferents in the rat duodenum by protein digests requires PepT1", J. Nutr, 135, pp.1491~1495 (2005)
193. Yox, D. P., "Vagotomy attenuates suppression of sham feeding induced by intestinal nutrients", Am. J. Physiol, 260, pp.R503~R508 (1991)
194. Cheung, G. W., "Intestinal cholecystokinin controls glucose production through a neuronal network", Cell Metab, 10, pp.99~109 (2009)
195. Breen, D. M., "Duodenal PKC-δ and cholecystokinin signaling axis regulates glucose production", Diabetes, 60, pp.3148~3153 (2011)
196. Rasmussen, B. A., "Duodenal activation of cAMP-dependent protein kinase induces vagal afferent firing and lowers glucose production in rats", Gastroenterology, 142, pp.834~843.e3 (2012)
197. Marino, C. R., "Characterization of cAMP-dependent protein kinase activation by CCK in rat pancreas", FEBS Lett, 316, pp.48~52 (1993)
198. Batterham, R. L., "Critical role for peptide YY in protein-mediated satiation and body-weight regulation", Cell Metab, 4, pp.223~233 (2006)
199. Karra, E., "The role of peptide YY in appetite regulation and obesity", J. Physiol, 587, pp.19~25 (2009)
200. Batterham, R. L., "Gut hormone PYY(3-36)physiologically inhibits food intake", Nature, 418, pp.650~654 (2002)
201. Konturek, S. J., "Brain-gut axis and its role in the control of food intake", J. Physiol. Pharmacol, 55, pp.137~154 (2004)
202. Vrang, N., "PYY(3-36)reduces food intake and body weight and improves insulin sensitivity in rodent models of diet-induced obesity", Am. J. Physiol. Regul. Integr. Comp. Physiol, 291, pp.R367~R375 (2006)
203. Chelikani, P. K., "Comparison of the inhibitory effects of PYY(3-36)and PYY(1-36)on gastric emptying in rats", Am. J. Physiol. Regul. Integr. Comp. Physiol, 287, pp.R1064~R1070 (2004)
204. Savage, A. P., "Effects of peptide YY(PYY)on mouth to caecum intestinal transit time and on the rate of gastric emptying in healthy volunteers", Gut, 28, pp.166~170 (1987)
205. Holst, J. J., "Enteroglucagon", Annu. Rev. Physiol, 59, pp.257~271 (1997)
206. Schepp, W., "Oxyntomodulin: a cAMP-dependent stimulus of rat parietal cell function via the receptor for glucagon-like peptide-1 (7-36)NH2", Digestion, 57, pp.398~405 (1996)
207. Baggio, L. L., "Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure", Gastroenterology, 127, pp.546~558 (2004)
208. Dakin, C. L., "Oxyntomodulin inhibits food intake in the rat", Endocrinology, 142, pp.4244~4250 (2001)
209. Du, X., "Differential effects of oxyntomodulin and GLP-1 on glucose metabolism", Am. J. Physiol. Endocrinol. Metab, 303, pp.E265~E271 (2012)
210. Parlevliet, E. T., "Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet", Am. J. Physiol. Endocrinol. Metab, 294, pp.E142~E147 (2008)
211. Pocai, A., "Action and therapeutic potential of oxyntomodulin", Mol. Metab, 3, pp.241~251 (2013)
212. Date, Y., "Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans", Endocrinology, 141, pp.4255~4261 (2000)
213. Ariyasu, H., "Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans", J. Clin. Endocrinol. Metab, 86, pp.4753~4758 (2001)
214. Stengel, A., "Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa", Endocrinology, 150, pp.232~238 (2009)
215. Wren, A. M., "Ghrelin enhances appetite and increases food intake in humans", J. Clin. Endocrinol. Metab, 86, pp.5992~ (2001)
216. Tschöp, M., "Ghrelin induces adiposity in rodents", Nature, 407, pp.908~913 (2000)
217. Wren, A. M., "The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion", Endocrinology, 141, pp.4325~4328 (2000)
218. Tschöp, M., "Post-prandial decrease of circulating human ghrelin levels", J. Endocrinol. Invest, 24, pp.RC19~RC21 (2001)
219. Nakazato, M., "A role for ghrelin in the central regulation of feeding", Nature, 409, pp.194~198 (2001)
220. Date, Y., "The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats", Gastroenterology, 123, pp.1120~1128 (2002)
221. Okada, T., "Analysis of peripheral ghrelin signaling via the vagus nerve in ghrelin receptor–restored GHSR-null mice", Neurosci. Lett, 681, pp.50~55 (2018)
222. Guan, X. -M., "Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues", Mol. Brain Res, 48, pp.23~29 (1997)
223. Banks, W. A., "Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure", J. Pharmacol. Exp. Ther, 302, pp.822~ (2002)
224. Cowley, M. A., "The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis", Neuron, 37, pp.649~661 (2003)
225. Stengel, A., "Ghrelin and NUCB2", nesfatin-1 are expressed in the same gastric cell and differentially correlated with body mass index in obese subjects, 2013, pp.139, 909~918
226. Oh-I, S., "Identification of nesfatin-1 as a satiety molecule in the hypothalamus", Nature, 443, pp.709~712 (2006)
227. Li, Z., "Peripheral effects of nesfatin-1 on glucose homeostasis", PLoS ONE, 8, pp.e71513~ (2013)
228. Shimizu, H., "Peripheral administration of nesfatin-1 reduces food intake in mice : the leptin-independent mechanism", Endocrinology, 150, pp.662~671 (2009)
229. Pan, W., "Nesfatin-1 crosses the blood-brain barrier without saturation", Peptides, 28, pp.2223~2228 (2007)
230. Price, T. O., "Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1", Peptides, 28, pp.2372~2381 (2007)
231. Goebel, M., "Central nesfatin-1 reduces the nocturnal food intake in mice by reducing meal size and increasing inter-meal intervals", Peptides, 32, pp.36~43 (2011)
232. Stengel, A., "Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats : differential role of corticotropin-releasing factor2 receptor", Endocrinology, 150, pp.4911~4919 (2009)
233. Gonzalez, R., "Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet β-and MIN6 cells", J. Endocrinol, 208, pp.R9~R16 (2011)
234. Nakata, M., "Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca(2+)influx through L-type channels in mouse islet β-cells", Endocr. J, 58, pp.305~313 (2011)
235. Grosse, J., "Insulin-like peptide 5 is an orexigenic gastrointestinal hormone", Proc. Natl Acad. Sci. USA, 111, pp.11133~11138 (2014)
236. Lee, Y. S., "Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production", Mol. Metab, 5, pp.263~270 (2016)
237. Schalla, M. A., "Neuroendocrine peptides of the gut and their role in the regulation of food intake", Compr. Physiol, 11, pp.1679~1730 (2021)
238. Cani, P. D., "Microbial regulation of organismal energy homeostasis", Nat. Metab, 1, pp.34~46 (2019)
239. Nicholson, J. K., "Host-gut microbiota metabolic interactions", Science, 336, pp.1262~ (2012)
240. Bäckhed, F., "The gut microbiota as an environmental factor that regulates fat storage", Proc. Natl Acad. Sci. USA, 101, pp.15718~15723 (2004)
241. Bäckhed, F., "Mechanisms underlying the resistance to diet-induced obesity in germ-free mice", Proc. Natl Acad. Sci. USA, 104, pp.979~984 (2007)
242. Duca, F. A., "Current and emerging concepts on the role of peripheral signals in the control of food intake and development of obesity", Br. J. Nutr, 108, pp.778~793 (2012)
243. Arora, T., "Microbial regulation of the L cell transcriptome", Sci. Rep, 8, pp.1207~ (2018)
244. Fredborg, M., "G protein-coupled receptor120(GPR120) transcription in intestinal epithelial cells is significantly affected by bacteria belonging to the Bacteroides, Proteobacteria, and Firmicutes phyla", J. Anim. Sci, 90(Suppl 4), pp.10~12 (2012)
245. McVey Neufeld, K. A., "The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse", Neurogastroenterol. Motil, 25, pp.183~e88 (2013)
246. McVey Neufeld, K. A., "The gut microbiome restores intrinsic and extrinsic nerve function in germ-free mice accompanied by changes in calbindin", Neurogastroenterol. Motil, 27, pp.627~636 (2015)
247. Anitha, M., "Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling", Gastroenterology, 143, pp.1006~1016.e4 (2012)
248. Barajon, I., "Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia", J. Histochem Cytochem, 57, pp.1013~1023 (2009)
249. De Vadder, F., "Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks", Proc. Natl Acad. Sci. USA, 115, pp.6458~6463 (2018)
250. David, L. A., "Diet rapidly and reproducibly alters the human gut microbiome", Nature, 505, pp.559~563 (2014)
251. Ley, R. E., "Obesity alters gut microbial ecology", Proc. Natl Acad. Sci. USA, 102, pp.11070~11075 (2005)
252. Turnbaugh, P. J., "An obesity-associated gut microbiome with increased capacity for energy harvest", Nature, 444, pp.1027~1031 (2006)
253. Ridaura, V. K., "Gut microbiota from twins discordant for obesity modulate metabolism in mice", Science, 341, pp.1241214~ (2013)
254. Vrieze, A., "Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome", Gastroenterology, 143, pp.913~916.e7 (2012)
255. Cani, P. D., "Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability", Gut, 58, pp.1091~1103 (2009)
256. Everard, A., "Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice", Diabetes, 60, pp.2775~2786 (2011)
257. Cani, P. D., "Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor", Diabetes, 55, pp.1484~1490 (2006)
258. Delzenne, N. M., "Impact of inulin and oligofructose on gastrointestinal peptides", Br. J. Nutr, 93(Suppl 1), pp.S157~S161 (2005)
259. Cani, P. D., "Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation(glucagon-like peptide-1and ghrelin)in rats", Br. J. Nutr, 92, pp.521~526 (2004)
260. Cani, P. D., "Oligofructose promotes satiety in healthy human : a pilot study", Eur. J. Clin. Nutr, 60, pp.567~572 (2006)
261. Singh, A., "Inulin fiber dose-dependently modulates energy balance, glucose tolerance, gut microbiota, hormones and diet preference in high-fat-fed male rats", J. Nutr. Biochem, 59, pp.142~152 (2018)
262. Cani, P. D., "Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia", Diabetologia, 50, pp.2374~2383 (2007)
263. Hosoi, T., "Novel pathway for LPS-induced afferent vagus nerve activation : Possible role of nodose ganglion", Auton. Neurosci, 120, pp.104~107 (2005)
264. de La Serre, C. B., "Chronic exposure to low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons", Physiol. Behav, 139, pp.188~194 (2015)
265. de Lartigue, G., "Dietinduced obesity leads to the development of leptin resistance in vagal afferent neurons", Am. J. Physiol. Endocrinol. Metab, 301, pp.E187~E195 (2011)
266. Peters, J. H., "Cooperative activation of cultured vagal afferent neurons by leptin and cholecystokinin", Endocrinology, 145, pp.3652~3657 (2004)
267. Peters, J. H., "Leptin and CCK selectively activate vagal afferent neurons innervating the stomach and duodenum", Am. J. Physiol. Regul. Integr. Comp. Physiol, 290, pp.R1544~R1549 (2006)
268. de Lartigue, G., "Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats", PLoS ONE, 7, pp.e32967~ (2012)
269. Thomas, C., "Targeting bile-acid signalling for metabolic diseases", Nat. Rev. Drug Discov, 7, pp.678~693 (2008)
270. Trabelsi, M. -S., "Intestinal bile acid receptors are key regulators of glucose homeostasis", Proc. Nutr. Soc, 76, pp.192~202 (2017)
271. Trabelsi, M. -S., "Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells", Nat. Commun, 6, pp.7629~7629 (2015)
272. Zhang, S. Y., "FXR in the dorsal vagal complex is sufficient and necessary for upper small intestinal microbiome-mediated changes of TCDCA to alter insulin action in rats", Gut, 70, pp.1675~1683 (2021)
273. Waise, T. M. Z., "Small intestinal taurochenodeoxycholic acid-FXR axis alters local nutrient-sensing glucoregulatory pathways in rats", Mol. Metab, 44, pp.101132~ (2021)
274. Fang, S., "Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance", Nat. Med, 21, pp.159~165 (2015)
275. Pathak, P., "Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism", Hepatology, 68, pp.1574~1588 (2018)
276. Pathak, P., "Farnesoid X receptor induces Takeda G-protein receptor 5 crosstalk to regulate bile acid synthesis and hepatic metabolism", J. Biol. Chem, 292, pp.11055~11069 (2017)
277. Katsuma, S., "Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1", Biochem. Biophys. Res. Commun, 329, pp.386~390 (2005)
278. den Besten, G., "Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation", Diabetes, 64, pp.2398~2408 (2015)
279. Lu, Y., "Short chain fatty acids prevent high-fat-diet-induced obesity in mice by regulating G protein-coupled receptors and gut microbiota", Sci. Rep, 6, pp.37589~ (2016)
280. Li, Z., "Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit", Gut, 67, pp.1269~1279 (2018)
281. Tolhurst, G., "Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2", Diabetes, 61, pp.364~371 (2012)
282. Brooks, L., "Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety", Mol. Metab, 6, pp.48~60 (2017)
283. Larraufie, P., "SCFAs strongly stimulate PYY production in human enteroendocrine cells", Sci. Rep, 8, pp.74~74 (2018)
284. Petersen, N., "Generation of L cells in mouse and human small intestine organoids", Diabetes, 63, pp.410~420 (2014)
285. Nøhr, M. K., "Expression of the short chain fatty acid receptor GPR41", FFAR3 in autonomic and somatic sensory ganglia, 2015, pp.290, 126~137
286. Frost, G., "The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism", Nat. Commun, 5, pp.3611~ (2014)
287. Wikoff, W. R., "Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites", Proc. Natl Acad. Sci. USA, 106, pp.3698~3703 (2009)
288. Côté, F., "Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function", Proc. Natl Acad. Sci. USA, 100, pp.13525~13530 (2003)
289. Blackshaw, L. A., "Sensory transmission in the gastrointestinal tract", Neurogastroenterol. Motil, 19, pp.1~19 (2007)
290. Hillsley, K., "Serotonin and cholecystokinin activate different populations of rat mesenteric vagal afferents", Neurosci. Lett, 255, pp.63~66 (1998)
291. Zhu, J. X., "Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat", J. Physiol, 530, pp.431~442 (2001)
292. Kirchgessner, A. L., "Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivity", J. Neurosci, 12, pp.235~ (1992)
293. Michel, K., "Subpopulations of gastric myenteric neurons are differentially activated via distinct serotonin receptors : projection, neurochemical coding, and functional implications", J. Neurosci, 17, pp.8009~ (1997)
294. Mazda, T., "Gastric distension-induced release of 5-HT stimulates c-fos expression in specific brain nuclei via 5-HT3receptors in conscious rats", Am. J. Physiol. Gastrointest. Liver Physiol, 287, pp.G228~G235 (2004)
295. Bellono, N. W., "Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways", Cell, 170, pp.185~198.e16 (2017)
296. Barrett, E., "γ-Aminobutyric acid production by culturable bacteria from the human intestine", J. Appl. Microbiol, 113, pp.411~417 (2012)
297. Meng, F., "New inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism", Proc. Natl Acad. Sci. USA, 113, pp.3645~3650 (2016)
298. Tian, J., "Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice", PLoS ONE, 6, pp.e25338~ (2011)
299. Yunes, R. A., "GABA production and structure of gadB", gadC genes in Lactobacillus and Bifidobacterium strains from human microbiota, 2016, pp.42, 197~204
300. Kootte, R. S., "Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition", Cell Metab, 26, pp.611~619.e6 (2017)
301. Marques, T. M., "Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model", Benef. Microbes, 7, pp.409~420 (2016)
302. Mojibian, M., "Engineering the gut for insulin replacement to treat diabetes", J. Diabetes Investig, 7(Suppl 1), pp.87~93 (2016)
303. Bouchi, R., "FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures", Nat. Commun, 5, pp.4242~ (2014)
304. Talchai, C., "Generation of functional insulin-producing cells in the gut by Foxo1 ablation", Nat. Genet, 44, pp.406~412 (2012)
305. Chen, Z., "Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity", J. Clin. Invest, 124, pp.3391~3406 (2014)
306. Ramachandran, G., "Editing the microbiome the CRISPR way", Philos. Trans. R. Soc. Lond. B. Biol. Sci, 374, pp.20180103~ (2019)
307. Wang, L., "Engineered bacteria of MG1363-pMG36e-GLP-1 attenuated obesity-induced by high fat diet in mice", Front. Cell. Infect. Microbiol, 11, pp.595575~ (2021)
308. Li, B., "Microbiota depletion impairs thermogenesis of brown adipose tissue and browning of white adipose tissue", Cell Rep, 26, pp.2720~2737.e5 (2019)
309. Wen, J., "Thermo-TRPs and gut microbiota are involved in thermogenesis and energy metabolism during low temperature exposure of obese mice", J. Exp. Biol, 223, pp.jeb218974~ (2020)
310. Blouet, C., "Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats", PLoS ONE, 7, pp.e51898~ (2012)
311. Grasset, E., "The gut microbiota to the brain axis in the metabolic control", Rev. Endocr. Metab. Disord, 20, pp.427~438 (2019)

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