농약 노출과 건강
Pesticide Exposure and Health
2
조회
0
다운로드
27
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0
참고문헌
키워드
초록
Although pesticides have increased crop production and controlled disease, they have produced a number of adverse health effects. Pesticides have potential human toxicity and a variety of groups, such as farmers or industrial workers, as well as the general population, are exposed to pesticides. The purpose of this article, therefore, is to provide an overview of pesticide exposure and health through a literature review, focusing on exposure assessment,acute poisoning, chronic health effects, and future research needs. The exposure types and levels of pesticides vary by study subjects and need to be assessed by integrating several methods focused on the epidemiological purpose. Acute pesticide poisoning is a major public health problem in the world. Paraquat is the main causative pesticide for acute poisoning in Korea and should be banned in order to save several thousands of lives every year. Occupational pesticide exposure also causes numerous chronic diseases among farmers and industrial workers, including cancers, respiratory diseases, depression, retinal degeneration, diabetes, and abnormal menstrual cycle. However,controversy exists regarding the long-term effects of low-dose environmental pesticide exposure. The area of pesticide study is relatively new with broad study populations and it has received little academic and policy attention,particularly in Korea. More detailed studies investigating the risk of pesticide-related health effects and intervention efforts to reduce the problems are needed in Korea
Abstract
Although pesticides have increased crop production and controlled disease, they have produced a number of adverse health effects. Pesticides have potential human toxicity and a variety of groups, such as farmers or industrial workers, as well as the general population, are exposed to pesticides. The purpose of this article, therefore, is to provide an overview of pesticide exposure and health through a literature review, focusing on exposure assessment,acute poisoning, chronic health effects, and future research needs. The exposure types and levels of pesticides vary by study subjects and need to be assessed by integrating several methods focused on the epidemiological purpose. Acute pesticide poisoning is a major public health problem in the world. Paraquat is the main causative pesticide for acute poisoning in Korea and should be banned in order to save several thousands of lives every year. Occupational pesticide exposure also causes numerous chronic diseases among farmers and industrial workers, including cancers, respiratory diseases, depression, retinal degeneration, diabetes, and abnormal menstrual cycle. However,controversy exists regarding the long-term effects of low-dose environmental pesticide exposure. The area of pesticide study is relatively new with broad study populations and it has received little academic and policy attention,particularly in Korea. More detailed studies investigating the risk of pesticide-related health effects and intervention efforts to reduce the problems are needed in Korea
참고문헌 (56)
- Dawson AH, "Acute human lethal toxicity of agricultural pesticides: a prospective cohort study", PLoS Med, 7(10), pp.e1000357~ (2010)
- Lee WJ, "Cancer incidence among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study", J Natl Cancer Inst, 96(23), pp.1781~1789 (2004)
- "Pesticides industry sales and usage. 2006 and 2007 market estimates"[URL]
- "Pesticide handbook 2009"[URL]
- Alavanja MC, "Health effects of chronic pesticide exposure: cancer and neurotoxicity", Annu Rev Public Health, 25, pp.155~197 (2004)
- Dosemeci M, "A quantitative approach for estimating exposure to pesticides in the Agricultural Health Study", Ann Occup Hyg, 46(2), pp.245~260 (2002)
- Thomas KW, "Assessment of a pesticide exposure intensity algorithm in the Agricultural Health Study", J Expo Sci Environ Epidemiol, 20(6), pp.559~569 (2010)
- Maroni M, "Biological monitoring of pesticide exposure: a review", Toxicology, 143(1), pp.1~118 (2000)
- 이요한, "일부 농업인에서 자기 기입식 농약 노출 설문에 대한 신뢰도 연구", 예방의학회지, 43(6), pp.535~542 (2010), 대한예방의학회
- 김현중, "일부 농업인에서의 농약 중독증상과 농약 사용정보에 대한 예비조사", 한국환경보건학회지, 37(1), pp.22~28 (2011), 한국환경보건학회
- Blair A, "Epidemiologic studies in agricultural populations: observations and future directions", J Agromedicine, 14(2), pp.125~131 (2009)
- Jeyaratnam J, "Acute pesticide poisoning: a major global health problem", World Health Stat Q, 43(3), pp.139~144 (1990)
- Gunnell D, "The global distribution of fatal pesticide self-poisoning: systematic review", BMC Public Health, 7, pp.357~ (2007)
- Lee WJ, "Deaths from pesticide poisoning in South Korea: trends over 10 years", Int. Arch. Occup. Environ. Health, 82(3), pp.365~371 (2009)
- Lee WJ, "Overview of pesticide poisoning in South Korea", J Rural Med, 4(2), pp.53~58 (2009)
- Researches on the actual state of pesticide poisoning in Korea and guidelines for diagnosis and treatment of paraquat and organophosphate poisoning, "Rural Development Administration", Rural Development Administration, ~ (2008)
- Lock EA, "Paraquat, In Hayes' Handbook of Pesticide Toxicology, 3rd ed", pp.1771~1827 (2010), Academic Press
- "Agricultural Health Study"[URL]
- Occupational exposures in insecticide application, and some pesticides. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, "International Agency for Research on Cancer", IARC Monogr Eval Carcinog Risks Hum, 5~586 (1991)
- Weichenthal S, "A review of pesticide exposure and cancer incidence in the Agricultural Health Study cohort", Environ Health Perspect, 118(8), pp.1117~1125 (2010)
- Jones DR, "Systematic review and meta-analysis of mortality in crop protection product manufacturing workers", Occup Environ Med, 66(1), pp.7~15 (2009)
- Lee WJ, "Pesticides and Cancer, In Encyclopedia of Cancer and Society", pp.670~673 (2007), SAGE publications
- Cohn BA, "DDT and breast cancer in young women: new data on the significance of age at exposure", Environ Health Perspect, 115(10), pp.1406~1414 (2007)
- Infante-Rivard C, "Pesticides and childhood cancer: an update of Zahm and Ward's 1998 review", J Toxicol Environ Health B Crit Rev, 10(1), pp.81~99 (2007)
- 설재웅, "농약사용과 암발생과의 관계", 예방의학회지, 35(1), pp.24~32 (2002), 대한예방의학회
- Lee WJ, "Cancer mortality and farming in South Korea: an ecologic study", CANCER CAUSE CONTROL, 19(5), pp.505~513 (2008)
- 이원진, "Disease Prevalence and Mortality among Agricultural Workers in Korea", Journal of Korean Medical Science, 25, pp.112~118 (2010), 대한의학회
- Beseler CL, "A cohort study of pesticide poisoning and depression in Colorado farm residents", Ann Epidemiol, 18(10), pp.768~774 (2008)
- Beseler C, "Depression and pesticide exposures in female spouses of licensed pesticide applicators in the Agricultural Health Study cohort", J Occup Environ Med, 48(10), pp.1005~1013 (2006)
- London L, "Suicide and exposure to organophosphate insecticides: cause or effect", Am J Ind Med, 47(4), pp.308~321 (2005)
- Lee WJ, "Mortality among pesticide applicators exposed to chlorpyrifos in the agricultural health study", ENVIRON HEALTH PERSPECT, 115(4), pp.528~534 (2007), NIEHS
- Brown TP, "Pesticides and Parkinson's disease--is there a link", Environ Health Perspect, 114(2), pp.156~164 (2006)
- Park J, "Occupations and Parkinson's disease: A multi-center case-control study in South Korea", NEUROTOXICOLOGY, 26(1), pp.99~105 (2005), ELSEVIER SCIENCE BV
- Park SK, "Occupational exposure to pesticides and nerve conduction studies among farmers", Arch Environ Occup Health
- Hoppin JA, "Pesticides and adult respiratory outcomes in the Agricultural Health Study", Ann N Y Acad Sci, 1076, pp.343~354 (2006)
- Peiris-John RJ, "Low-level exposure to organophosphate pesticides leads to restrictive lung dysfunction", Respir Med, 99(10), pp.1319~1324 (2005)
- Taylor JT, "Acute toxic effects of inhaled dichlorvos vapor on respiratory mechanics and blood cholinesterase activity in guinea pigs", Inhal Toxicol, 20(5), pp.465~472 (2008)
- Chakraborty S, "Chronic exposures to cholinesterase-inhibiting pesticides adversely affect respiratory health of agricultural workers in India", J Occup Health, 51(6), pp.488~497 (2009)
- Chatzi L, "Association of allergic rhinitis with pesticide use among grape farmers in Crete, Greece", Occup Environ Med, 64(6), pp.417~421 (2007)
- Sheiner EK, "Effect of occupational exposures on male fertility: literature review", Ind Health, 41(2), pp.55~62 (2003)
- Farr SL, "Pesticide exposure and timing of menopause", Am J Epidemiol, 163(8), pp.731~742 (2006)
- Damgaard IN, "Persistent pesticides in human breast milk and cryptorchidism", Environ Health Perspect, 114(7), pp.1133~1138 (2006)
- Steerenberg P, "Toxicological evaluation of the immune function of pesticide workers, a European wide assessment", Hum Exp Toxicol, 27(9), pp.701~707 (2008)
- Kamel F, "Retinal degeneration in licensed pesticide applicators", Am J Ind Med, 37(6), pp.618~628 (2000)
- Montgomery MP, "Incident diabetes and pesticide exposure among licensed pesticide applicators: Agricultural Health Study, 1993-2003", Am J Epidemiol, 167(10), pp.1235~1246 (2008)
- Mackness B, "Paraoxonase and susceptibility to organophosphorus poisoning in farmers dipping sheep", Pharmacogenetics, 13(2), pp.81~88 (2003)
- Eskenazi B, "PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in utero", Environ Health Perspect, 118(12), pp.1775~1781 (2010)
- "Third National Report on Human Exposure to Environmental Chemicals"[URL]
- Swirsky Gold L, "Pesticide residues in food: investigation of disparities in cancer risk estimates", Cancer Lett, 117(2), pp.195~207 (1997)
- Chun OK, "Estimation of risks of pesticide exposure, by food intake, to Koreans", Food Chem Toxicol, 41(8), pp.1063~1076 (2003)
- Ames BN, "Environmental pollution, pesticides, and the prevention of cancer: misconceptions", FASEB J, 11(13), pp.1041~1052 (1997)
- Tomatis L, "Alleged misconceptions' distort perceptions of environmental cancer risks", FASEB J, 15(1), pp.195~203 (2001)
- "AGRICOH: A Consortium of Agricultural Cohort Studies"[URL]
- Lee WJ, "Occupational exposure to pesticides, asthma history, and the risk of non-Hodgkin lymphoma", Int J Cancer, 118(12), pp.3174~3176 (2006)
- Rosas LG, "Pesticides and child neurodevelopment", Curr Opin Pediatr, 20(2), pp.191~197 (2008)
- Cox C, "Unidentified inert ingredients in pesticides: implications for human and environmental health", Environ Health Perspect, 114(12), pp.1803~1806 (2006)
