Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-β-mediated Smad2/3 phosphorylation

참고문헌 (49)

1. Hartvigsen, J., "What low back pain is and why we need to pay attention", Lancet, 391, pp.2356~2367 (2018)
2. Walker, B. F., "The prevalence of low back pain : a systematic review of the literature from 1966 to 1998", J. Spinal Disord, 13, pp.205~217 (2000)
3. Knezevic, N. N., "Low back pain", Lancet, 398, pp.78~92 (2021)
4. Global Burden of Disease Study 2013 Collaborators, "Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013", Lancet, 386, pp.743~800 (2015)
5. Chou, D., "Degenerative magnetic resonance imaging changes in patients with chronic low back pain : a systematic review", Spine, 36, pp.S43~S53 (2011)
6. Binch, A., "Cell-based strategies for IVD repair: clinical progress and translational obstacles", Nat. Rev. Rheumatol, 17, pp.158~175 (2021)
7. Wang, Y., "The role of IL-1β and TNF-α in intervertebral disc degeneration", Biomed. Pharmacother, 131, pp.110660~ (2020)
8. Risbud, M. V., "Role of cytokines in intervertebral disc degeneration : pain and disc content", Nat. Rev. Rheumatol, 10, pp.44~56 (2014)
9. Wang, J., "Tumor necrosis factor α-and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1", Arthritis Rheum, 65, pp.832~842 (2013)
10. Chen, F., "Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β", NF-κB-NLRP3 inflammasome positive feedback loop, 2020, pp.8, 10~
11. Lyu, F. J., "Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions", Bone Res, 9, pp.7~ (2021)
12. Park, S. A., "Gremlin-1 augments the oestrogen-related receptor α signalling through EGFR activation : implications for the progression of breast cancer", Br. J. Cancer, 123, pp.988~999 (2020)
13. Gazzerro, E., "Conditional deletion of gremlin causes a transient increase in bone formation and bone mass", J. Biol. Chem, 282, pp.31549~31557 (2007)
14. Sung, N. J., "Gremlin-1 promotes metastasis of breast cancer cells by activating STAT3-MMP13 signaling pathway", Int. J. Mol. Sci, 21, pp.9227~ (2020)
15. Qu, S., "Down-regulation of Gremlin1 inhibits inflammatory response and vascular permeability in chronic idiopathic urticaria through suppression of TGF-β signaling pathway", Gene, 756, pp.144916~ (2020)
16. Chang, S. H., "Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway", Nat. Commun, 10, pp.1442~ (2019)
17. Huang, X., "Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis", Osteoarthr. Cartil, 26, pp.834~843 (2018)
18. Iijima, H., "Physiological exercise loading suppresses post-traumatic osteoarthritis progression via an increase in bone morphogenetic proteins expression in an experimental rat knee model", Osteoarthr. Cartil, 25, pp.964~975 (2017)
19. Leijten, J. C., "Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis", Arthritis Rheum, 64, pp.3302~3312 (2012)
20. Jiang, R., "Circ_DHRS3 positively regulates GREM1 expression by competitively targeting miR-183-5p to modulate IL-1β-administered chondrocyte proliferation, apoptosis and ECM degradation", Int. Immunopharmacol, 91, pp.107293~ (2021)
21. Chan, S. C., "Osteogenic differentiation of bone marrow stromal cells is hindered by the presence of intervertebral disc cells", Arthritis Res. Ther, 18, pp.29~ (2015)
22. Tekari, A., "The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells", Eur. Cells Mater, 33, pp.197~210 (2017)
23. Wen, T., "Bone mesenchymal stem cell-derived extracellular vesicles promote the repair of intervertebral disc degeneration by transferring microRNA-199a", Cell Cycle, 20, pp.256~270 (2021)
24. Sabbadini, F., "The multifaceted role of TGF-β in gastrointestinal tumors", Cancers(Basel), 13, pp.3960~ (2021)
25. Hu, H. H., "New insights into TGF-β", Smad signaling in tissue fibrosis, 2018, pp.292, 76~83
26. Shen, J., "TGF-β signaling and the development of osteoarthritis", Bone Res, 2, pp.14002~14002 (2014)
27. Zhou, X., "Biochemical signals mediate the crosstalk between cartilage and bone in osteoarthritis", Biomed. Res. Int, 2020, pp.5720360~ (2020)
28. Ling, H., "Osteoking decelerates cartilage degeneration in DMM-induced osteoarthritic mice model through TGF-β", smad-dependent manner, 2021, pp.12, 678810~
29. Chen, S., "TGF-β signaling in intervertebral disc health and disease", Osteoarthr. Cartil, 27, pp.1109~1117 (2019)
30. Wu, T., "Krüppel like factor 10 prevents intervertebral disc degeneration via TGF-β signaling pathway both in vitro and in vivo", J. Orthop. Translat, 29, pp.19~29 (2021)
31. Xiao, L., "TGF-β", SMAD signaling inhibits intermittent cyclic mechanical tension-induced degeneration of endplate chondrocytes by regulating the miR-455-5p, J. Cell. Biochem, pp.2018, 119[DOI]
32. Li, Z., "Both expression of cytokines and posterior annulus fibrosus rupture are essential for pain behavior changes induced by degenerative intervertebral disc : An experimental study in rats", J. Orthop. Res, 32, pp.262~272 (2014)
33. Kazezian, Z., "Gene expression profiling identifies interferon signalling molecules and IGFBP3 in human degenerative annulus fibrosus", Sci. Rep, 5, pp.15662~ (2015)
34. Vlaeyen, J., "Low back pain", Nat. Rev. Dis. Prim, 4, pp.52~ (2018)
35. Kamali, A., "Small molecule-based treatment approaches for intervertebral disc degeneration : Current options and future directions", Theranostics, 11, pp.27~47 (2021)
36. Duffy, L., "Bone morphogenetic protein antagonist gremlin-1 increases myofibroblast transition in dermal fibroblasts : implications for systemic sclerosis", Front. Cell. Dev. Biol, 9, pp.681061~ (2021)
37. Kišonaitė, M., "Structure of gremlin-1 and analysis of its interaction with BMP-2", Biochem. J, 473, pp.1593~1604 (2016)
38. Church, R. H., "Gremlin1 plays a key role in kidney development and renal fibrosis", Am. J. Physiol. -Ren. Physiol, 312, pp.F1141~F1157 (2017)
39. Jia, S., "TGFβ family signaling and development", Development, 148, pp.dev188490~ (2021)
40. Liu, S., "Targeting TGFβ signal transduction for cancer therapy", Signal Transduct. Target. Ther, 6, pp.8~ (2021)
41. Swarup Mitra, "Neuroadaptations and TGF-β signaling: emerging role in models of neuropsychiatric disorders", Molecular Psychiatry, 27(1), pp.296~306 (2021), Springer Science and Business Media LLC[DOI]
42. Aashaq, S., "TGF-β signaling : A recap of SMAD-independent and SMADdependent pathways", J. Cell Physiol, 237, pp.59~85 (2021)
43. Hata, A., "TGF-β signaling from receptors to Smads", Cold Spring Harbor Perspect. Biol, 8, pp.a022061~ (2016)
44. van der Kraan, P. M., "The changing role of TGFβ in healthy, ageing and osteoarthritic joints", Nat. Rev. Rheumatol, 13, pp.155~163 (2017)
45. Yang, H., "TNF-α and TGF-β1 regulate Syndecan-4 expression in nucleus pulposus cells : role of the mitogen-activated protein kinase and NF-κB pathways", Connect. Tissue Res, 56, pp.281~287 (2015)
46. Cui, H., "Visfatin promotes intervertebral disc degeneration by inducing IL-6expression through the ERK", JNK, Adipocyte, pp.2021, 10[DOI]
47. Long, J., "JAG2", Notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix, 2019, pp.21, 213~
48. Zhang, J., "TNF-α enhances apoptosis by promoting chop expression in nucleus pulposus cells : role of the MAPK and NF-κB pathways", J. Orthop. Res, 37, pp.697~705 (2019)
49. Li, Z., "Wnt5a suppresses inflammation-driven intervertebral disc degeneration via a TNF-α", NF-κB-Wnt5a negative-feedback loop, 2018, pp.26, 966~977

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