Augmentation of the RNA m6A reader signature is associated with poor survival by enhancing cell proliferation and EMT across cancer types

참고문헌 (71)

1. Hanahan, D., "Hallmarks of cancer : the next generation", Cell, 144, pp.646~674 (2011)
2. Zaccara, S., "Reading, writing and erasing mRNA methylation", Nat. Rev. Mol. Cell Biol, 20, pp.608~624 (2019)
3. Liu, J., "A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation", Nat. Chem. Biol, 10, pp.93~95 (2014)
4. Knuckles, P., "Zc3h13", Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15, Fl(2)d, pp.Genes Dev, 2018[DOI]
5. Jia, G., "N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO", Nat. Chem. Biol, 7, pp.885~887 (2011)
6. Yang, S., "m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade", Nat. Commun, 10, pp.2782~ (2019)
7. Kretschmer, J., "The m(6)A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5’–3’ exoribonuclease XRN1", RNA, 24, pp.1339~1350 (2018)
8. Seung Hun Han, "Diverse molecular functions of m6A mRNA modification in cancer", Experimental and Molecular Medicine, 52, pp.1~12 (2020), 생화학분자생물학회[DOI]
9. Ma, J. Z., "METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N(6)-methyladenosine-dependent primary MicroRNA processing", Hepatology, 65, pp.529~543 (2017)
10. Sun, T., "LNC942 promoting METTL14-mediated m(6)A methylation in breast cancer cell proliferation and progression", Oncogene, 39, pp.5358~5372 (2020)
11. He, L., "Functions of N6-methyladenosine and its role in cancer", Mol. Cancer, 18, pp.176~ (2019)
12. Huang, Y., "Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia", Cancer Cell, 35, pp.677~691.e610 (2019)
13. Yankova, E., "Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia", Nature, 593, pp.597~601 (2021)
14. Xu, X., "Differential gene expression profiling of gastric intraepithelial neoplasia and early-stage adenocarcinoma", World J. Gastroenterol, 20, pp.17883~17893 (2014)
15. Delgado, J., "Survival analysis in hematologic malignancies : recommendations for clinicians", Haematologica, 99, pp.1410~1420 (2014)
16. Desmedt, C., "Multifactorial approach to predicting resistance to anthracyclines", J. Clin. Oncol, 29, pp.1578~1586 (2011)
17. Tripathi, M. K., "Nuclear factor of activated T-cell activity is associated with metastatic capacity in colon cancer", Cancer Res, 74, pp.6947~6957 (2014)
18. Murat, A., "Stem cell-related"self-renewal"signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma", J. Clin. Oncol, 26, pp.3015~3024 (2008)
19. Okayama, H., "Identification of genes upregulated in ALK-positive and EGFR", KRAS, Cancer Res, pp.2012, 72[DOI]
20. Bueno, R., "Multi-institutional prospective validation of prognostic mRNA signatures in early stage squamous lung cancer(alliance)", J. Thorac. Oncol, 15, pp.1748~1757 (2020)
21. Gentric, G., "PML-regulated mitochondrial metabolism enhances chemosensitivity in human ovarian cancers", Cell Metab, 29, pp.156~173.e110 (2019)
22. Cristescu, R., "Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes", Nat. Med, 21, pp.449~456 (2015)
23. Gautier, L., "affy-analysis of Affymetrix GeneChip data at the probe level", Bioinformatics, 20, pp.307~315 (2004)
24. Dobin, A., "STAR : ultrafast universal RNA-seq aligner", Bioinformatics, 29, pp.15~21 (2013)
25. Xu, K., "Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis", Oncogenesis, 10, pp.66~ (2021)
26. Zhang, Y. P., "Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response", Proc. Natl Acad. Sci. USA, 118, pp.e2103240118~ (2021)
27. Kumar, V., "Single-cell atlas of lineage states, tumor microenvironment, and subtype-specific expression programs in gastric cancer", Cancer Discov, 12, pp.670~691 (2022)
28. Wu, F., "Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer", Nat. Commun, 12, pp.2540~ (2021)
29. Korsunsky, I., "Fast, sensitive and accurate integration of single-cell data with Harmony", Nat. Methods, 16, pp.1289~1296 (2019)
30. Stuart, T., "Comprehensive integration of single-cell data", Cell, 177, pp.1888~1902.e21 (2019)
31. Goldman, M. J., "Visualizing and interpreting cancer genomics data via the Xena platform", Nat. Biotechnol, 38, pp.675~678 (2020)
32. Sledz, P., "Structural insights into the molecular mechanism of the m(6)A writer complex", Elife, 5, pp.e18434~ (2016)
33. Beroukhim, R., "Assessing the significance of chromosomal aberrations in cancer : methodology and application to glioma", Proc. Natl. Acad. Sci. USA, 104, pp.20007~20012 (2007)
34. Li, Y., "Molecular characterization and clinical relevance of m(6)A regulators across 33 cancer types", Mol. Cancer, 18, pp.137~ (2019)
35. Girolami, I., "The activation status of the TGF-beta transducer Smad 2 is associated with a reduced survival in gastrointestinal cancers : A systematic review and meta-analysis", Int. J. Mol. Sci, 20, pp.3831~ (2019)
36. Teeuwssen, M., "Wnt signaling in ovarian cancer stemness, EMT, and therapy resistance", J. Clin. Med, 8, pp.1658~ (2019)
37. Tulchinsky, E., "EMT: a mechanism for escape from EGFR-targeted therapy in lung cancer", Biochim. Biophys. Acta Rev. Cancer, 1871, pp.29~39 (2019)
38. Jung, A. R., "Epithelial-mesenchymal transition gene signature is associated with prognosis and tumor microenvironment in head and neck squamous cell carcinoma", Sci. Rep, 10, pp.3652~ (2020)
39. Lin, Y., "Tumor-associated macrophages in tumor metastasis : biological roles and clinical therapeutic applications", J. Hematol. Oncol, 12, pp.76~ (2019)
40. Fu, X. L., "Interleukin 6 induces M2 macrophage differentiation by STAT3activation that correlates with gastric cancer progression", Cancer Immunol. Immunother, 66, pp.1597~1608 (2017)
41. Saraiva, A. L., "New insights into the role of tissue eosinophils in the progression of colorectal cancer: a literature review", Acta Med. Port, 31, pp.329~337 (2018)
42. Bell, J. L., "IGF2BP1 harbors prognostic significance by gene gain and diverse expression in neuroblastoma", J. Clin. Oncol, 33, pp.1285~1293 (2015)
43. Cao, J., "The roles of insulin-like growth factor 2 mRNA-binding protein 2 in cancer and cancer stem cells", Stem Cells Int, 2018, pp.4217259~ (2018)
44. Ye, S., "IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering with RAF-1 degradation by miR-195", FEBS Lett, 590, pp.1641~1650 (2016)
45. Muller, S., "The oncofetal RNA-binding protein IGF2BP1 is a druggable, posttranscriptional super-enhancer of E2F-driven gene expression in cancer", Nucleic Acids Res, 48, pp.8576~8590 (2020)
46. Ribatti, D., "Epithelial-mesenchymal transition in cancer : a historical overview", Transl. Oncol, 13, pp.100773~ (2020)
47. Lederer, M., "The role of the oncofetal IGF2 mRNA-binding protein 3(IGF2BP3)in cancer", Semin. Cancer Biol, 29, pp.3~12 (2014)
48. Barghash, A., "Overexpression of IGF2 mRNA-binding protein 2(IMP2", p62)as a feature of basal-like breast cancer correlates with short survival, 2015, pp.82, 142~143
49. Kobel, M., "Expression of the RNA-binding protein IMP1 correlates with poor prognosis in ovarian carcinoma", Oncogene, 26, pp.7584~7589 (2007)
50. Voutsadakis, I. A., "Hormone receptors in serous ovarian carcinoma : Prognosis, pathogenesis, and treatment considerations", Clin. Med. Insights Oncol, 10, pp.17~25 (2016)
51. Yue, Y., "VIRMA mediates preferential m(6)A mRNA methylation in 3’UTR and near stop codon and associates with alternative polyadenylation", Cell Discov, 4, pp.10~ (2018)
52. Yue, B., "METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer", Mol. Cancer, 18, pp.142~ (2019)
53. Ma, H., "m6A methyltransferase Wilms’ tumor 1-associated protein facilitates cell proliferation and cisplatin resistance in NK", T cell lymphoma by regulating dual-specificity phosphatases 6 expression via m6A RNA methylation, 2021, pp.73, 108~117
54. Zou, S., "N-6-Methyladenosine : a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5", Sci. Rep, 6, pp.25677~ (2016)
55. Wang, X., "N(6)-methyladenosine modulates messenger RNA translation efficiency", Cell, 161, pp.1388~1399 (2015)
56. Wang, X., "N6-methyladenosine-dependent regulation of messenger RNA stability", Nature, 505, pp.117~120 (2014)
57. Shi, H., "YTHDF3 facilitates translation and decay of N(6)-methyladenosinemodified RNA", Cell Res, 27, pp.315~328 (2017)
58. Lasman, L., "Context-dependent functional compensation between Ythdf m(6)A reader proteins", Gene Dev, 34, pp.1373~1391 (2020)
59. Zaccara, S., "A Unified model for the function of YTHDF proteins in regulating m(6)A-modified mRNA", Cell, 181, pp.1582~1595 (2020)
60. Huang, H., "Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation", Nat. Cell Biol, 20, pp.285~295 (2018)
61. Bell, J. L., "Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): posttranscriptional drivers of cancer progression?", Cell. Mol. Life Sci, 70, pp.2657~2675 (2013)
62. Ying, Y., "EGR2-mediated regulation of m6A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization", Cell Death Dis, 12, pp.750~ (2021)
63. Wallis, N., "Small molecule inhibitor of Igf2bp1 represses Kras and a prooncogenic phenotype in cancer cells", RNA Biol, 19, pp.26~43 (2022)
64. Panneerdoss, S., "Cross-talk among writers, readers, and erasers of m(6)A regulates cancer growth and progression", Sci. Adv, 4, pp.eaar8263~ (2018)
65. Cheng, M., "The m(6)A methyltransferase METTL3 promotes bladder cancer progression via AFF4", NF-kappaB, Oncogene, pp.2019, 38[DOI]
66. Ling, Z., "m6A-dependent up-regulation of DRG1 by METTL3and ELAVL1 promotes growth, migration, and colony formation in osteosarcoma", Biosci. Rep, 40, pp.BSR2020028~ (2020)
67. Lin, X., "RNA m(6)A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail", Nat. Commun, 10, pp.2065~ (2019)
68. Zhang, C., "Reduced m6A modification predicts malignant phenotypes and augmented Wnt", PI3K-Akt signaling in gastric cancer, 2019, pp.8, 4766~4781
69. Yin, H., "RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming", Nat. Commun, 12, pp.1394~ (2021)
70. Yang, G., "Insulin-like growth factor 2 enhances regulatory T-cell functions and suppresses food allergy in an experimental model", J. Allergy Clin. Immunol, 133, pp.1702~1708 (2014)
71. Zhang, Y., "Dynamic expression of m(6)A regulators during multiple human tissue development and cancers", Front. Cell Dev. Biol, 8, pp.629030~ (2020)

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