의약물질의 환경오염과 환경보건
Pharmaceuticals in Environment and Their Implication in Environmental Health
2
조회
0
다운로드
8
인용
0
참고문헌
키워드
초록
Pharmaceuticals in the aquatic environment are trace contaminants of growing importance in environmental health due to their physiologically active nature. Pharmaceuticals could affect non-target species and might eventually damage sustainability of susceptible populations in the ecosystem. Potentials for health consequences among susceptible human population cannot be ruled out since long-term exposure to cocktails of pharmaceuticals, which might be present in drinking water, is possible. Selection of antibiotic resistant microorganisms is of another concern. In order to understand, and if needed, to properly address the environmental health issues of pharmaceutical residues, knowledge gaps need to be filled. Knowledge gaps exist in many important areas such as prioritization of target pharmaceuticals for further risk studies, occurrence patterns in different environments, chronic toxicities, and toxicities of pharmaceutical mixtures. Appropriate treatment technologies for drinking water and wastewater could be developed when they are deemed necessary. One of the simplest, yet most efficient measures that could be undertaken is to implement a return program for unused or expired drugs. In addition, implementation of environmental risk assessment frameworks for pharmaceuticals would make it possible to efficiently
Abstract
Pharmaceuticals in the aquatic environment are trace contaminants of growing importance in environmental health due to their physiologically active nature. Pharmaceuticals could affect non-target species and might eventually damage sustainability of susceptible populations in the ecosystem. Potentials for health consequences among susceptible human population cannot be ruled out since long-term exposure to cocktails of pharmaceuticals, which might be present in drinking water, is possible. Selection of antibiotic resistant microorganisms is of another concern. In order to understand, and if needed, to properly address the environmental health issues of pharmaceutical residues, knowledge gaps need to be filled. Knowledge gaps exist in many important areas such as prioritization of target pharmaceuticals for further risk studies, occurrence patterns in different environments, chronic toxicities, and toxicities of pharmaceutical mixtures. Appropriate treatment technologies for drinking water and wastewater could be developed when they are deemed necessary. One of the simplest, yet most efficient measures that could be undertaken is to implement a return program for unused or expired drugs. In addition, implementation of environmental risk assessment frameworks for pharmaceuticals would make it possible to efficiently
참고문헌 (52)
- Kolpin, D. W., "Pharmaceuticals, hormones, and other wastewater contaminants in U.S. streams, 1999-2000: A national reconnaissance", Environmental Science and Technology, 36(6), pp.1202~1211 (2002)
- Barceló, D, "Pharmaceutical-residue analysis", Trends in Analytical Chemistry, 26(6), pp.454~455 (2007)
- Jjemba, P, "Excretion and ecotoxicity of pharmaceutical and personal care products in the environment", Ecotoxicology and Environmental Safety, 63(1), pp.113~130 (2006)
- Kim, Y. H., "Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea", Environment International, 33(3), pp.370~375 (2007)
- Environmental Risk Assessment of Pharmaceutical: Model Application for Estimating Pharmaceutical Exposures in the Han River Basin, "Park, J", Korea Environment Institute, ~, pp.KEI 2007 RE-06 (2007)
- Kümmerer, K, "The presence of pharmaceuticals in the environment due to human use- present knowledge and future challenges", Journal of Environmental Management, 90(8), pp.2354~2366 (2009)
- Focazio, M. J, "A national reconnaissance for pharmaceuticals and other organic wastewater contaminants in the United States- II) untreated drinking water sources", The Science of the Total Environment, 40(2)통권 : 2, pp.201~216 (2008)
- Bound, J. P, "Household disposal of pharmaceuticals as a pathway for aquatic contamination in the United Kingdom", Environmental Health Perspectives, 112(12), pp.1702~1711 (2005)
- Persson, M, "Handling of unused prescription drugs- knowledge, behavior and attitude among Swedish people", Environment International, 35(5), pp.771~774 (2009)
- Kang, Y. H, "Developing Management Policy on Unused", expired Pharmaceuticals. Seoul National University, Master of Public Health, 2006
- Kim, Y. H, "Prioritizing veterinary pharmaceuticals for aquatic environment in Korea", Environmental Toxicology and Pharmacology, 26(2), pp.167~176 (2008)
- Park, J, "Environmental risk management of pharmaceuticals. in: New Challenges and Directions of Environmental Policy", pp.247~268 (2008), Korea Environment Institute
- Fent, K, "Ecotoxicology of human pharmaceuticals", Aquatic Toxicology, 76(2), pp.122~159 (2006)
- Harries, J. E, "Estrogenic activity in five United Kingdom rivers detected by measurement of vitellogenesis in caged male trout", Environmental Toxicology and Chemistry, 16(3), pp.534~542 (1997)
- Jobling, S, "Ecotoxicology of human pharmaceuticals", Environmental Science and Technology, 32(17), pp.2498~2506 (1998)
- Desbrow, C, "Identification of estrogenic chemicals in STW effluent 1. Chemical fractionation and in vitro biological screening", Environmental Science and Technology, 32(11), pp.1549~1558 (1998)
- Folmar, L. C, "Altered serum sex steroids and vitellogenin induction in walleye (Stizostedion vitreum) collected near a metropolitan sewage treatment plant", Archives of Environmental Contamination and Toxicology, 40(3), pp.392~398 (2001)
- Kidd, K. A, "Collapse of a fish population after exposure to a synthetic estrogen", Proceedings of National Academy of Science of the USA, 104(21), pp.8897~8901 (2007)
- Oaks, J. L, "Diclofenac residues as the cause of vulture population decline in Pakistan", Nature, 427(6975), pp.630~603 (2004)
- Proffitt, F, "Ecology. Circling in on a vulture killer", Science, 306(5694), pp.223~ (2004)
- Naidoo, V, "Veterinary diclofenac threatens Africa's endangered vulture species", Regulatory Toxicology and Pharmacology, 53, pp.205~208 (2009)
- Kim, S, "Potential ecological and human health impacts of antibiotics and antibiotic-resistant bacteria from wastewater treatment plants", Journal of Toxicology and Environmental Health Part B, 10(8), pp.559~573 (2007)
- Chung, Y. H, "Occurrence of antimicrobial resistant microbes in Korean environment", 2008 Annual Conference of Korean Society of Environmental Agriculture, pp.35~40 (2008)
- Ohlsen, K, "Impact of antibiotics on conjugational resistance gene transfer in Staphylococcus aureus in sewage", Environmental Microbiology, 5(8), pp.711~716 (2003)
- Kümmerer, K, "Promoting resistance by the emission of antibiotics from hospitals and households into effluent", Clinical Microbiology and Infection, 9(12), pp.1203~1214 (2003)
- Brandt, K. K, "Increased pollutioninduced bacterial community tolerance to sulfadiazine in soil hotspots amended with artificial root exudates", Environmental Science and Technology, 43(8), pp.2963~2968 (2009)
- Cattoir, V, "Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental Aeromonas spp", Emerging Infectious Diseases, 14(2), pp.231~237 (2008)
- Sapkota, A. R, "Antibiotic-resistant enterococci and fecal indicators in surface water and groundwater impacted by a concentrated Swine feeding operation", Environmental Health Perspectives, 115(7), pp.1040~1045 (2007)
- Yang, H, "Occurrence of ceftriaxone-resistant commensal bacteria on a dairy farm and a poultry farm", Canadian Journal of Microbiology, 52(10), pp.942~950 (2006)
- Martinez, J. L, "Environmental pollution by antibiotics and by antibiotic resistance determinants", Environmental Pollution, 157(11), pp.2893~2902 (2009)
- Webb, S, "Indirect human exposure to pharmaceuticqals via drinking water", Toxicology Letters, 142(3), pp.157~167 (2003)
- Schwab, B. W, "Human pharmaceuticals in US surface waters: A human health risk assessment", Regulatory Toxicology and Pharmacology, 42(3), pp.296~312 (2005)
- Cunningham, V. L, "Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment", Regulatory Toxicology and Pharmacology, 53(1), pp.39~45 (2009)
- Human Exposure Assessment for Antibiotics in the Water Environment, "Food and Drug Administration", Seoul National University, ~ (2007)
- Pharmaceutical residues in Han River and their impact on freshwater ecosystem, "Kim, P. G", Korea Research Foundation, ~ (2005)
- Contamination of major veterinary antibiotics and antimicrobials in upstream Han River, and human health and ecological risk assessment, "Kim, P. G", Korea Research Foundation, ~ (2006)
- Han, G. H, "Ecotoxicological risk of pharmaceuticals from wastewater treatment plants in Korea: occurrence and toxicity to Daphnia magna", Environmental Toxicology and Chemistry, 25(1), pp.265~271 (2006)
- Choi, K, "Occurrences and ecological risks of roxithromycin, trimethoprim, and chloramphenicol in Han River, Korea", Environmental Toxicology and Chemistry, 27(3), pp.711~719 (2008)
- Development of analytical method and study of exposure of pharmaceuticals and personal care products in environment, "National Institute of Environmental Research", Kyonggi University, ~ (2006)
- Development of analytical method and study of exposure of pharmaceuticals and personal care products in environment (II), "National Institute of Environmental Research", Kyonggi University, ~ (2007)
- Development of analytical method and study of exposure of pharmaceuticals and personal care products in environment (III), "National Institute of Environmental Research", Yongin University, ~ (2008)
- Kim, S. D, "Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters", Water Research, 41(5), pp.1013~1021 (2007)
- Choi, K, "Seasonal variations of several pharmaceutical residues in surface water and sewage treatment plants of Han River, Korea", Science of the Total Environment, 405(1), pp.120~128 (2008)
- An Approach for Developing Aquatic Environmental Risk Assessment Framework for Pharmaceuticals in Korea, "Park, J", Korea Environment Institute, ~, pp.KEI 2006 RE-05 (2006)
- Oh, S. J, "Ecological hazard assessment of major veterinary benzimidazoles: acute and chronic toxicities to aquatic microbes and invertebrates", Environmental Toxicology and Chemistry, 25(8), pp.2221~2226 (2006)
- Calabrese, E. J, "Toxicology rethinks its central belief. Hormesis demands a reappraisal of the way risks are assessed", Nature, 421(6924), pp.691~692 (2003)
- Development document for final effluent limitations guidelines and standards for the pharmaceutical manufacturing point source category, "US Environmental Protection Agency", Office of Water, ~, pp.EPA-921-R-98-005 (1998)
- "EMEA", CHMP-European Medicines Evaluation Agency, CHMP, pp.SWP, 4447[DOI]
- Guidance for Industry; Environmental Assessment for Human Drug and Biologics Applications, "US Food and Drug Administration", ~ (1998)
- "Directive 2001", 83, Official Journal, pp.2001, 311[DOI]
- Meisel, M. L, "Regulatory approach on environmental risk assessment. Risk management recommendations, reasonable and prudent alternatives", Ecotoxicology, 18(8), pp.1176~1181 (2009)
- "Directive 2001", 82, Official Journal, pp.2001, 311[DOI]
