소아 보카바이러스 호흡기 감염증의 역학적 특징
Epidemiologic Characteristics of Human Bocavirus-Associated Respiratory Infection in Children
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목 적:본 연구는 소아에서 보카바이러스와 연관된 하기도 감염증의 역학적인 특성에 대해 알아보고자 하였다. 방 법:2000년 3월부터 2005년 9월까지 서울대학교병원과 분당 서울대학교병원에 하기도 감염증으로 입원한 658명의 소아에게서 비인두 흡입 검체를 채취하였다. 다중 역전사 중합효소 연쇄 반응을 이용하여 11종의 바이러스를 조사하였고, 의무기록을 후향적으로 분석하였다. 결 과:전체 호흡기바이러스는 658명의 환아 중 325명(49.4%)에서 검출되었다. 보카바이러스는 62명(9.4 %)에서 검출되었으며, 3개월 이상 5세 미만에서 많았다. 보카바이러스가 중복감염이 확인된 것은 37.1%로, 전체 바이러스 양성 환자들의 중복감염률(12.3%)보다 의미 있게 높은 것으로 확인되었다(P=0.000). 또한 늦은 봄부터 이른 여름인 5월부터 7월에 많이 검출되었다. 결 론:보카바이러스는 국내에서 소아의 하기도 감염증에서 유병률이 높았고, 특히 늦은 봄부터 초여름에 유행하였다.
Abstract
Purpose:This study was performed to investigate the epidemiologic characteristics of human bocavirus (HBoV)-associated lower respiratory tract infections (LRTIs) in children. Methods:Nasopharyngeal aspirate samples were obtained from 658 children who had been hospitalized for LRTIs in Seoul National University (SNU) Children’s Hospital and SNU Bundang Hospital from March 2000 to September 2005. Multiplex RT-PCR was performed to detect 11 respiratory viruses including respiratory syncytial virus, adenovirus, rhinovirus, parainfluenza viruses 1 and 3, influenza viruses A and B, human metapneumovirus, HBoV, human coronavirus (HCoV) OC43/ 229E, and HCoV-NL63. Clinical data were reviewed retrospectively. Results:Overall, respiratory viruses were detected in 325 (49.4%) among 658 patients. HBoV was detected in 62 cases (9.4%) and was responsible for 19.1% of virus-positive cases. HBoV was prevalent among infants and young children aged from 3 months to 5 years with the mean age of 25.3 months. Co-detection of HBoV and other respiratory viruses was observed in 37.1% which is significantly higher than average co-detection rate (12.3%) among overall virus-positive cases (P=0.000). HBoV was identified mainly in late spring and early summer from May to July. Conclusion:This study describes epidemiologic features of HBoV in Korean children compared with those associated with other respiratory viruses. HBoV was prevalent among LRTIs in childhood, especially in late spring and early summer season in Korea.
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