한국인에서 뎅기바이러스 항체의 혈청 유병률 연구
Seroprevalence of Dengue Virus Antibody in Korea
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목적: 뎅기바이러스 감염 환자 발생은 해외 여행이 증가함에 따라 증가하고 있다. 최근 감염 경험이 없는 사람에게 백신을 접종하면 이후 야생 뎅기바이러스 감염 시 중증 뎅기열 증상을 보일 수 있다고 연구된 바 있다. 따라서, 본 연구는 한국의 다양한 연령군에서 뎅기바이러스에 대한 혈청역학을 연구하였다. 방법: 건강한 영아 98명(2개월–1세), 청소년 152명(13–19세), 성인 90명(20–50세) 및 노인 106명(65세 이상)에서 수집한 혈청 총 446명을 대상으로 하였다. 각 연령군의 뎅기바이러스 immunoglobulin G (IgG) 항체 검사를 ELISA을 통해 측정하였다. 또한 뎅기바이러스 IgG 항체 검사에서 양성 또는 equivocal을 보이는 혈청에 한하여 일본뇌염 바이러스의 IgG 항체를 검사하였다. 결과: 총 446명 검체 중, 청소년군에서 1명(0.2%)만 뎅기바이러스 항체 검사에서 양성으로 나왔다. Equivocal은 14명(3.1%) 으로, 청소년군 10명과 노인군 4명이 해당하였다. 뎅기바이러스 IgG 양성이 나온 1명에서 일본뇌염 바이러스 또한 IgG 양성으로 나왔다. 뎅기바이러스 IgG equivocal이 나온 14명에서는 일본뇌염 바이러스 IgG 양성이 6명, equivocal이 3 명이었고 음성은 5명이었다. 결론: 한국인에서 뎅기바이러스에 대한 항체 보유율은 매우 낮았다. 본 연구는 향후 뎅기열 예방을 위한 보건 정책 수립에 중요한 자료가 될 수 있을 것이며 향후 지속적인 혈청면역 평가도 필요할 것이다.
Abstract
Purpose: The number of dengue fever cases is rising due to increasing overseas travel. Vaccination makes severe dengue fever in seronegative individuals after vaccination when they exposure to wild-type dengue virus. We investigated the seroepidemiology of the dengue virus for monitoring of Korean dengue virus immunity and establishing the prevention of dengue infection. Methods: The study was based on 446 residual sera collected from 98 infants (2 months to 1 year old), 152 adolescents (13 to 19 years old), 90 adults (20 to 50 years old), and 106 elderly participants (more than 65 years old) for other studies. Antibody levels for dengue virus immunoglobulin G (IgG) in each age group were measured using an enzyme-linked immunosorbent assay (ELISA). For each dengue virus IgG positive or equivocal result, an IgG ELISA was performed for Japanese encephalitis virus. Results: Of the 446 serum samples, only 1 (0.2%) adolescent had a positive result from the dengue IgG antibody test. In the dengue virus IgG antibody test, 14 (3.1%) samples showed equivocal results (10 adolescents and 4 elderly). In the 1 positive case of dengue virus IgG, the Japanese encephalitis IgG test was also positive. In the 14 equivocal cases of dengue virus IgG, there were 6 positive, 3 equivocal, and 5 negative of Japanese encephalitis IgG. Conclusions: The seroprevalence rate of dengue virus was very low in Koreans. This study provides important data for establishing the policy for preventive measures of dengue fever. It will be necessary to continuously monitor for dengue virus immunity.
참고문헌 (28)
- Nimmannitya S, "Clinical spectrum and management of dengue haemorrhagic fever", Southeast Asian J Trop Med Public Health, 18, pp.392~397 (1987)
- L'Azou M, "Symptomatic dengue in children in 10 Asian and Latin American countries", N Engl J Med, 374, pp.1155~1166 (2016)
- Hales S, "Potential effect of population and climate changes on global distribution of dengue fever: an empirical model", Lancet, 360, pp.830~834 (2002)
- Lee SH, "The effects of climate change and globalization on mosquito vectors: evidence from Jeju Island, South Korea on the potential for Asian tiger mosquito (Aedes albopictus) influxes and survival from Vietnam rather than Japan", PLoS One, 8, pp.e68512~ (2013)
- "Dengue and Severe Dengue" (2018)[URL]
- Hadinegoro SR, "Efficacy and long-term safety of a Dengue vaccine in regions of endemic disease", N Engl J Med, 373, pp.1195~1206 (2015)
- Flasche S, "The long-term safety, public health impact, and cost-effectiveness of routine vaccination with a recombinant, live-attenuated dengue vaccine (Dengvaxia): a model comparison study", PLoS Med, 13, pp.e1002181~ (2016)
- Koh BK, "2005 dengue epidemic in Singapore: epidemiology, prevention and control", Ann Acad Med Singapore, 37, pp.538~545 (2008)
- Ooi EE, "Dengue seroepidemiology in Singapore", Lancet, 357, pp.685~686 (2001)
- Yew YW, "Seroepidemiology of dengue virus infection among adults in Singapore", Ann Acad Med Singapore, 38, pp.667~675 (2009)
- Raj AS, "A study on clinical presentation of dengue fever in children", IJSR, 5, pp.2272~2275 (2016)
- Ukey P, "Study of seroprevalence of dengue fever in central India", Indian J Community Med, 35, pp.517~519 (2010)
- Jamjoom GA, "Seroepidemiology of asymptomatic Dengue virus infection in Jeddah, Saudi Arabia", irology (Auckl), 7, pp.1~7 (2016)
- Jeong YE, "Identification of dengue type 1 virus (DENV-1) in Koreans traveling abroad", Osong Public Health Res Perspect, 2, pp.34~40 (2011)
- "Guidelines for Viral Mosquito-born Diseases Prevention and Control" (2017)[URL]
- Kim H, "A case of imported dengue hemorrhagic fever", Korean J Infect Dis, 27, pp.6~ (1995)
- Park JH, "Dengue fever in South Korea, 2006–2010", Emerg Infect Dis, 18, pp.1525~1527 (2012)
- "Disease Web Statistics System" (2018)[URL]
- "Information on Tourist Statistics" (2017)[URL]
- Cobelens FG, "Incidence and risk factors of probable dengue virus infection among Dutch travellers to Asia", Trop Med Int Health, 7, pp.331~338 (2002)
- Wilder-Smith A, "Dengue in travelers", N Engl J Med, 353, pp.924~932 (2005)
- 김동현, "일본뇌염 예방접종 후 면역원성 및 중화항체 지속률에 관한 조사:전향적 다기관 코호트 연구", Pediatric Infection and Vaccine, 20(3), pp.131~138 (2013), 대한소아감염학회
- Lee EJ, "Prevalence of neutralizing antibodies to Japanese Encephalitis virus among high-risk age groups in South Korea, 2010", PLoS One, 11, pp.e0147841~ (2010)
- Thai KT, "Incidence of primary dengue virus infections in Southern Vietnamese children and reactivity against other flaviviruses", Trop Med Int Health, 12, pp.1553~1557 (2007)
- Kliks SC, "Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever", Am J Trop Med Hyg, 40, pp.444~451 (1989)
- Sridhar S, "Effect of dengue serostatus on dengue vaccine safety and efficacy", N Engl J Med, 379, pp.327~340 (2018)
- 차고윤, "Comparison of Four Serological Tests for Detecting Antibodies to Japanese Encephalitis Virus after Vaccination in Children", Osong Public Health and Research Perspectives, 5(5), pp.286~291 (2014), 질병관리청
- Marrero-Santos KM, "Optimization of the cutoff value for a commercial anti-dengue virus IgG immunoassay", Clin Vaccine Immunol, 20, pp.358~362 (2013)