급성위장관염 소아에서 원인체의 분석과 임상증상의 중증도에 대한 연구
Comparing the Cause and Symptom Severity of Children with Acute Gastroenteritis
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Purpose : Acute gastroenteritis is a frequent childhood disease. The purpose of this study is to determine if certain pathogens are related to more severe clinical disease in children with acute gastroenteritis. Methods : Two hundred seventy one stool samples were obtained from pediatric patients with acute gastroenteritis that was associated with virus, bacteria and protozoa infection between January 2006 and December 2006. The clinical severity was assessed by using the 24 point scale Clark score. We evaluate the Clark score according to the pathogens. Results : One hundred thirty seven children were noted to have virus, bacteria or protozoal infection. Rotavirus was the most common pathogen found in the children with gastroenteritis (20.6%). Other frequent pathogens were norovirus (10.7%) and E. coli (12.9%). Vomiting (P=0.049) and diarrhea (P=0.003) symptoms were more frequent in the rotavirus group than that in the rotavirus negative group. There were no statistical differences in the Clark score between the virus positive group and the virus negative group. Conclusion : We concluded that rotavirus was the most common pathogen in children with gastroenteritis, yet the clinical severity was not dependent on the presence of viral or bacterial pathogens. (Korean J Pediatr Infect Dis 2008;15:138-145)
Abstract
Purpose : Acute gastroenteritis is a frequent childhood disease. The purpose of this study is to determine if certain pathogens are related to more severe clinical disease in children with acute gastroenteritis. Methods : Two hundred seventy one stool samples were obtained from pediatric patients with acute gastroenteritis that was associated with virus, bacteria and protozoa infection between January 2006 and December 2006. The clinical severity was assessed by using the 24 point scale Clark score. We evaluate the Clark score according to the pathogens. Results : One hundred thirty seven children were noted to have virus, bacteria or protozoal infection. Rotavirus was the most common pathogen found in the children with gastroenteritis (20.6%). Other frequent pathogens were norovirus (10.7%) and E. coli (12.9%). Vomiting (P=0.049) and diarrhea (P=0.003) symptoms were more frequent in the rotavirus group than that in the rotavirus negative group. There were no statistical differences in the Clark score between the virus positive group and the virus negative group. Conclusion : We concluded that rotavirus was the most common pathogen in children with gastroenteritis, yet the clinical severity was not dependent on the presence of viral or bacterial pathogens. (Korean J Pediatr Infect Dis 2008;15:138-145)
참고문헌 (21)
- Cohen MB, "Etiology and mechanisms of acute infectious diarrhea in infants in the United States", J Pediatr, pp.34~39 (1991)
- Korea Center for Diseases Control and Prevention, "Laboratory surveillance on acute gastroenteritis", Commun Dis Rep, 18, pp.2~9 (2007)
- 마상혁, "소아의 급성 감염성 설사", Korean Journal of Pediatrics, 48(3), pp.235~250 (2005), 대한소아과학회
- Givon-Lavi N, "Comparison between two severity scoring scales commonly used in the evaluation of rotavirus gastroenteritis in children", Vaccine, 26, pp.5798~5801 (2008)
- Ellen SB, "Rotavirus", Pediatr Rev, 28, pp.183~190 (2007)
- Kim JS, "Epidemiologic profile of rotavirus infection in the Republic of Korea: Results from prospective surveillance in the Jeongeub District, 1 July 2002 through 30 June 2004", J Infect Dis, 192, pp.49~56 (2005)
- Song MO, "Distribution of human group a rotavirus VP7 and VP4 types circulating in Seoul, Korea between 1998 and 2000", J Med Virol, 70, pp.324~328 (2003)
- in Seoul, South Korea, "J Med Virol", 2008, 1661~1665
- Albano F, "Rotavirus and not age determines gastroenteritis severity in children: a hospital-based study", Eur J Pediatr, 166, pp.241~247 (2007)
- Colomba C, "Viral gastroenteritis in children hospitalised in Sicily, Italy", Eur J Clin Microbiol Infect Dis, 25, pp.570~575 (2006)
- Nakagomi T, "Incidence and burden of rotavirus gastroenteritis in Japan, as estimated from a prospective sentinel hospital study", J Infect Dis, 192, pp.106~110 (2005)
- Chung JK, "Epidemiological study of viral diarrhea in Gwangju Area during 2000-2002", J Bateriol and Virol, 36, pp.195~203 (2006)
- Colomba C, "Norovirus and gastroenteritis in hospitalized children, Italy", Emerg Infect Dis, 13, pp.1389~1391 (2007)
- Banerjee I, "Comparative study of the epidemiology of rotavirus in children from a community-based birth cohort and a hospital in South India", J Clin Microbiol, 44, pp.2468~2474 (2006)
- Medici MC, "Molecular epidemiology of norovirus infection in sporadic cases of viral gastroenteritis among children in Northern Italy", J Med Virol, 78, pp.1486~1492 (2006)
- Mustafa H, "Epidemiology of astrovirus infection in young children hospitalized with acute gastroenteritis in Melbourne, Australia, over a period of four consecutive years, 1995 to 1998", J Clin Microbiol, 38, pp.1058~1062 (2000)
- Velazquez FR, "Rotavirus infections in infants as protection against susequent infections", N Engl J Med, 335, pp.1022~1028 (1996)
- Franco MA, "Immunity and correlates of protection for rotavirus vaccines", Vaccine, 24, pp.2718~2731 (2006)
- 오성희, "설사 환자에서의 항생제 요법", 소아감염, 9(1), pp.19~26 (2002), 한국소아감염병학회
- 김은주, "The Effectiveness of Antibiotics in Acute Diarrhea of Children", 소아감염, 6(2), pp.203~209 (1999), 한국소아감염병학회
- 이수영, "식품 알레르기", Korean Journal of Pediatrics, 47(3), pp.240~246 (2004), 대한소아과학회