Prognostic Factors of Neonatal Sepsis Mortality in Developing Country
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Purpose: Sepsis is the most common cause of neonatal death accounting for 30–50% of mortality annually in developing countries. This study was to determine the prognostic factors of neonatal sepsis mortality. Methods: A retrospective cohort was conducted in Dr. R. Sosodoro Djatikoesoemo Governor Hospital from April 2021 to September 2021 on 121 neonates in the neonatal intensive care unit (NICU) diagnosed with sepsis. The inclusion criteria were neonates aged 0–28 days, admitted to the NICU, and diagnosed with sepsis. The exclusion criteria were incomplete data and the presence of congenital abnormalities. A χ2 test was performed on the sex, gestational age, mode of delivery, birth weight, APGAR score, birthplace, and blood culture. A normality test was performed on leukocytes, lymphocytes, neutrophils, platelets, C-reactive protein (CRP), and length of stay. Then performed a Mann-Whitney test. Results: Birth weight (P=0.038), gestational age (P=0.009), and blood culture (P=0.014) showed a significant relationship with the neonatal sepsis outcome while Mann-Whitney test showed significant differences in the platelets (P=0.018), CRP (P=0.002), and length of stay (P<0.001). Multivariate analysis showed that 3 prognostic factors associated with neonatal sepsis mortality were prematurity (odds ratio [OR], 3.906; 95% confidence interval [CI], 1.344–11.356; P=0.012), low birth weight (LBW, OR, 2.833; 95% CI, 1.030–7.790; P=0.044), and gram-negative bacteria (OR, 4.821; 95% CI, 1.018–22.842; P=0.047). Conclusions: Prematurity, LBW, and gram-negative bacteria were associated with the prognostic factors of neonatal sepsis.
Abstract
Purpose: Sepsis is the most common cause of neonatal death accounting for 30–50% of mortality annually in developing countries. This study was to determine the prognostic factors of neonatal sepsis mortality. Methods: A retrospective cohort was conducted in Dr. R. Sosodoro Djatikoesoemo Governor Hospital from April 2021 to September 2021 on 121 neonates in the neonatal intensive care unit (NICU) diagnosed with sepsis. The inclusion criteria were neonates aged 0–28 days, admitted to the NICU, and diagnosed with sepsis. The exclusion criteria were incomplete data and the presence of congenital abnormalities. A χ2 test was performed on the sex, gestational age, mode of delivery, birth weight, APGAR score, birthplace, and blood culture. A normality test was performed on leukocytes, lymphocytes, neutrophils, platelets, C-reactive protein (CRP), and length of stay. Then performed a Mann-Whitney test. Results: Birth weight (P=0.038), gestational age (P=0.009), and blood culture (P=0.014) showed a significant relationship with the neonatal sepsis outcome while Mann-Whitney test showed significant differences in the platelets (P=0.018), CRP (P=0.002), and length of stay (P<0.001). Multivariate analysis showed that 3 prognostic factors associated with neonatal sepsis mortality were prematurity (odds ratio [OR], 3.906; 95% confidence interval [CI], 1.344–11.356; P=0.012), low birth weight (LBW, OR, 2.833; 95% CI, 1.030–7.790; P=0.044), and gram-negative bacteria (OR, 4.821; 95% CI, 1.018–22.842; P=0.047). Conclusions: Prematurity, LBW, and gram-negative bacteria were associated with the prognostic factors of neonatal sepsis.
참고문헌 (20)
- Global report on the epidemiology and burden of sepsis: current evidence, identifying gaps and future directions, "World Health Organization", World Health Organization, ~ (2020)
- Fleischmann C, "Global incidence and mortality of neonatal sepsis : a systematic review and meta-analysis", Arch Dis Child, 106, pp.745~752 (2021)
- Aijaz N, "Disease burden of NICU, at a tertiary care hospital, Karachi", J Dow Univ Health Sci, 6, pp.32~35 (2012)
- "Proportion of deaths by region: sepsis and other infectious conditions of the newborn" (2015)[URL]
- Basic health research, "National Institute of Health Research and Development (ID)", National Institute of Health Research and Development, ~ (2010)
- Jumah DS, "Predictors of mortality outcome in neonatal sepsis", Med J Basrah Univ, 25, pp.11~18 (2007)
- Schmutz N, "Expected ranges for blood neutrophil concentrations of neonates : the Manroe and Mouzinho charts revisited", J Perinatol, 28, pp.275~281 (2008)
- Hadinegoro SR, "Consensus on diagnosis and management of sepsis in children" (2016), Publishing Agency of the Association of Pediatricians
- Putra PJ, "Incidence and factors associated with neonatal sepsis in Sanglah General Hospital, Denpasar", Sari Pediatr, 14, pp.205~210 (2016)
- Kardana IM, "Incidence and factors associated with mortality of neonatal sepsis", Paediatr Indones, 51, pp.144~148 (2011)
- Gudayu TW, "The role of the season at admission in neonatal sepsis : a retrospective chart review of a 1-year data at University of Gondar comprehensive specialized hospital", BMC Res Notes, 12, pp.643~ (2019)
- Meshram RM, "Predictors of mortality in outborns with neonatal sepsis : a prospective observational study", Niger Postgrad Med J, 26, pp.216~222 (2019)
- Trotman H, "Predictors of poor outcome in neonates with bacterial sepsis admitted to the University Hospital of the West Indies", West Indian Med J, 55, pp.80~84 (2006)
- Wu Y, "C-reactive protein and inflammation : conformational changes affect function", Biol Chem, 396, pp.1181~1197 (2015)
- Lobo SM, "C-reactive protein levels correlate with mortality and organ failure in critically ill patients", Chest, 123, pp.2043~2049 (2003)
- Kermorvant-Duchemin E, "Outcome and prognostic factors in neonates with septic shock", Pediatr Crit Care Med, 9, pp.186~191 (2008)
- Saleem AF, "Pan-resistant Acinetobacter infection in neonates in Karachi, Pakistan", J Infect Dev Ctries, 4, pp.30~37 (2009)
- Turhan EE, "Factors which affect mortality in neonatal sepsis", Turk Pediatri Ars, 50, pp.170~175 (2015)
- Ree IM, "Thrombocytopenia in neonatal sepsis : incidence, severity and risk factors", PLoS One, 12, pp.e0185581~ (2017)
- Faranita T, "Coagulation disorders in sepsis", Sari Pediatr, 13, pp.226~232 (2016)