본문 바로가기
KERD
논문KCI 등재

鎖陽의 期間別 投藥이 수컷 생쥐 生殖能力에 미치는 영향

Administration Duration Dependent Effects of Cynomorii Herba Extract Solution on the Reproductive Capacities in the Mice

이진무|장준복|이창훈|조정훈|이경섭|최은미
대한한방부인과학회 (The Society Of Oriental Obstetrics & Gynecology)|2007.02|대한한방부인과학회지 (The Journal of Oriental Obstetrics ＆ Gynecology)|제20권 제1호|pp. 17-32

2

조회

0

다운로드

3

인용

0

참고문헌

키워드

infertilitymiceCynomorii Herbaspermhyaluronidase activity
주제분류한의학

초록

Purpose: This study was undertaken to evaluate the effects of the different administration duration of Cynomorii Herba extract solution on the spermatogenic abilities such as concentration, motility and morphological normality of sperm from the testis and the activities of sperm hyaluronidase. Methods: We used the 8-week-old ICR mice and administered 0.3㎎/g extract solution of Cynomorii Herba once a day for 30, 60, 90 and 120 days. The control group was administered the normal saline in the same way and duration. We examined the number of total, motile and normal sperm from the cauda epididymis. And we compared the testicular tissue especially seminiferous tubules between control and treated groups by histochemical methods. At the end we observed the difference of sperm hyaluronidase activities between control and treated groups. Results: The significant differences were observed in the concentration of total sperm, the motility and normality of spermatozoa of the Cynomorii Herba extract solution administered groups compared to the control group in 60 and 90 days groups. In the histological analysis of the testicular tissues, the enlargement of testicular lobe diameter and apparent vasculogenesis between testicular lobes were observed in the Cynomorii Herba extract solution administered groups compared to the control group, respectively. Also, the activity of hyaluronidase was significantly increased in the Cynomorii Herba extract solution administered groups compared to the control group. Conclusion: This study shows that Cynomorii Herba has the beneficial effect on the concentration, morphology and motility of sperm especially in 60 and 90 days administration group. We can suggest that Cynomorii Herba extract solution be useful for the treatment of male sexual dysfunctions and infertility.

Abstract

Purpose: This study was undertaken to evaluate the effects of the different administration duration of Cynomorii Herba extract solution on the spermatogenic abilities such as concentration, motility and morphological normality of sperm from the testis and the activities of sperm hyaluronidase. Methods: We used the 8-week-old ICR mice and administered 0.3㎎/g extract solution of Cynomorii Herba once a day for 30, 60, 90 and 120 days. The control group was administered the normal saline in the same way and duration. We examined the number of total, motile and normal sperm from the cauda epididymis. And we compared the testicular tissue especially seminiferous tubules between control and treated groups by histochemical methods. At the end we observed the difference of sperm hyaluronidase activities between control and treated groups. Results: The significant differences were observed in the concentration of total sperm, the motility and normality of spermatozoa of the Cynomorii Herba extract solution administered groups compared to the control group in 60 and 90 days groups. In the histological analysis of the testicular tissues, the enlargement of testicular lobe diameter and apparent vasculogenesis between testicular lobes were observed in the Cynomorii Herba extract solution administered groups compared to the control group, respectively. Also, the activity of hyaluronidase was significantly increased in the Cynomorii Herba extract solution administered groups compared to the control group. Conclusion: This study shows that Cynomorii Herba has the beneficial effect on the concentration, morphology and motility of sperm especially in 60 and 90 days administration group. We can suggest that Cynomorii Herba extract solution be useful for the treatment of male sexual dysfunctions and infertility.

참고문헌 (37)

  1. "男性不妊症 治療에 관한 考察", pp.397~403 (1994)
  2. "EAU Guidelines on male infertility", 48(5), pp.703~711 (2005)
  3. "Semen quality and male reproductive health: the controversy about human sperm concentration decline", 109(5), pp.333~344 (2001)
  4. "Decline in semen quality among fertile men in Paris during the past 20 years", 332(5), pp.281~285 (1995)
  5. "Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility", 79, pp.1597~1605 (2003)
  6. "Evidence for decreasing quality of semen during past 50 years", pp.609~613 (1992)
  7. "남성불임의 약물치료", 47(12), pp.1223~1228 (2004)
  8. "男性不姙症의 治療에 對한 文獻的 考察", pp.151~162 (1994)
  9. "Effects of Cuscutae Semen on the reproductive competence of male mice", 16(1), pp.136~142 (2003)
  10. "鹿茸이 수컷생쥐의 生殖과 胚發生에 미치는 影響", 17(1), pp.129~137 (2004)
  11. "紫河車가 수컷생쥐의 生殖能力에 미치는 影響", 17(2), pp.1~10 (2004)
  12. "淫羊藿이 흰쥐 정자의 운동성에 미치는 영향", 17(2), pp.52~63 (2004)
  13. "濃度別 淫羊藿 投藥이 수컷 생쥐의 生殖能力에 미치는 影響", 18(1), pp.142~155 (2005)
  14. "淫羊藿의 수컷 생쥐 生殖能力에 대한 投藥期間別 效果", 19(3), pp.55~68 (2006)
  15. "子가 웅성 백서의 정소기능 및 catalase와 peroxidase의 활성에 미치는 영향", 17(3), pp.72~81 (2004)
  16. "濃度別 子 投藥이 수컷 생쥐의 生殖能力에 미치는 影響", 19(3), pp.41~54 (2006)
  17. "Effects of Morindae Officinalis Radix on the spermatogenesis and antioxidant activities in the SD rat", 26(4), pp.31~38 (2005)
  18. "濃度別 巴戟 投藥이 숫컷 생쥐의 生殖能力에 미치는 影響", 18(3), pp.17~31 (2005)
  19. "수컷생쥐 生殖能力에 대한 巴戟의 投藥期間別 效果", 27(3), pp.73~86 (2006)
  20. "Hydrogen Peroxide에 의해 유도된 남성생식세포의 세포독성에 미치는 鎖陽의 효과", 12(2), pp.155~162 (2004)
  21. "鎖陽이 白鼠 精子의 數 運動性 및 形成에 미치는 影響", 18(4), pp.24~35 (2005)
  22. "鎖陽의 濃度別 投藥이 수컷 생쥐 生殖能力에 미치는 影響", 19(2), pp.62~76 (2006)
  23. "남성불임의 진단과 치료", 46(9), pp.833~842 (2003)
  24. "In vitro fertilization outcome in the presence of severe male factor infertility", 63(5), pp.1032~1037 (1995)
  25. "남성불임의 유전적 요인 및 불임유전자 연구 현황", 16(6), pp.550~561 (2001)
  26. "원인불명의 남성불임 환자에서 pure follicle stimulating hormone과 human chorionic gonadotropin을 이용한 전신적 치료에 관한 연구", 39(7), pp.1310~1319 (1996)
  27. "남성의 불임에 영향을 미치는 제요인 분석", 15, pp.193~202 (2002)
  28. "Male Infertility: causes and cures", 3(2), pp.83~87 (2005)
  29. "남자불임증의 임상적 고찰", pp.221~229 (1980)
  30. "남성불임: 최근 10년간의 임상통계학적 분석", 37(8), pp.939~946 (1996)
  31. "정자감소로 인한 남성불임증의 최근 중의치료 동향에 대한 연구", 15(6), pp.637~644 (2001)
  32. "Male Infertility: nutritional and environmental considerations", 5(1), pp.28~38 (2000)
  33. "Withered Yang: a review of traditional chinese medical treatment of male infertility and erectile dysfunction", 22(2), pp.173~182 (2001)
  34. "Effects of acupuncture and moxa treatment in patients with semen abnormalities", 5(4), pp.345~348 (2003)
  35. "期間別 人蔘 投藥이 수컷 생쥐의 生殖能力에 미치는 影響", 19(2), pp.49~61 (2006)
  36. "체외수정시술시 예후인자로서 정자첨체반응 유발검사의 유용성", 25(3), pp.251~260 (1998)
  37. "부인과학(제3판)", pp.598~647 (1997), 서울:칼빈서적

관련 논문AI추천

鎖陽의 濃度別 投藥이 수컷 생쥐 生殖能力에 미치는 影響이경섭, 이창훈, 장준복, 조정훈, 한지영대한한방부인과학회 · 대한한방부인과학회지2006 · 제19권 제2호鎖陽이 白鼠 精子의 數, 運動性 및 形成에 미치는 影響이경섭, 장준복, 정선형, 조정훈대한한방부인과학회 · 대한한방부인과학회지2005 · 제18권 제4호Administration Term-dependent Effects of Allii Tuberosi Semen Extract Solution on the Reproductive Capacities in the Mice박대순, 이경섭, 이진무, 이창훈, 장준복, 조정훈대한한방부인과학회 · 대한한방부인과학회지2007 · 제20권 제2호淫羊藿의 수컷 생쥐 生殖能力에 대한 投藥期間別 效果이경섭, 이창훈, 장준복, 조정훈, 최정은대한한방부인과학회 · 대한한방부인과학회지2006 · 제19권 제3호濃度別 淫羊藿 投藥이 수컷 생쥐의 生殖能力에 미치는 影響이경섭, 이창훈, 장준복, 조정훈대한한방부인과학회 · 대한한방부인과학회지2005 · 제18권 제1호期間別 人蔘 投藥이 수컷 생쥐의 生殖能力에 미치는 影響김혜원, 이경섭, 장준복, 조정훈대한한방부인과학회 · 대한한방부인과학회지2006 · 제19권 제2호

이 간행물의 다른 논문 (17건)

利水？濕藥의 膣內 微生物에 대한 抗菌效果김은숙, 장준복, 이창훈, 조정훈, 이진무, 이경섭pp. 1-16益氣養榮湯의 항산화 및 유방암 세포주 생장 억제 효과에 미치는 영향이진아, 박경미, 조성희pp. 33-46橘葉散變方이 유방암 세포주 MCF-7 생장 억제에 미치는 영향조수인, 조성희, 양승정, 조현정pp. 47-60膈下逐瘀湯이 실험적으로 유발된 흰쥐의 자궁내막증에 미치는 영향김형준, 서일복, 이동녕, 김철수pp. 61-76腎氣丸合蒼附導痰湯이 Estradiol Valerate로 유도된 흰쥐의 다낭성 난소에 미치는 영향서일복, 유영기, 이동녕, 김형준pp. 77-92
원문 보기