Relationships between Cerebral Blood Flow and IQ in Typically Developing Children and Adolescents
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
The objective of this study was to explore the relationships between IQ and cerebral blood flow (CBF) measured by arterial spin labeling (ASL) in children and adolescents. ASL was used to collect perfusion MRI data on 39 healthy participants aged 7 to 17. The Wechsler Abbreviated Intelligence Scale was administered to determine IQ scores. Multi-variate regression was applied to reveal correlations between CBF and IQ scores, accounting for age, sex and global mean CBF. Voxel Based Morphometry (VBM) analysis, which measures regional cortical volume, was performed as a control. Regression analyses were further performed on CBF data with adjustment of regional gray matter density (GMD). A positive correlation between CBF and IQ scores was primarily seen in the subgenual/anterior cingulate, right orbitofrontal, superior temporal and right inferior parietal regions. An inverse relationship between CBF and IQ was mainly observed in bilateral posterior temporal regions. After adjusting for regional GMD, the correlatons between CBF and IQ in the subgenual/anterior cingulate cortex, right orbitofrontal, superior temporal regions and left insula remained significant. These findings support the Parieto-Frontal Integration Theory of intelligence, especially the role of the subgenual/anterior cingulate cortex in the neural networks associated with intelligence. The present study also demonstrates the unique value of CBF in assessing brain-behavior relationships, in addition to structural morphometric measures.
Abstract
The objective of this study was to explore the relationships between IQ and cerebral blood flow (CBF) measured by arterial spin labeling (ASL) in children and adolescents. ASL was used to collect perfusion MRI data on 39 healthy participants aged 7 to 17. The Wechsler Abbreviated Intelligence Scale was administered to determine IQ scores. Multi-variate regression was applied to reveal correlations between CBF and IQ scores, accounting for age, sex and global mean CBF. Voxel Based Morphometry (VBM) analysis, which measures regional cortical volume, was performed as a control. Regression analyses were further performed on CBF data with adjustment of regional gray matter density (GMD). A positive correlation between CBF and IQ scores was primarily seen in the subgenual/anterior cingulate, right orbitofrontal, superior temporal and right inferior parietal regions. An inverse relationship between CBF and IQ was mainly observed in bilateral posterior temporal regions. After adjusting for regional GMD, the correlatons between CBF and IQ in the subgenual/anterior cingulate cortex, right orbitofrontal, superior temporal regions and left insula remained significant. These findings support the Parieto-Frontal Integration Theory of intelligence, especially the role of the subgenual/anterior cingulate cortex in the neural networks associated with intelligence. The present study also demonstrates the unique value of CBF in assessing brain-behavior relationships, in addition to structural morphometric measures.
참고문헌 (32)
- Ashburner, J., "Voxel-based morphometry--the methods", Neuroimage, 11(6), pp.805~821 (2000)
- Biagi, L., "Age dependence of cerebral perfusion assessed by magnetic resonance continuous arterial spin labeling", Journal of Magnetic Resonance Imaging, 25(4), pp.696~702 (2007)
- Bush, G., "Cognitive and emotional influences in anterior cingulate cortex", Trends in cognitive sciences, 4(6), pp.215~222 (2000)
- Casey, B. J., "The role of the anterior cingulate in automatic and controlled processes: A developmental neuroanatomical study", Developmental Psychobiology, 30(1), pp.61~69 (1997)
- Colom, R., "Distributed brain sites for the g-factor of intelligence", Neuroimage, 31(3), pp.1359~1365 (2006)
- Démonet, J. F., "Renewal of the neurophysiology of language: functional neuroimaging", Physiological Reviews, 85(1), pp.49~95 (2005)
- Drevets, W.C, "Reciprocal suppression of regional cerebral blood flow during emotional versus higher cognitive processes: implications for interactions between emotion and cognition", Cognition Emotion, 12, pp.353~385 (1998)
- Gignac, G., "Factors In uencing the Relationship Between Brain Size and Intelligence. The scientific study of general intelligence" (2003), New York: Pergamon
- Gong, Q. Y., "Voxel-based morphometry and stereology provide convergent evidence of the importance of medial prefrontal cortex for fluid intelligence in healthy adults", Neuroimage, 25(4), pp.1175~1186 (2005)
- Haier, R. J., "Intelligence and changes in regional cerebral glucose metabolic rate following learning", Intelligence, 16(3), pp.415~426 (1992)
- Jain, V., "Precision and accuracy of arterial spin labeling perfusion MRI in the pediatric population", Proc Int Soc Magn Reson Med, 18, pp.2040~ (2010)
- Jung, R. E., "The parieto-frontal integration theory (P-FIT) of intelligence: Converging neuroimaging evidence", Behavioral and Brain Sciences, 30(02), pp.135~154 (2007)
- Mayberg, H. S., "Deep brain stimulation for treatment-resistant depression", Neuron, 45(5), pp.651~660 (2005)
- McDaniel,M.A, "Big-brained people are smarter: A meta-analysis of the relationship between in vivo brain volume and intelligence", Intelligence, 33(4), pp.337~346 (2005)
- Miller, B. L., "The human frontal lobes: Functions and disorders" (2007), The Guilford Press
- Nagy, Z., "Maturation of white matter is associated with the development of cognitive functions during childhood", Journal of Cognitive Neuroscience, 16(7), pp.1227~1233 (2004)
- Rosenbaum, J. L, "Higher neonatal cerebral blood flow correlates with worse childhood neurologic outcome", Neurology, 49(4), pp.1035~1041 (1997)
- Shaw, P., "Intellectual ability and cortical development in children and adolescents", Nature, 440(7084), pp.676~679 (2006)
- Sowell, E. R., "Longitudinal mapping of cortical thickness and brain growth in normal children", The Journal of Neuroscience, 24(38), pp.8223~8231 (2004)
- Strouse, J. J., "Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA)", Blood, 108(1), pp.379~381 (2006)
- Strouse, J. J., "Primary hemorrhagic stroke in children with sickle cell disease is associated with recent transfusion and use of corticosteroids", Pediatrics, 118(5), pp.1916~1924 (2006)
- Taki, Y., "Correlation between gray matter density adjusted brain perfusion and age using brain MR images of 202 healthy children" (2011), Human Brain Mapping
- Thacker, N. A, "Tutorial: A Critical Analysis of Voxel Based Morphometry (VBM)" (2005), Manchester: University of Manchester
- Toga, A. W., "Mapping brain maturation", Trends in Neurosciences, 29(3), pp.148~159 (2006)
- Vossel, S., "Visual extinction in relation to visuospatial neglect after right hemispheric stroke: quantitative assessment and statistical lesion-symptom mapping", Journal of Neurology, Neurosurgery & Psychiatry, 82(8), pp.862~ (2011)
- Wang, J., "Arterial spin labeling perfusion MRI", pp.326~343 (2009), Neuroimaging in Developmental Neuroscience
- Wang, J., "Pediatric perfusion MR imaging using arterial spin labeling", Neuroimaging Clinics of North America, 16(1), pp.149~167 (2006)
- Wang, J., "Amplitude-modulated Continuous Arterial Spin-labeling 3.0-T Perfusion MR Imaging with a Single Coil: Feasibility Study", Radiology, 235(1), pp.218~228 (2005)
- Wechsler, D, "Manual for the Wechsler Intelligence Scale for children" (1974), revised. Psychological Corp
- Wechsler, D, "Wechsler abbreviated scale of intelligence" (1999), Psychological Corp
- Wu, W. C., "A theoretical and experimental investigation of the tagging efficiency of pseudocontinuous arterial spin labeling", Magnetic Resonance in Medicine, 58(5), pp.1020~1027 (2007)
- Zago, L., "Distinguishing visuospatial working memory and complex mental calculation areas within the parietal lobes", Neuroscience letters, 331(1), pp.45~49 (2002)