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논문KCI 등재

K-WMS-IV 디자인 소검사의 임상적 유용성: 경도인지장애 환자의 수행 특징

Clinical utility of the Design subtest of the K-WMS-IV: Visuo-spatial memory performance of the patients with mild cognitive impairment

황순택|박광배|홍상황|신민영|최진영|이준영|김지혜|배솔지
사회과학연구소 (Institute of Social Sciences SOGANG UNIVERSITY)|2017.12|지역과 세계 (Locality and Globality: International Journal of Social Sciences)|제41권 제3호|pp. 49-74|DOI 10.33071/ssricb.41.3.201712.49

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참고문헌

키워드

인지노화amnestic MCI시·공간기억 평가대상-공간 연합기억 평가K-WMS-IV 디자인 소검사Visuo-spatial memoryamnestic mild cognitive impairmentK-WMS-IVDesign subtestROC analysi
주제분류기타사회과학

초록

본 연구는 기억상실형 경도인지장애(amnestic Mild Cognitive Impairment; amnestic MCI) 집단과 정상 노화 집단의 시·공간 기억 기능을 비교함으로써 K-WMS-IV 디자인 소검사의 임상적 유용성을 확인하기 위해 실시되었다. 디자인 소검사의 대상, 공간, 연합 기억 점수를 이용하여 집단 간 수행 양상을 비교하였으며, 두 집단을 변별하는데 있어서 이 세 하위 평가영역의 예측력과 판별력을 확인하였다. 연구 결과, 두 집단 간의 수행 차이는 즉각 조건에서 두드러지게 나타나고 있었다. 두 집단 간에 대상기억에서의 수행 차이는 유의하지 않았으나, amnestic MCI 집단은 정상노화 집단에 비해 공간기억과 연합기억의 수행이 유의하게 저조한 것으로 나타났다. 특히, 연합기억은 로지스틱 회귀분석에서 대상기억과 공간기억의 효과를 통제한 후에도 amnestic MCI 집단을 유의하게 예측하였다. ROC 분석에서도 진단적인 정확도를 의미하는 곡선하면적(Area Under the ROC Curve, AUCs)이 공간기억과 연합기억에 대해 각각 .71과 .73으로 양호한 수준으로 확인되었다. 이러한 결과는 K-WMS-IV의 디자인 소검사의 하위점수들이 amnestic MCI 환자들을 진단하고 평가하는 데 임상적으로 유용함을 시사한다.

Abstract

This study was conducted to confirm the clinical utility of the Design subtest of the K-WMS-IV in detecting mild cognitive impairment, high risk of Alzheimer's dementia. We compared the performance of the patients with amnestic MCI to healthy controls in three subcomponents of Design, which were object, spatial, object-spatial binding memory. The results were as follows. First, amnestic MCI patients showed significantly lower performance in immediate spatial memory and object-location binding memory, and delayed object-location binding memory than healthy controls, whilst their object memory were intact. Second, immediate object-spatial binding memory was the only significant predictor on amnestic MCI in logistic regression analysis. Third, the Area Under the ROC Curve(AUCs) of the immediate spatial memory and object-spatial binding memory were 'fair', .71 and .74, respectively. In conclusion, the subcomponents score of the Design test was useful in detecting the characteristic pattern of the visuo-spatial memory performance in amnestic MCI, and these results suggested that the Design subtest of the K-WMS-IV could enhance the diagnostic accuracy.

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