The Effect of Samul-tanggahyangbuja on Depression and Learning on Repeated Stress in Ovariectomized Rats
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Objectives: In this research, the effect of samul-tanggahyangbuja on depressionand learning in ovariectomized rats subjected to repetitive stress were assessed. Samul-tanggahyangbuja is the prescription consisting of Samul-tang and Cyperi Rhizoma. Methods: Ovariectomized rats were repeatedly stressed over a 2-week period. After being orally medicated with samul-tanggahyangbuja (100 or 400 mg/kg), ratsperformed the Morris water maze test and forced swimming test, and social explorationwas assessed in a behavior test. As well, sucrose intake was measured and measurementsof blood serum corticosterone and the change of interleukin-1β (IL-1β) and tumornecrosis factor-α (TNF-α) in blood samples were made. Results:1. In the Morris water maze test, rats medicated with 100 mg samul-tanggahyangbujamastered the maze in a shorter time on the 4th day in comparison with the controlgroup, while rats medicated with 400 mg samul-tanggahyangbuja mastered the mazemore quickly (p<0.05 on the 3rd day ; p<0.01 on the 4th day, as compared to control). 2. Immobility time in the forced swimming test was significantly decreased in ratsreceiving 400 mg samul-tanggahyangbuja compared with the control group (p<0.05). 3. Sucrose intake and active social behavior of rats receiving 400 mg samultanggahyangbujawere markedly increased in comparison with the control group (p<0.01). 4. Blood serum corticosterone measurements revealed decreased blood serumcorticosterone level after medicating with samul-tanggahyangbuja. But it was notstatistically significant. 5. Treatment with either dose of samul-tanggahyangbuja significantly reducedIL-1β and TNF-α (p<0.05). Conclusions: These results suggest that samul-tanggahyangbuja possesses theanti-depressant and cognitive-enhancing activities related to menopause.
Abstract
Objectives: In this research, the effect of samul-tanggahyangbuja on depressionand learning in ovariectomized rats subjected to repetitive stress were assessed. Samul-tanggahyangbuja is the prescription consisting of Samul-tang and Cyperi Rhizoma. Methods: Ovariectomized rats were repeatedly stressed over a 2-week period. After being orally medicated with samul-tanggahyangbuja (100 or 400 mg/kg), ratsperformed the Morris water maze test and forced swimming test, and social explorationwas assessed in a behavior test. As well, sucrose intake was measured and measurementsof blood serum corticosterone and the change of interleukin-1β (IL-1β) and tumornecrosis factor-α (TNF-α) in blood samples were made. Results:1. In the Morris water maze test, rats medicated with 100 mg samul-tanggahyangbujamastered the maze in a shorter time on the 4th day in comparison with the controlgroup, while rats medicated with 400 mg samul-tanggahyangbuja mastered the mazemore quickly (p<0.05 on the 3rd day ; p<0.01 on the 4th day, as compared to control). 2. Immobility time in the forced swimming test was significantly decreased in ratsreceiving 400 mg samul-tanggahyangbuja compared with the control group (p<0.05). 3. Sucrose intake and active social behavior of rats receiving 400 mg samultanggahyangbujawere markedly increased in comparison with the control group (p<0.01). 4. Blood serum corticosterone measurements revealed decreased blood serumcorticosterone level after medicating with samul-tanggahyangbuja. But it was notstatistically significant. 5. Treatment with either dose of samul-tanggahyangbuja significantly reducedIL-1β and TNF-α (p<0.05). Conclusions: These results suggest that samul-tanggahyangbuja possesses theanti-depressant and cognitive-enhancing activities related to menopause.
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