한방 난임 치료 시범사업에 참가한 여성의 임신 성공에 영향을 미치는 요인에 관한 연구
A Study on Factors Influencing Pregnancy in the Pilot Project for Korean Medical Treatment for Subfertility
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Objectives: This study aims to identify associated factors in female infertilitytreatment using herbal medicine, acupuncture and moxibustion. Methods: Acupuncture and moxibustion treatments were performed with intakeof herbal medicines (Jokyungjongoktanggagam-bang, Sutaehwangagam-bang) forsix menstrual cycles in 32 subfertile women. The variables selected for initial analysiswere age, duration and type of infertility, frequency of previous In Vitro Fertilization(IVF) and live births, weekly frequency of sexual intercourse, number of treatmentcycles, endometrial thickness on MCD15 and hormonal parameter (anti-mullerianhormone, follicle-stimulating hormone, luteinizing hormone, estrone). Results: Six patients became pregnant (18.75%) and seven patients withdrew. Factors influenced pregnancy were age (≤35 years), a shorter duration of infertility(<6 years), frequency of IVF (≤3), anti-mullerian hormone level (>1 ng/ml), andnumber of treatment cycles(≤3 cycles). Conclusions: Korean medicine is a useful and optimized treatment option forwomen with younger age, fewer previous IVF cycles, shorter infertile durationand normal anti-mullerian hormone level at first 3 cycles of treatment.
Abstract
Objectives: This study aims to identify associated factors in female infertilitytreatment using herbal medicine, acupuncture and moxibustion. Methods: Acupuncture and moxibustion treatments were performed with intakeof herbal medicines (Jokyungjongoktanggagam-bang, Sutaehwangagam-bang) forsix menstrual cycles in 32 subfertile women. The variables selected for initial analysiswere age, duration and type of infertility, frequency of previous In Vitro Fertilization(IVF) and live births, weekly frequency of sexual intercourse, number of treatmentcycles, endometrial thickness on MCD15 and hormonal parameter (anti-mullerianhormone, follicle-stimulating hormone, luteinizing hormone, estrone). Results: Six patients became pregnant (18.75%) and seven patients withdrew. Factors influenced pregnancy were age (≤35 years), a shorter duration of infertility(<6 years), frequency of IVF (≤3), anti-mullerian hormone level (>1 ng/ml), andnumber of treatment cycles(≤3 cycles). Conclusions: Korean medicine is a useful and optimized treatment option forwomen with younger age, fewer previous IVF cycles, shorter infertile durationand normal anti-mullerian hormone level at first 3 cycles of treatment.
참고문헌 (37)
- 대한한방부인과학회, "한방여성의학", pp.203~217 (2012), 의성당
- 허준, "동의보감", pp.1745~ (2005), 동의보감출판사
- 김준태, "불임에 응용된 침구치료혈에 관한 문헌적 고찰", 대한침구학회지, 14(2), pp.93~113 (1997)
- Ried K, "Efficacy of Traditional Chinese Herbal Medicine in the management of female infertility: a systematic review", Complement Ther Med, 19(6), pp.319~331 (2011)
- 저출산 극복을 위한 불임부부 지원사업 현황과 정책방향, "황나미", 한국보건사회연구원, ~ (2010)
- 유심근, "여성 불임 원인에 대한 문헌적 고찰", 대한한의학회지, 6(1), pp.60~67 (2000)
- 윤정석, "여성불임의 침치료와 구치료에 대한 문헌적 비교연구", 대한한방부인과학회지, 13(1), pp.532~556 (2000)
- 조진형, "IVF 시술 실패한 여성 불임환자 1례와 남성 불임환자 1례의 임상보고", 대한한방부인과학회지, 25(4), pp.94~104 (2012), 대한한방부인과학회
- 정아롱, "원인불명으로 진단받은 속발성 불임환자 1례의 임상보고", 대한한방부인과학회지, 20(4), pp.234~243 (2007), 대한한방부인과학회
- 위효선, "꽃마을한방병원 韓方婦人科에 不姙을主訴로 來院한 患者에 대한 實態分析", 대한한방부인과학회지, 18(1), pp.218~233 (2005), 대한한방부인과학회
- 장희재, "한방병원에 내원한 여성 불임 환자의 실태 변화 연구", 대한한방부인과학회지, 23(3), pp.184~191 (2010), 대한한방부인과학회
- 권수경, "최근 3년간 일개 불임전문 한방병원에 내원한 불임환자의 실태분석과 한방불임치료정책에 대한 제언", 대한한의학회지, 27(2), pp.44~56 (2006), 대한한의학회
- 황도연, "신증방약합편", pp.173~ (2002), 영림사
- 박영선, "체외수정 시술 전 한방치료가 여성 불임 환자의 임신성공율에 미치는 영향", 대한한의학회지, 32(5), pp.25~40 (2011), 대한한의학회
- 장석순, "醫學衷中參西錄", pp.640~643 (1999), 의성당
- Steptoe PC, "Reimplantation of a human embryo with subsequent tubal pregnancy", Lancet, 1(7965), pp.880~882 (1976)
- Nygren KG, "International Committee for Monitoring Assisted Reproductive Technology(ICMART)world report : assisted reproductive technology 2003", Fertil Steril, 95(7), pp.2209~2222 (2011)
- Ng EH, "The role of acupuncture in the management of subfertility", Fertil Steril, 90(1), pp.1~13 (2008)
- Huang JY, "In vitro fertilisation treatment and factors affecting success", Best Pract Res Clin Obstet Gynaecol, 26(6), pp.777~788 (2012)
- Pouly JL, "Factors affecting the cumulative live birth rate in IVF cycles. Retrospective analysis of a 1001 couples cohort", Gynecol Obstet Fertil, 40(4), pp.219~225 (2012)
- Merviel P, "Predictive factors for pregnancy after intrauterine insemination(IUI) : an analysis of 1038 cycles and a review of the literature", Fertil Steril, 93(1), pp.79~88 (2010)
- 이도근, "여성의 연령이 체외수정 시술의 예후에 미치는 영향에 관한 연구", 대한산부인과학회지, 39(8), pp.1489~1496 (1996)
- Dodson WC, "Controlleded ovarian hyperstimulation and intrauterine insemination for treatemnt of infertility", Fertil Steril, 55(3), pp.457~467 (1991)
- National Collaborating Centre for Women’s and Children’s Health, "Fertility: Assessment and Treatment for People with Fertility Problems", pp.101~120 (2004), RCOG Press
- Kang BM, "Effect of age on intrauterine insemination with frozen donor sperm", Obstet Gynecol, 88(1), pp.93~98 (1996)
- Abdalla HI, "Age, pregnancy and miscarriage : uterine versus ovarian factors", Hum Reprod, 8, pp.1512~1517 (1993)
- 양윤석, "CC", hMG 배란유도 인공수정시 치료 결과에영향을 주는 요인, 2004, pp.47(7), 1376~1384[DOI]
- Zadehmodarres S, "Intrauterine insemination with husband semen : an evaluation of pregnancy rate and factors affecting outcome", J Assist Reprod Genet, 26(1), pp.7~11 (2009)
- Nuojua-Huttunen S, "Intrauterine insemination treatment in subfertility : an analysis of factors affecting outcome", Hum Reprod, 14(3), pp.698~703 (1999)
- Templeton A, "Factors that affect outcome of in-vitro fertilization treatment", Lancet, 348(9039), pp.1402~1406 (1996)
- 강은희, "과배란유도주기에서의 자궁강내 인공수정시 초음파로 관찰된 자궁내막의 특성과 임신율과의 상관관계", 대한산부인과학회지, 39(2), pp.365~373 (1996)
- La Marca A, "Anti-Mullerian hormone(AMH)as a predictive marker in assisted reproductive technology(ART)", Hum Reprod Update, 16(2), pp.113~130 (2010)
- Jayaprakasan K, "A prospective, comparative analysis of anti-Müllerian hormone, inhibin-B, and threedimensional ultrasound determinants of ovarian reserve in the prediction of poor response to controlled ovarian stimulation", Fertil Steril, 93(3), pp.855~864 (2010)
- Nelson SM, "Anti-Müllerian hormone-based approach to controlled ovarian stimulation for assisted conception", Hum Reprod, 24(4), pp.867~875 (2009)
- Broer SL, "The role of anti-Müllerian hormone assessment in assisted reproductive technology outcome", Curr Opin Obstet Gynecol, 22(3), pp.193~201 (2010)
- 대한한의사협회 저출산, 고령화 특별대책위원회, "난임한방임상진료지침", 대한한의사협회, 6~7 (2010)
- Siverberg KM, "A prospective randomized trial comparing two different intrauterine insemination regimens in controlled hyperstimulation cycles", Fertil Steril, 57(2), pp.357~361 (1992)