한열변증을 통한 열증 대상자에 산양삼과 재배인삼의 상부 승열 작용에 대한 인체적용시험
Clinical Trial for the Heat-Rising Action of Ginseng and Cultivated Wild Ginseng to The Subject Diagnosed as Heat Pattern by Cold-Heat Patternization
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objectives: The aim of this trial is to investigate the effect of Ginseng and Wild Cultivated Ginseng to Heat pattern subject. Methods: Eighty-nine Subjects were diagnosed as heat pattern by Cold-Heat Patternization and divided into Ginseng group (n=30), Wild Cultivated Ginseng group (n=31) and Placebo group (n=28) in their 1 st visit. In each visit, The researchers measured the subject’s facial temperature using the infrared thermometer (Testo 835-T1). After that, The subjects were asked to mark the current score of flushing on the Visual Analogue Scale (VAS) and to complete the Chalder-Fatigue Scale (CFS) in each visit. The subjects took the test drug for one week and returned the remaining drug on the 2nd visit. The trial result was analyzed with one-way ANOVA using SPSS for Windows version 18. Results: 1. Systolic blood pressure was significantly lower in the Ginseng group and Wild Cultivated Ginseng group than in the control group (p=0.021). 2. There was no significant difference in facial temperature between each groups. 3. The current score of flushing showed the greatest decrease in the Ginseng group compared to the other groups but there was no significant difference (p=0.205). 4. The score of Chalder-Fatigue Scale was decreased in all groups but not statistically significant (p=0.180). Conclusions: This study showed that taking Ginseng extract and Wild Cultivated Ginseng extract do not affect to heat-rising reaction to the subjects diagnosed as heat pattern.
Abstract
Objectives: The aim of this trial is to investigate the effect of Ginseng and Wild Cultivated Ginseng to Heat pattern subject. Methods: Eighty-nine Subjects were diagnosed as heat pattern by Cold-Heat Patternization and divided into Ginseng group (n=30), Wild Cultivated Ginseng group (n=31) and Placebo group (n=28) in their 1 st visit. In each visit, The researchers measured the subject’s facial temperature using the infrared thermometer (Testo 835-T1). After that, The subjects were asked to mark the current score of flushing on the Visual Analogue Scale (VAS) and to complete the Chalder-Fatigue Scale (CFS) in each visit. The subjects took the test drug for one week and returned the remaining drug on the 2nd visit. The trial result was analyzed with one-way ANOVA using SPSS for Windows version 18. Results: 1. Systolic blood pressure was significantly lower in the Ginseng group and Wild Cultivated Ginseng group than in the control group (p=0.021). 2. There was no significant difference in facial temperature between each groups. 3. The current score of flushing showed the greatest decrease in the Ginseng group compared to the other groups but there was no significant difference (p=0.205). 4. The score of Chalder-Fatigue Scale was decreased in all groups but not statistically significant (p=0.180). Conclusions: This study showed that taking Ginseng extract and Wild Cultivated Ginseng extract do not affect to heat-rising reaction to the subjects diagnosed as heat pattern.
참고문헌 (21)
- Compilation Committee of Oriental Medicine Text book, "Herbal Medicine", pp.572~575 (2007), Younglimsa
- 정희선, "인삼·산양삼·자연산 산삼의 ginsenoside 함량 분석 및 홍삼화 후의 변화 관찰", Journal of Pharmacopuncture, 13(1), pp.63~77 (2010), 대한약침학회
- Kwon Ki-Rok, "산삼(山蔘)에 대한 문헌적(文獻的) 고찰(考察)", Journal of Pharmacopuncture, 6(2), pp.67~75 (2003), 대한약침학회[DOI]
- 서정철, "한국인과 중국인에서 인삼과 서양삼 복용후 전신증상 - 이중맹검 무작위배정 임상시험 -", Journal of Ginseng Research, 29(1), pp.27~36 (2005), 고려인삼학회
- Kim SH, "Effect of Korean Red Ginseng and Western Ginseng on Body Temperature, Pulse Rate, Clinical Symptoms and the Hematological Changes in Human", Journal of Ginseng Research, 40(1), pp.1~16 (1995)
- Baek TS, "Health Test for Searching of Correlation and the Index of the Cold-heat Patternization Comparison of the Questionnaires for the Cold-heat Patternization and the Ordinary", The Journal of the Korea Institute of Oriental Medical Diagnostics, 9(2), pp.145~151 (2005)
- Chalder T, "Development of a fatigue scale", J Psychosom Res, 37(2), pp.147~153 (1993)
- Yang Z, "Ginsenoside Rd elicits Th1 and Th2 immune responses to ovalbumin in mice", Vaccine, 25(1), pp.161~169 (2007)
- Reay JL, "Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained ‘mentally demanding'tasks", J Psychopharmacol, 20(6), pp.771~781 (2006)
- Lee SH, "The antistress effect of ginseng total saponin and ginsenoside Rg3 and Rb1 evaluated by brain polyamine level under immobilization stress", Pharmacological Research, 54(1), pp.46~49 (2006)
- Su CF, "Increase of acetylcholine release by Panax ginseng root enhances insulin secretion in Wistar rats", Neurosci Lett, 412(2), pp.101~104 (2007)
- 권기록, "산삼과 장뇌삼 중 고려삼과 서양삼의 Pyrosequencing법에 의한 감별", 대한본초학회지, 19(4), pp.45~50 (2004), 대한본초학회
- 권기록, "The Study on Acute and Subacute Toxicity and Anti-Cancer Effects of cultivated wild ginseng Herbal acupuncture", Journal of Pharmacopuncture, 6(2), pp.7~27 (2003), 대한약침학회[DOI]
- 김경철, "山養蔘藥鍼이 유방암절제술 여성의 심박변이도, 맥파전달속도에 미치는 영향", 대한한의진단학회지, 15(3), pp.245~259 (2011), 대한한의진단학회
- Cho Hee-Chul, "An Experimental Study on Apoptosis of cultivated Wild Ginseng Distilled Herbal Acupuncture by Concentration Level", Journal of Pharmacopuncture, 7(2), pp.5~17 (2004), 대한약침학회[DOI]
- 김영진, "인삼, 한국 및 중국산 산양삼의 간 보호 효능에 관한 실험적 연구", Journal of Pharmacopuncture, 10(1), pp.101~107 (2007), 대한약침학회
- 서정철, "한국인과 중국인에서 고려삼과 화기삼의 체표온도에 대한 이중맹검-무작위배정 임상시험", 대한본초학회지, 18(2), pp.7~86 (2003), 대한본초학회
- Lim BO, "Trends and prospects of domestic and oversea ginseng industry", Bulletin of food technology, 18(2), pp.16~30 (2005)
- Heo J., "Dongeuibogam", pp.760~ (2007), Bubinbooks
- 남기열, "고려인삼의 혈압에 미치는 영향에 대한 이해", 생약학회지, 48(2), pp.97~107 (2017), 한국생약학회
- 조선영, "모유수유 중 인삼의 적응증과 용량에 관한 기존한약서 고찰", 대한한방부인과학회지, 23(4), pp.57~66 (2010), 대한한방부인과학회