Extensive inflammatory reaction in facioscapulohumeral muscular dystrophy
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In facioscapulohumeral muscular dystrophy (FSHD), prominent inflammatory cellular infiltrates mimicking inflammatory myopathies are often observed in muscle biopsies. We report extensive inflammatory changes in a 16-year-old girl who was genetically confirmed as to have FSHD. Immunohistochemical staining revealed that this could be clearly distinguished from inflammatory myopathies, both in terms of cell subsets and the expression of antigenic targets. Our observations strongly suggest that the inflammatory cellular infiltrates in FSHD differ from those observed in inflammatory myopathies.
Abstract
In facioscapulohumeral muscular dystrophy (FSHD), prominent inflammatory cellular infiltrates mimicking inflammatory myopathies are often observed in muscle biopsies. We report extensive inflammatory changes in a 16-year-old girl who was genetically confirmed as to have FSHD. Immunohistochemical staining revealed that this could be clearly distinguished from inflammatory myopathies, both in terms of cell subsets and the expression of antigenic targets. Our observations strongly suggest that the inflammatory cellular infiltrates in FSHD differ from those observed in inflammatory myopathies.
참고문헌 (10)
- Tawil R, "Facioscapulohumeral muscular dystrophy", Muscle Nerve, 34, pp.1~15 (2006)
- Arahata K, "Inflammatory response in facioscapulohumeral muscular dystrophy (FSHD): immunocytochemical and genetic analyses", Muscle Nerve Suppl, 2, pp.S56~S66 (1995)
- Munsat TL, "Inflammatory myopathy with facioscapulohumeral distribution", Neurology, 22, pp.335~347 (1972)
- Wulff JD, "Inflammatory facioscapulohumeral muscular dystrophy and Coats syndrome", Ann Neurol, 12, pp.398~401 (1982)
- Bacq M, "Familial myopathies with restricted distribution, facial weakness and inflammatory changes in affected muscles", J Neurol, 231, pp.295~300 (1985)
- van Deutekom JC, "Evidence for subtelomeric exchange of 3.3kb tandemly repeated units between chromosomes 4q35 and 10q26: implications for genetic counselling and etiology of FSHD1", Hum Mol Genet, 5, pp.1997~2003 (1996)
- Dalakas MC, "Polymyositis and dermatomyositis", Lancet, 362, pp.971~982 (2003)
- Bao SS, "Elevated MHC class I and II antigens in cultured human embryonic myoblasts following stimulation with gamma-interferon", Immunol Cell Biol, 68(Pt 4), pp.235~241 (1990)
- Michaelis D, "Constitutive and cytokine-induced expression of human leukocyte antigens and cell adhesion molecules by human myotubes", Am J Pathol, 143, pp.1142~1149 (1993)
- Molnár M, "Inflammatory changes in facioscapulohumeral muscular dystrophy", Eur Arch Psychiatry Clin Neurosci, 241, pp.105~108 (1991)