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Neurolymphomatosis in patients with mantle cell lymphoma diagnosed by FDG PET-CT

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초록

Neurolymphomatosis (NL) is characterized by the infiltration of malignant lymphoma cells into peripheral nerves, nerve roots, plexuses, or cranial nerves. This is a very rare complication of mantle-cell lymphoma. Diagnosing NL is made difficult by cerebrospinal fluid cytology and bone-marrow biopsy results often being negative. NL can appear as the only sign of recurrence in a patient with a previous diagnosis of lymphoma. Here we present two cases of NL in patients with mantle-cell lymphoma diagnosed by positron emission tomography with deoxy-fluoro-D-glucose integrated with computed tomography.

Abstract

Neurolymphomatosis (NL) is characterized by the infiltration of malignant lymphoma cells into peripheral nerves, nerve roots, plexuses, or cranial nerves. This is a very rare complication of mantle-cell lymphoma. Diagnosing NL is made difficult by cerebrospinal fluid cytology and bone-marrow biopsy results often being negative. NL can appear as the only sign of recurrence in a patient with a previous diagnosis of lymphoma. Here we present two cases of NL in patients with mantle-cell lymphoma diagnosed by positron emission tomography with deoxy-fluoro-D-glucose integrated with computed tomography.

참고문헌 (10)

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  8. Baehring JM, "Neurolymphomatosis", Neuro Oncol, 5, pp.104~115 (2003)
  9. Gan HK, "Neurolymphomatosis: diagnosis, management, and outcomes in patients treated with rituximab", Neuro Oncol, 12, pp.212~215 (2010)
  10. Grisariu S, "Neurolymphomatosis : an International Primary CNS Lymphoma Collaborative Group report", Blood, 115, pp.5005~5011 (2010)

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