온경탕이 족부냉증에 미치는 영향에 대한 다기관 이중맹검 무작위 대조군 연구
Effect of Onkyung-tang on Cold Hypersensitivity on Feet: A Multi-center Double-blind Randomized Controlled Trial
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Objectives: This study was aimed to figure out the effect of Onkyung-tang (OKT) on cold hypersensitivity on feet in female patients. Methods: This study was designed to implement multi-center randomized clinical trial in three korean medical hospitals. The female patients who were enrolled in this study were 112 women who suffered from cold hypersensitivity on feet. They were randomly allocated into OKT group or control group in 1:1 ratio. The primary outcome was change in score of visual analogue scale of hypersensitivity on feet, and the secondary outcomes were thermometer of LU4, PC8, ST32, LR3, visual analogue scale of hypersensitivity on hands, result of cold stress test, and score of World Health Organization Quality of Life-BREF. Results: In both group, the VAS of hypersensitivity on feet and hands was decreased while taking the medicine, and the effect of decreasing the VAS continues for the 4 weeks after the end of medication (p<0.001, 0.003, 0.001). In OKT group, the body temperature difference in lower extremity (ST32-LR3) was steadily decreased at every visit and it was statistically significant(p=0.003, <0.001). On the other hand, in control group, the body temperature difference in lower extremity was decreased only while taking the medicine (p<0.001). Conclusions: OKT significantly reduced discomfort coldness on feet in patients, and the effect of treatment was maintained at least for four weeks after medication.
Abstract
Objectives: This study was aimed to figure out the effect of Onkyung-tang (OKT) on cold hypersensitivity on feet in female patients. Methods: This study was designed to implement multi-center randomized clinical trial in three korean medical hospitals. The female patients who were enrolled in this study were 112 women who suffered from cold hypersensitivity on feet. They were randomly allocated into OKT group or control group in 1:1 ratio. The primary outcome was change in score of visual analogue scale of hypersensitivity on feet, and the secondary outcomes were thermometer of LU4, PC8, ST32, LR3, visual analogue scale of hypersensitivity on hands, result of cold stress test, and score of World Health Organization Quality of Life-BREF. Results: In both group, the VAS of hypersensitivity on feet and hands was decreased while taking the medicine, and the effect of decreasing the VAS continues for the 4 weeks after the end of medication (p<0.001, 0.003, 0.001). In OKT group, the body temperature difference in lower extremity (ST32-LR3) was steadily decreased at every visit and it was statistically significant(p=0.003, <0.001). On the other hand, in control group, the body temperature difference in lower extremity was decreased only while taking the medicine (p<0.001). Conclusions: OKT significantly reduced discomfort coldness on feet in patients, and the effect of treatment was maintained at least for four weeks after medication.
참고문헌 (21)
- Jang JB, "Study on the Definition of the Female’s PartColdness Syndrome", Journal of Korean Medicine, 15(2), pp.397~411 (1994)
- 고승우, "수부냉증 진단방법에 관한 기초연구", 대한한방내과학회지, 36(3), pp.228~235 (2015), 대한한방내과학회
- 이동녕, "한의표준임상진료지침 개발을 위한 수족냉증에 대한 한의사의 인식과 치료현황", 대한한방부인과학회지, 30(3), pp.92~116 (2017), 대한한방부인과학회[DOI]
- Kim CM, "Diagnosis and treatment of cold hands", feet syndrome, 2004, pp.25(11), 273~277
- Choi WS, "The Prevalence of Raynaud’s Disease among the Complaints of Abnormal Sensation on Hands and Feet", J Korean Acad Fam Med, 24(12), pp.1085~1091 (2003)
- Lee SR, "Shanghanlun", pp.568~608 (1996), Kyunghee university publishing Co
- 권나연, "수족냉증 환자의 월경 특성에 관한 연구", 대한한방부인과학회지, 32(3), pp.174~191 (2019), 대한한방부인과학회[DOI]
- 권정연, "여성 수족냉증 환자의 임상 특성에 관한 연구", 대한한의학회지, 39(2), pp.64~79 (2018), 대한한의학회[DOI]
- 박연경, "수족냉증 환자의 HRV 특성연구", 대한한방부인과학회지, 28(1), pp.92~101 (2015), 대한한방부인과학회
- Kim DH, "Standardization of Diagnosis of Cold Hypersensitivity of Hands and Feet by D.I.T.I", J Korean Obstet Gynecol, 14(2), pp.129~134 (2001)
- 김진우, "수족냉증 중증도 판단에 영향을 미칠 수 있는 요인 분석", 대한한방부인과학회지, 25(4), pp.38~45 (2012), 대한한방부인과학회
- 선승호, "수족냉증 치료 표준화를 위한 델파이 연구", 대한예방한의학회지, 19(3), pp.131~140 (2015), 대한예방한의학회
- Park KS, "Efficacy and safety of Korean red ginseng for cold hypersensitivity in the hands and feet : A randomized, double-blind, placebo-controlled trial", Journal of Ethnopharmacology, 158(Part A), pp.25~32 (2014)
- Harper A, "Development of the World Health Organization WHOQOL-BREF quality of life assessment", Psycol Med, 28(3), pp.551~558 (1998)
- The Society of Korean Medicine Obstetrics and Gynecology, "Korean Medicine Obstetrics & Gynecology Ha", pp.888~ (2012), Euiseongdang Publishing Co
- The Society of Korean Medicine Obstetrics and Gynecology, "JinRyoPyeonRam (Manual of Korean Gynecology)", pp.304~ (2017), Euiseongdang Publishing Co
- Heo J, "Dongeuibogam", pp.1751~ (2010), Dongeuibogam publishing Co
- Hwang DY, "Bangyackhappyun", pp.171~172 (2011), Yeongnim Publishing Co
- 이용태, "溫經湯에 관한 形象醫學的 연구", 동의생리병리학회지, 19(2), pp.339~346 (2005), 한의병리학회
- Kim KJ, "A Case about the Effect of Onkyung-tang on Acne", pp.2010
- Kwon CN, "The Effect of Onkyung-tang on Uterine Changes of Ovariectomized Rats", J Korean Obstet Gynecol, 14(2), pp.56~68 (2001)