Comparison of the Demographic and Laboratory Profiles of Patients with Aseptic Meningitis and Encephalitis: Significance of Age and C-reactive Protein
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Background: Viruses can cause either meningitis or encephalitis. It is unclear why some people suffer from aseptic meningitis,and others acquire aseptic encephalitis when infected with the same viral pathogens. The aim of this study wasto compare demographic and laboratory factors between patients with aseptic meningitis and encephalitis. Methods: Thedemographic and laboratory differences were analyzed according to age, sex, diabetes, hypertension, C-reactive proteinin the blood, white blood cell and protein in the cerebrospinal fluid, and glucose ratio (cerebrospinal fluid/blood). Additionally, we analyzed the nation-wide differencesin age between the patients with aseptic meningitis and those withencephalitis in Korea. Results: The patients with aseptic encephalitis were older, more likely to have hypertension, andhad higher levels of C-reactive protein than did the patients with aseptic meningitis. However, the numbers of whiteblood cells in the cerebrospinal fluid were significantly higher in the patients with meningitis than in the patients withencephalitis. Multivariable analysis revealed that age >49 years, hypertension and a C-reactive protein level >5.81mg/dL were independent and significant variables in the prediction of aseptic encephalitis. Additionally, the patientswith aseptic encephalitis were older than those with aseptic meningitis in the nation-wide Korean database. Conclusions:Older age, hypertension, and higher levels of C-reactive protein are useful factors for the prediction of asepticencephalitis.(Korean J Clin Neurophysiol 2014;16:55-61)
Abstract
Background: Viruses can cause either meningitis or encephalitis. It is unclear why some people suffer from aseptic meningitis,and others acquire aseptic encephalitis when infected with the same viral pathogens. The aim of this study wasto compare demographic and laboratory factors between patients with aseptic meningitis and encephalitis. Methods: Thedemographic and laboratory differences were analyzed according to age, sex, diabetes, hypertension, C-reactive proteinin the blood, white blood cell and protein in the cerebrospinal fluid, and glucose ratio (cerebrospinal fluid/blood). Additionally, we analyzed the nation-wide differencesin age between the patients with aseptic meningitis and those withencephalitis in Korea. Results: The patients with aseptic encephalitis were older, more likely to have hypertension, andhad higher levels of C-reactive protein than did the patients with aseptic meningitis. However, the numbers of whiteblood cells in the cerebrospinal fluid were significantly higher in the patients with meningitis than in the patients withencephalitis. Multivariable analysis revealed that age >49 years, hypertension and a C-reactive protein level >5.81mg/dL were independent and significant variables in the prediction of aseptic encephalitis. Additionally, the patientswith aseptic encephalitis were older than those with aseptic meningitis in the nation-wide Korean database. Conclusions:Older age, hypertension, and higher levels of C-reactive protein are useful factors for the prediction of asepticencephalitis.(Korean J Clin Neurophysiol 2014;16:55-61)
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