Prognosis of patients with postural tachycardia syndrome: a follow-up study
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Postural tachycardia syndrome (POTS) refers to the presence of orthostatic intolerance symptoms associated with a heart rate increment of greater than 30 beats/min, usually up to 120 beats/min, on head-up tilt test. Symptoms related to POTS are usually lightheadedness, palpitations and tremor, but syncope can also occur. The pathophysiology of POTS is heterogeneous and its prognosis is uncertain. Methods: We prospectively evaluated patients who met the criteria for POTS, at baseline and follow-up, using composite autonomic symptom scores and autonomic tests to assess the autonomic function. We compared the clinical and autonomic test results between baseline and follow-up. Results: Sixty-eight patients met the inclusion criteria for POTS and forty-five patients were ultimately followed up for at least 1 year after baseline. The patients were predominantly young females (84%), with a mean age of 21 years. Most patients showed improved orthostatic symptoms and more than a quarter of patients had no longer met the criteria for POTS at follow-up. Conclusions: Most patients had a benign outcome in that they could resume their daily activities without great limitations. Our results demonstrated a relatively favorable prognosis in most patients with POTS.
Abstract
Background: Postural tachycardia syndrome (POTS) refers to the presence of orthostatic intolerance symptoms associated with a heart rate increment of greater than 30 beats/min, usually up to 120 beats/min, on head-up tilt test. Symptoms related to POTS are usually lightheadedness, palpitations and tremor, but syncope can also occur. The pathophysiology of POTS is heterogeneous and its prognosis is uncertain. Methods: We prospectively evaluated patients who met the criteria for POTS, at baseline and follow-up, using composite autonomic symptom scores and autonomic tests to assess the autonomic function. We compared the clinical and autonomic test results between baseline and follow-up. Results: Sixty-eight patients met the inclusion criteria for POTS and forty-five patients were ultimately followed up for at least 1 year after baseline. The patients were predominantly young females (84%), with a mean age of 21 years. Most patients showed improved orthostatic symptoms and more than a quarter of patients had no longer met the criteria for POTS at follow-up. Conclusions: Most patients had a benign outcome in that they could resume their daily activities without great limitations. Our results demonstrated a relatively favorable prognosis in most patients with POTS.
참고문헌 (14)
- Low PA, "Postural tachycardia syndrome (POTS)", Neurology, 45(4 Suppl 5), pp.S19~S25 (1995)
- Carew S, "A review of postural orthostatic tachycardia syndrome", Europace, 11, pp.18~25 (2009)
- Thieben MJ, "Postural orthostatic tachycardia syndrome:the Mayo clinic experience", Mayo Clin Proc, 82, pp.308~313 (2007)
- Stewart JM, "Chronic orthostatic intolerance and the postural tachycardia syndrome (POTS)", J Pediatr, 145, pp.725~730 (2004)
- Grubb BP, "The postural tachycardia syndrome:a concise guide to diagnosis and management", J Cardiovasc Electrophysiol, 17, pp.108~112 (2006)
- Sandroni P, "Postural tachycardia syndrome: clinical features and follow-up study", Mayo Clin Proc, 74, pp.1106~1110 (1999)
- Sletten DM, "COMPASS 31: a refined and abbreviated composite autonomic symptom score", Mayo Clin Proc, 87, pp.1196~1201 (2012)
- Jacob G, "The neuropathic postural tachycardia syndrome", N Engl J Med, 343, pp.1008~1014 (2000)
- Furlan R, "Chronic orthostatic intolerance: a disorder with discordant cardiac and vascular sympathetic control", Circulation, 98, pp.154~159 (1998)
- Raj SR, "Renin-aldosterone paradox and perturbed blood volume regulation underlying postural tachycardia syndrome", Circulation, 111, pp.1574~1582 (2005)
- Freitas J, "Clinical improvement in patients with orthostatic intolerance after treatment with bisoprolol and fludrocortisone", Clin Auton Res, 10, pp.293~299 (2000)
- Low PA, "Postural tachycardia syndrome (POTS)", J Cardiovasc Electrophysiol, 20, pp.352~358 (2009)
- Sousa A, "Long-term follow-up of patients with postural tachycardia syndrome", Clin Auton Res, 22, pp.151~153 (2012)
- Kimpinski K, "A prospective, 1-year follow-up study of postural tachycardia syndrome", Mayo Clin Proc, 87, pp.746~752 (2012)