한방 치료로 고안드로겐혈증을 개선한 다낭성 난소 증후군 연속증례연구
A Case Series of Polycystic Ovary Syndrome with Improved Hyperandrogenism Treated with Korean Medicine
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Objectives: This study aims to analyze the medical record of eight cases of polycystic ovary syndrome (PCOS) in a local Korean medicine clinic, in order to provide evidence on Korean medicine treatment of PCOS and to suggest the direction of future studies. Methods: The medical records of eight cases diagnosed with PCOS based on 2003 Rotterdam Criteria and whose total testosterone level was 0.53 ng/ml and over were retrospectively analyzed. The primary outcome was total testosterone level, and the secondary outcomes included luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels, LH/FSH ratio, weight, last mentrual period (LMP), numerical rating scale (NRS) score of dysmenorrhea, and other associated symptoms pre- and post-treatment. Korean medicine treatment consists of the complex herbal prescription consisting of Yukmijihwang-tang, Baekho-tang, Daesiho-tang, and Gyejibokryeong-hwan, modified according to symptoms; acupuncture and electroacupuncture on 中脘 (CV12), 下脘 (CV10), 關元 (CV4), 石門 (CV5), 合谷 (LI4), 太衝 (LR3), 三陰交 (SP6), and 懸鍾 (GB39); and indirect moxibustion on 神闕 (CV8). Results: The average total testosterone level lowered statistically significantly after the treatment. The average FSH and LH levels lowered with insignificance, while the average LH/FSH ratio and weight lowered statistically significantly. During the treatment period of three to six months, every patient had the menstrual cycle shortened except for one case; and two cases with infertility problem succeeded in being pregnant. There was no adverse event. Conclusions: The Korean medicine treatment was found effective in treating PCOS, especially regarding hyperandrogenism, amenorrhea or oligomenorrhea, and infertility.
Abstract
Objectives: This study aims to analyze the medical record of eight cases of polycystic ovary syndrome (PCOS) in a local Korean medicine clinic, in order to provide evidence on Korean medicine treatment of PCOS and to suggest the direction of future studies. Methods: The medical records of eight cases diagnosed with PCOS based on 2003 Rotterdam Criteria and whose total testosterone level was 0.53 ng/ml and over were retrospectively analyzed. The primary outcome was total testosterone level, and the secondary outcomes included luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels, LH/FSH ratio, weight, last mentrual period (LMP), numerical rating scale (NRS) score of dysmenorrhea, and other associated symptoms pre- and post-treatment. Korean medicine treatment consists of the complex herbal prescription consisting of Yukmijihwang-tang, Baekho-tang, Daesiho-tang, and Gyejibokryeong-hwan, modified according to symptoms; acupuncture and electroacupuncture on 中脘 (CV12), 下脘 (CV10), 關元 (CV4), 石門 (CV5), 合谷 (LI4), 太衝 (LR3), 三陰交 (SP6), and 懸鍾 (GB39); and indirect moxibustion on 神闕 (CV8). Results: The average total testosterone level lowered statistically significantly after the treatment. The average FSH and LH levels lowered with insignificance, while the average LH/FSH ratio and weight lowered statistically significantly. During the treatment period of three to six months, every patient had the menstrual cycle shortened except for one case; and two cases with infertility problem succeeded in being pregnant. There was no adverse event. Conclusions: The Korean medicine treatment was found effective in treating PCOS, especially regarding hyperandrogenism, amenorrhea or oligomenorrhea, and infertility.
참고문헌 (27)
- The Compilation Committee of Textbook, "Gynecology", pp.479~434 (2018), Korea Medical Book Publishing Company
- The Society of Korean Medicine Obstetrics and Gynecology, "Oriental Obstetrics & Gynecology (2nd volume)", pp.182~185 (2016), Euiseongdang
- Soni A, "Polycystic ovary syndrome: Pathogenesis. treatment and secondary associated diseases", Journal of Drug Delivery and Therapeutics, 8(5), pp.107~112 (2018)
- Bednarska S, "The pathogenesis and treatment of polycystic ovary syndrome: What’s new", Adv Clin Exp Med, 26(2), pp.359~367 (2017)
- Setji TL, "Polycystic Ovary Syndrome: Update on Diagnosis and Treatment", The American Journal of Medicine, 127(10), pp.912~919 (2014)
- Azziz R, "Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span", The Journal of Clinical Endocrinology & Metabolism, 90(8), pp.4650~4658 (2005)
- Liu J, "Measuring the global disease burden of polycystic ovary syndrome in 194 countries : Global Burden of Disease Study 2017", Human Reproduction, 36(4), pp.1108~1119 (2021)
- Domecq JP, "Adverse effects of the common treatments for polycystic ovary syndrome : a systematic review and meta-analysis", J Clin Endocrinol Metab, 98(12), pp.4646~4654 (2013)
- 김세화, "다낭성 난소 증후군의 침치료 연구에 관한 체계적 문헌고찰", 대한한방부인과학회지, 27(2), pp.71~82 (2014), 대한한방부인과학회[DOI]
- 윤준걸, "다낭성 난소증후군의 전침 치료의 연구에 관한 체계적 문헌고찰", 대한한방부인과학회지, 31(4), pp.39~53 (2018), 대한한방부인과학회[DOI]
- 김지예, "다낭성 난소증후군 치험 1례", 대한한방부인과학회지, 27(3), pp.151~157 (2014), 대한한방부인과학회[DOI]
- Lee JS, "A Case Study on Inferility with Obesity and Polycystic Ovary", Journal of Society of Korean Medicine for Obesity Research, 5(1), pp.157~163 (2005)
- 이지현, "다낭성난소증후군으로 인한 무월경, 희발월경 환자 20명의 증례 보고", 대한한방부인과학회지, 29(3), pp.47~56 (2016), 대한한방부인과학회[DOI]
- Rotterdam ESHRE, "ASRM-Sponsored PCOS Consensus Workshop Group", Revised 2003 Consensus on Diagnostic Criteria and Long-term Health Risks Related to Polycystic Ovary Syndrome, 2004, pp.81(1), 19~25
- 정미연, "사제향부환을 투여한 다낭성난소증후군 환자 증례보고", 대한한의학회지, 39(3), pp.101~109 (2018), 대한한의학회[DOI]
- Shin SM, "A case report of primary infertility caused by polycystic ovarian syndrome.", Journal of Haehwa Medicine, 17(1), pp.173~180 (2008)
- 황보수민, "한방 치료를 통해 배란성 월경을 회복한 다낭성 난소 증후군 환자 6명의 증례보고", 대한한방부인과학회지, 32(1), pp.108~126 (2019), 대한한방부인과학회[DOI]
- 박승혁, "일개 한방병원에 내원한 다낭성 난소 증후군 환자의 특성 및 치료 분석", 대한한방부인과학회지, 32(1), pp.37~47 (2019), 대한한방부인과학회[DOI]
- 배주은, "다낭성 난소 증후군을 이환하는 난임 환자에서 통합 의학 치료의 효과 : 체계적 문헌 고찰 및 메타분석", 대한한방부인과학회지, 30(4), pp.59~76 (2017), 대한한방부인과학회[DOI]
- Heo J, "Donguibogam(東醫寶鑑)" (1981), Daesung munhwasa
- Yun YG, "Dongui Prescriptions and Interpretations(東醫方劑와 處方解說)", pp.718~719 (2011), Euiseongdang
- 송미영, "고지방 식이 유도 비만에 대한 대시호탕 추출물의 억제 효과", 한방재활의학과학회지, 18(3), pp.41~49 (2008), 한방재활의학과학회
- Han MG, "The Effects of Daesiho-Tang on Body Weight and Biochemical Changes of Rats Fed High Diet", Journal of Korea Chuna manual medicine, 2(1), pp.177~186 (2001)
- 민들레, "大柴胡湯이 3T3-L1 지방전구세포와 고지방식이 유도 비만쥐에 미치는 영향", 대한한방소아과학회지, 29(1), pp.1~14 (2015), 대한한방소아과학회
- Meridians & Acupoints Compilation Committee of Korean Oriental Medical Colleges, "Details of Meridians ＆Acupoints: a Guidebook for College Students" (2012), Jongryeonamu Publishing Company
- 권세라, "三陰交·子宮穴 전침 자극이 백서의 다낭성 난소에 미치는 영향", 대한한방부인과학회지, 16(2), pp.76~86 (2003), 대한한방부인과학회
- Yang R, "Effects of hyperandrogenism on metabolic abnormalities in patients with polycystic ovary syndrome: a meta-analysis", Reprod Biol Endocrinol, 14(1), pp.67~ (2016)