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A case of primary central nervous system lymphoma diagnosed with cerebrospinal fluid analysis: replacement brain biopsy with cerebrospinal fluid immunohistochemistry and immunoglobulin gene rearrangement

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초록

Primary central nervous system lymphoma (PCNSL) is a type of non-Hodgkin lymphoma confined to the central nervous system. Its diagnosis requires a stereotactic biopsy, which is an invasive procedure. Cerebrospinal fluid (CSF) analysis is less invasive and easier to perform than a stereotactic biopsy. We hereby report a PCNSL case diagnosed using CSF analysis and treated with systemic chemotherapy.

Abstract

Primary central nervous system lymphoma (PCNSL) is a type of non-Hodgkin lymphoma confined to the central nervous system. Its diagnosis requires a stereotactic biopsy, which is an invasive procedure. Cerebrospinal fluid (CSF) analysis is less invasive and easier to perform than a stereotactic biopsy. We hereby report a PCNSL case diagnosed using CSF analysis and treated with systemic chemotherapy.

참고문헌 (8)

  1. Grommes C, "Primary CNS lymphoma", J Clin Oncol, 35, pp.2410~2418 (2017)
  2. Kleinschmidt-DeMasters BK, "Epstein Barr virus-associated primary CNS lymphomas in elderly patients on immunosuppressive medications", J Neuropathol Exp Neurol, 67, pp.1103~1111 (2008)
  3. Scott BJ, "A systematic approach to the diagnosis of suspected central nervous system lymphoma", JAMA Neurol, 70, pp.311~319 (2013)
  4. Weller M, "Glucocorticoid treatment of primary CNS lymphoma", J Neurooncol, 43, pp.237~239 (1999)
  5. Langerak AW, "EuroClonality", BIOMED-2 guidelines for interpretation and reporting of Ig, Leukemia, pp.2012, 26[DOI]
  6. Ekstein D, "CSF analysis of IgH gene rearrangement in CNS lymphoma : relationship to the disease course", J Neurol Sci, 247, pp.39~46 (2006)
  7. Kros JM, "Analysis of immunoglobulin H gene rearrangement by polymerase chain reaction in primary central nervous system lymphoma", J Neurosurg, 97, pp.1390~1396 (2002)
  8. Baehring JM, "Immunoglobulin gene rearrangement analysis in cerebrospinal fluid of patients with lymphoproliferative processes", J Neurol Sci, 247, pp.208~216 (2006)

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