Seasonal Changes in Lower Urinary Tract Symptoms in Japanese Men With Benign Prostatic Hyperplasia Treated With α1-Blockers
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: To investigate whether seasonal changes occurred in lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). Methods: Patients aged 50 years and older with BPH treated with α1-blockers were enrolled. The International Prostate Symptom Score (IPSS), quality of life (QoL) score, maximum and average flow rate, voided volume, and postvoid residual volume were measured in summer and winter. Results: A total of 164 patients were enrolled. The total IPSS and QoL index did not show a significant difference between the 2 seasons. When the IPSS was divided into storage symptoms and voiding symptoms, storage symptoms in winter were substantially but nonsignificantly higher than those in summer (P=0.056). Of the 7 individual symptoms in the IPSS, a significant seasonal difference was observed only for nocturia, with a higher score in winter. Moreover, none of the uroflowmetric parameters showed a seasonal change. Voided volume had significant correlations with each symptom (urgency and nocturia) and overall subjective scores (storage, total IPSS, and QoL) exclusively in summer, while this correlation remained only for nocturia in winter. Conclusions: As it has generally been assumed that LUTS deteriorate in winter, the present study corroborated that the severity of storage symptoms was higher in winter than in summer, even in patients treated with α1-blockers. In contrast, a seasonal difference was not observed in the uroflowmetric parameters, which may be partly due to the loss of the correlation between subjective and objective measurements of storage symptoms in winter.
Abstract
Purpose: To investigate whether seasonal changes occurred in lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). Methods: Patients aged 50 years and older with BPH treated with α1-blockers were enrolled. The International Prostate Symptom Score (IPSS), quality of life (QoL) score, maximum and average flow rate, voided volume, and postvoid residual volume were measured in summer and winter. Results: A total of 164 patients were enrolled. The total IPSS and QoL index did not show a significant difference between the 2 seasons. When the IPSS was divided into storage symptoms and voiding symptoms, storage symptoms in winter were substantially but nonsignificantly higher than those in summer (P=0.056). Of the 7 individual symptoms in the IPSS, a significant seasonal difference was observed only for nocturia, with a higher score in winter. Moreover, none of the uroflowmetric parameters showed a seasonal change. Voided volume had significant correlations with each symptom (urgency and nocturia) and overall subjective scores (storage, total IPSS, and QoL) exclusively in summer, while this correlation remained only for nocturia in winter. Conclusions: As it has generally been assumed that LUTS deteriorate in winter, the present study corroborated that the severity of storage symptoms was higher in winter than in summer, even in patients treated with α1-blockers. In contrast, a seasonal difference was not observed in the uroflowmetric parameters, which may be partly due to the loss of the correlation between subjective and objective measurements of storage symptoms in winter.
참고문헌 (27)
- Spencer FA, "Seasonal distribution of acute myocardial infarction in the second National Registry of Myocardial Infarction", J Am Coll Cardiol, 31, pp.1226~1233 (1998)
- Inagawa T, "Primary intracerebral and aneurysmal subarachnoid hemorrhage in Izumo City, Japan. Part II: management and surgical outcome", J Neurosurg, 93, pp.967~975 (2000)
- Nakaji S, "Seasonal changes in mortality rates from main causes of death in Japan(1970--1999)", Eur J Epidemiol, 19, pp.905~913 (2004)
- Imamura T, "Cold stress induces lower urinary tract symptoms", Int J Urol, 20, pp.661~669 (2013)
- Geirsson G, "The bladder cooling reflex and the use of cooling as stimulus to the lower urinary tract", J Urol, 162, pp.1890~1896 (1999)
- Yoshimura K, "Seasonal alterations in nocturia and other storage symptoms in three Japanese communities", Urology, 69, pp.864~870 (2007)
- Watanabe T, "Seasonal changes in symptom score and uroflowmetry in patients with lower urinary tract symptoms", Scand J Urol Nephrol, 41, pp.521~526 (2007)
- Cartwright R, "Is there seasonal variation in symptom severity, uroflowmetry and frequency-volume chart parameters in men with lower urinary tract symptoms?", Scott Med J, 59, pp.162~166 (2014)
- 최호철, "Seasonal Variation of Urinary Symptoms in Korean Men with Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia", The World Journal of Men's Health, 33(2), pp.81~87 (2015), 대한남성과학회
- Minami J, "Seasonal variations in office and home blood pressures in hypertensive patients treated with antihypertensive drugs", Blood Press Monit, 3, pp.101~106 (1998)
- Hanazawa T, "Seasonal variation in self-measured home blood pressure among patients on antihypertensive medications : HOMED-BP study", Hypertens Res, 40, pp.284~290 (2017)
- Yoshimura K, "Fluctuation of night time frequency in patients with symptomatic nocturia", Int J Urol, 12, pp.469~473 (2005)
- Imamura T, "Cold environmental stress induces detrusor overactivity via resiniferatoxin-sensitive nerves in conscious rats", Neurourol Urodyn, 27, pp.348~352 (2008)
- Chen Z, "Role of alpha1-adrenergic receptors in detrusor overactivity induced by cold stress in conscious rats", Neurourol Urodyn, 28, pp.251~256 (2009)
- Kohn D, "Why does cold weather cause frequency of micturition in some elderly people?", Br Med J, 281, pp.875~ (1980)
- Stocks JM, "Human physiological responses to cold exposure", Aviat Space Environ Med, 75, pp.444~457 (2004)
- Hassi J, "Plasma levels of endothelin-1 and atrial natriuretic peptide in men during a 2-hour stay in a cold room", Acta Physiol Scand, 142, pp.481~485 (1991)
- Bosch JL, "The International Prostate Symptom Score in a community-based sample of men between 55 and 74 years of age: prevalence and correlation of symptoms with age, prostate volume, flow rate and residual urine volume", Br J Urol, 75, pp.622~630 (1995)
- Rosier PF, "Clinical diagnosis of bladder outlet obstruction in patients with benign prostatic enlargement and lower urinary tract symptoms : development and urodynamic validation of a clinical prostate score for the objective diagnosis of bladder outlet obstruction", J Urol, 155, pp.1649~1654 (1996)
- van Venrooij GE, "The value of symptom score, quality of life score, maximal urinary flow rate, residual volume and prostate size for the diagnosis of obstructive benign prostatic hyperplasia: a urodynamic analysis", J Urol, 155, pp.2014~2018 (1996)
- Wadie BS, "The relationship of the International Prostate Symptom Score and objective parameters for diagnosing bladder outlet obstruction. Part I: when statistics fail", J Urol, 165, pp.32~34 (2001)
- Porru D, "Relationship of flow rate with symptoms, quality of life and other clinical parameters in patients with LUTS suggestive of BPH", Eur Urol, 40(Suppl 1), pp.23~27 (2001)
- Vesely S, "Relationship between age, prostate volume, prostate-specific antigen, symptom score and uroflowmetry in men with lower urinary tract symptoms", Scand J Urol Nephrol, 37, pp.322~328 (2003)
- Itoh H, "Significant relationship of time-dependent uroflowmetric parameters to lower urinary tract symptoms as measured by the International Prostate Symptom Score", Int J Urol, 13, pp.1058~1065 (2006)
- Singla S, "Experience with uroflowmetry in evaluation of lower urinary tract symptoms in patients with benign prostatic hyperplasia", J Clin Diagn Res, 8, pp.NC01~NC3 (2014)
- van Haarst EP, "The international prostate symptom score overestimates nocturia assessed by frequency-volume charts", J Urol, 188, pp.211~215 (2012)
- Morita T, "Involvement of magnitude of ambient temperature change in nonspecific effect in perceived placebo effect on lower urinary tract symptoms : study on switching of naftopidil in patients with benign prostatic hyperplasia", Res Rep Urol, 5, pp.83~90 (2013)