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Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome

Karl-Erik Andersson|Lori Birder
대한배뇨장애요실금학회 (Korean Continence Society)|2018.10|International Neurourology Journal|제22권 제1호|pp. 3-9

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키워드

StressInflammationInterstitial cystitisBladder pain syndromeAnimal modelsMucosa

초록

The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment.

Abstract

The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment.

참고문헌 (56)

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관련 논문AI추천

Animal Model of Interstitial Cystitis/Bladder Pain Syndrome권휘안대한배뇨장애요실금학회 · International Neurourology Journal2018 · 제22권 제1호Comparison of 5 Different Rat Models to Establish a Standard Animal Model for Research Into Interstitial Cystitis권태균, 김대환, 김범수, 김연용, 김정식, 송필현, 유은상, 이준녕, 이효정, 전소영, 정재욱, 하윤석대한배뇨장애요실금학회 · International Neurourology Journal2017 · 제21권 제3호Current Understanding and Future Perspectives of Interstitial Cystitis/Bladder Pain SyndromeJane M. Meijlink, Naoki Yoshimura, Philip M. Hanno, Ryoichi Saito, Tomohiro Ueda대한배뇨장애요실금학회 · International Neurourology Journal2021 · 제25권 제2호Potential Mechanisms Underlying the Increased Excitability of the Bladder Afferent Pathways in Interstitial Cystitis/Bladder Pain Syndrome김두상대한요로생식기감염학회 · Urogenital Tract Infection2018 · 제13권 제2호Urodynamic Findings in an Awake Chemical Cystitis Rat Model Observed by Simultaneous Registrations of Intravesical and Intraabdominal Pressures이택, 권용현, 박창신, 신화연, 윤상민, 진롱후대한배뇨장애요실금학회 · International Neurourology Journal2010 · 제14권 제1호Pathomechanism of Interstitial Cystitis/Bladder Pain Syndrome and Mapping the Heterogeneity of DiseaseHann-Chorng Kuo, Jia-Fong Jhang대한배뇨장애요실금학회 · International Neurourology Journal2016 · 제20권 제1호

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