Lower Urinary Tract Symptoms in Elderly Population With Multiple Sclerosis
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: The aim of this study is to compare the clinical and urodynamic characteristics of urinary disorders in multiple sclerosis (MS) patients in a geriatric population with a nongeriatric population. Methods: This study was conducted retrospectively between 2010 and 2016. Each patient with MS aged 65 and older was matched with 2 patients with MS aged less than 65 in sex, form of MS, and Expended Disability Status Scale (EDSS). Demographic data, urinary symptoms, treatment, quality of life, repercussion of lower urinary tract symptoms on daily life activities and psychological state and urodynamic parameters were collected. Differences between the 2 populations were evaluated using Student test, chi-square, or Fischer tests. Results: Twenty-four patients with MS aged 65 and older (mean age, 69.8 years) were matched with 48 patients aged less than 65 years (mean age, 49.4 years). Maximum urethral closure pressure was lower in the elderly population than in the nongeriatric population (mean±standard deviation [SD]: 35.6±18.5 cm H2O vs. 78.2±52.3 cm H2O, P<0.001). In the male population, there was no statistical difference in any other clinical or urodynamic endpoints. In the female population, voiding symptoms was more described in the nongeriatric population (Urinary Symptom Profile low stream: 3.4±3.5 vs. 1.7±2.4, P=0.04), geriatric population had less urinary treatment (P=0.05). LUTS had less impact on quality of life (Qualiveen: 1.4±1.0 vs. 2.1±0.9, P=0.02) on the geriatric population than in the nongeriatric of female MS patients. Conclusions: Geriatric population of MS has few differences of urinary disorders compared to a nongeriatric population with EDSS, sex, and MS form equal. However, the psychological impact of these urinary disorders is less important in female geriatric population.
Abstract
Purpose: The aim of this study is to compare the clinical and urodynamic characteristics of urinary disorders in multiple sclerosis (MS) patients in a geriatric population with a nongeriatric population. Methods: This study was conducted retrospectively between 2010 and 2016. Each patient with MS aged 65 and older was matched with 2 patients with MS aged less than 65 in sex, form of MS, and Expended Disability Status Scale (EDSS). Demographic data, urinary symptoms, treatment, quality of life, repercussion of lower urinary tract symptoms on daily life activities and psychological state and urodynamic parameters were collected. Differences between the 2 populations were evaluated using Student test, chi-square, or Fischer tests. Results: Twenty-four patients with MS aged 65 and older (mean age, 69.8 years) were matched with 48 patients aged less than 65 years (mean age, 49.4 years). Maximum urethral closure pressure was lower in the elderly population than in the nongeriatric population (mean±standard deviation [SD]: 35.6±18.5 cm H2O vs. 78.2±52.3 cm H2O, P<0.001). In the male population, there was no statistical difference in any other clinical or urodynamic endpoints. In the female population, voiding symptoms was more described in the nongeriatric population (Urinary Symptom Profile low stream: 3.4±3.5 vs. 1.7±2.4, P=0.04), geriatric population had less urinary treatment (P=0.05). LUTS had less impact on quality of life (Qualiveen: 1.4±1.0 vs. 2.1±0.9, P=0.02) on the geriatric population than in the nongeriatric of female MS patients. Conclusions: Geriatric population of MS has few differences of urinary disorders compared to a nongeriatric population with EDSS, sex, and MS form equal. However, the psychological impact of these urinary disorders is less important in female geriatric population.
참고문헌 (26)
- Leray E, "Excess mortality in patients with multiple sclerosis starts at 20 years from clinical onset: data from a large-scale French observational study", PLoS One, 10, pp.e0132033~ (2015)[DOI]
- Buhse M, "The elderly person with multiple sclerosis: clinical implications for the increasing life-span", J Neurosci Nurs, 47, pp.333~339 (2015)[DOI]
- Stern M, "Aging with multiple sclerosis", Phys Med Rehabil Clin N Am, 16, pp.219~234 (2005)[DOI]
- Wiedemann A, "Which clinical risk factors determine a pathological urodynamic evaluation in patients with multiple sclerosis? an analysis of 100 prospective cases", World J Urol, 31, pp.229~233 (2013)[DOI]
- Wang T, "Clinical characteristics and urodynamic analysis of urinary dysfunction in multiple sclerosis", Chin Med J (Engl), 129, pp.645~650 (2016)[DOI]
- Ruffion A, "Systematic review of the epidemiology of urinary incontinence and detrusor overactivity among patients with neurogenic overactive bladder", Neuroepidemiology, 41, pp.146~155 (2013)[DOI]
- DuBeau CE, "Incontinence in the frail elderly: report from the 4th International Consultation on Incontinence", Neurourol Urodyn, 29, pp.165~178 (2010)[DOI]
- 정하범, "A current perspective on geriatric lower urinary tract dysfunction", Investigative and Clinical Urology, 56(4), pp.266~275 (2015), 대한비뇨의학회
- Wagg A, "Urinary incontinence in frail elderly persons: report from the 5th International Consultation on Incontinence", Neurourol Urodyn, 34, pp.398~406 (2015)[DOI]
- McGrother CW, "Urinary storage symptoms and comorbidities: a prospective population cohort study in middle-aged and older women", Age Ageing, 35, pp.16~24 (2006)[DOI]
- Sliwa JA, "Upper urinary tract abnormalities in multiple sclerosis patients with urinary symptoms", Arch Phys Med Rehabil, 77, pp.247~251 (1996)[DOI]
- Koldewijn EL, "Relationship between lower urinary tract abnormalities and disease-related parameters in multiple sclerosis", J Urol, 154, pp.169~173 (1995)[DOI]
- Giannantoni A, "Urological dysfunctions and upper urinary tract involvement in multiple sclerosis patients", Neurourol Urodyn, 17, pp.89~98 (1998)[DOI]
- Mayo ME, "Lower urinary tract dysfunction in multiple sclerosis", Urology, 39, pp.67~70 (1992)[DOI]
- Sand PK, "The diagnosis and management of lower urinary tract symptoms in multiple sclerosis patients", Dis Mon, 59, pp.261~268 (2013)[DOI]
- Dong G, "Multiple sclerosis increases fracture risk: a meta-analysis", Biomed Res Int, 2015, pp.650138~ (2015)
- Haab F, "Comprehensive evaluation of bladder and urethral dysfunction symptoms: development and psychometric validation of the Urinary Symptom Profile (USP) questionnaire", Urology, 71, pp.646~656 (2008)[DOI]
- Costa P, "Quality of life in spinal cord injury patients with urinary difficulties. Development and validation of qualiveen", Eur Urol, 39, pp.107~113 (2001)[DOI]
- Bonniaud V, "Qualiveen: a urinary disorder-specific instrument for use in clinical trials in multiple sclerosis", Arch Phys Med Rehabil, 87, pp.1661~1663 (2006)[DOI]
- Abrams P, "The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society", Neurourol Urodyn, 21, pp.167~178 (2002)[DOI]
- Schafer W, "Good urodynamic practices: uroflowmetry, filling cystometry, and pressure-flow studies", Neurourol Urodyn, 21, pp.261~274 (2002)[DOI]
- Lose G, "Standardisation of urethral pressure measurement: report from the Standardisation Sub-Committee of the International Continence Society", Neurourol Urodyn, 21, pp.258~260 (2002)[DOI]
- Hannestad YS, "Epidemiology of Incontinence in the County of Nord-Trondelag. A community-based epidemiological survey of female urinary incontinence: the Norwegian EPINCONT study. Epidemiology of Incontinence in the County of Nord-Trondelag", J Clin Epidemiol, 53, pp.1150~1157 (2000)[DOI]
- Pfisterer MH, "The effect of age on lower urinary tract function: a study in women", J Am Geriatr Soc, 54, pp.405~412 (2006)[DOI]
- Osman NI, "Evaluation and classification of stress urinary incontinence: current concepts and future directions", Eur Urol Focus, 2, pp.238~244 (2016)[DOI]
- Wagg A, "Incontinence", pp.1309~1442 (2016), International Consultation on Incontinence