뇌경색 위험인자로서의 혈중 지질에 대한 임상적 연구
A Clinical Study on Blood Lipids as a Risk Factor of Cerebral Infarction
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Objects : The purpose of this case-control study was done to examine the relationship among the acute brain infarction, silent brain infarction and blood lipids. Methods : We compared the components of blood lipids among acute brain infarction patients group (n=99), silent brain infarction patients group(n=101) and controls group (n=153). The analysis of the data was done by Frequency Analysis, one-way ANOVA, Post Hoc Test(Duncan), Pearson's Correlation. Results : The results were as follows. High density lipoprotein cholesterol(HDL-Chol) was significantly lower in patients of acute brain infarctions group. The blood levels of total cholesterol(T-Chol) was significantly higher in patients of silent brain infarctions. A study on the relationship among the significant variables ; In T-Chol and HDL-Chol, DM(No=0, Yes=1) and Age, they had positive correlation each other. Between Sex(Female=0, Male=1) and HDL-Chol, Age and HDL-Chol, DM and HDL-Chol, they had negative correlation each other. Conclusions : These results suggest that low HDL-Chol may be risk factor of acute brain infarction.
Abstract
Objects : The purpose of this case-control study was done to examine the relationship among the acute brain infarction, silent brain infarction and blood lipids. Methods : We compared the components of blood lipids among acute brain infarction patients group (n=99), silent brain infarction patients group(n=101) and controls group (n=153). The analysis of the data was done by Frequency Analysis, one-way ANOVA, Post Hoc Test(Duncan), Pearson's Correlation. Results : The results were as follows. High density lipoprotein cholesterol(HDL-Chol) was significantly lower in patients of acute brain infarctions group. The blood levels of total cholesterol(T-Chol) was significantly higher in patients of silent brain infarctions. A study on the relationship among the significant variables ; In T-Chol and HDL-Chol, DM(No=0, Yes=1) and Age, they had positive correlation each other. Between Sex(Female=0, Male=1) and HDL-Chol, Age and HDL-Chol, DM and HDL-Chol, they had negative correlation each other. Conclusions : These results suggest that low HDL-Chol may be risk factor of acute brain infarction.
참고문헌 (40)
- Anual report on the cause of death statistics, "Korean National Statistical Office", ~ (2006)
- 김영석, "임상중풍학" (1997), 서원당
- Whisnant JP., "Modelling of risk factors for ischemic stroke", Willis Lecture. Stroke, 28, pp.1840~1844 (1997)
- Van Hinsbergh VW., "Arteriosclerosis. impairment of cellular interactions in the arterial wall", Ann NY Acad. Scie, 673, pp.321~330 (1992)
- Caplan LR., "Silent brain infarcts", Cerebrovascular Dis, 4, pp.32~39 (1994)
- Herderschee D., "Silent stroke in patients with transient ischemic attack or minor ischemic stroke. The Dutch TIA Trial Study Group", Stroke, 23(9), pp.1220~1224 (1992)
- 부송아, "뇌졸중의 위험요인에 대한 환자-대조군 연구-과거병력, 생활습관, 혈청지질 및 비만 요인을 중심으로-", 대한한방내과학회지, 22(3), pp.423~430 (2001)
- 이현의, "뇌졸중의 위험지표로서의 일반혈액검사 소견에 대한 환자-대조군 연구", 대한한방내과학회지, 28(4), pp.872~885 (2007)
- 조길우, "뇌경색증과 심근경색환자에서 죽상동맥경화 위험요인의 비교 연구", 대한내과학회지, 41(4), pp.469~480 (1991)
- 백혜기, "무증상 뇌경색의 위험요인에 대한 환자 - 대조군 연구", 대한한방내과학회지, 28(4), pp.850~862 (2007), 대한한방내과학회
- 이원로, "심장학. 제1판", pp.748~ (1998), 고려의학
- American Diabetes Association, "Report of the expert committee on the Diagnosis and clsssification of Diabetes Mellitus", Diabetes Care, 20, pp.1183~1197 (1997)
- 경희의료원 한방병원 제2내과학교실, "오늘의 한방중풍치료", pp.15~20 (2004), 서원당
- 한기훈, "2002 내과학의 최신지견Ⅴ(고지혈증의 진단 및 치료에 대한 접근)", pp.125~137 (2002), 울산의대 서울아산병원 내과
- "NHANES(National Health and Nutrition Examination Survey) Ⅲ", ~ (1988)
- 방혜정, "고지혈증에 대한 한의학적 고찰", 동서의학, 20(1), pp.25~36 (1985)
- 탁양주, "혈청 총콜레스테롤과 관련된 인자들", 가정의학회지, 13(12), pp.935~942 (1992)
- Isselbacher KJ., "Principle of internal medicine. Harrison. 13thed", pp.1106~1116 (1994), McGraw Hill
- Prospective studies collaboration, "cholesterol, diastolic blood pressure, and stroke; 13,000 strokes in 450,000 people in 45 prospective cohorts", Lancet, 346, pp.1647~1653 (1995)
- Amarenco P., "Hypercholesterolemia, lipid-lowering agents, and the risk for brain infarction", Neurology, 57(5), pp.35~44 (2001)
- Iso H., "Cohen JD for the MRFIT Research Group. Serum cholesterol levels and six-year mortality from stroke in 35,977 men screened for the multiple risk factor intervention trial", N Engl J Med, 320, pp.904~910 (1989)
- Shahar E., "Plasma lipid profile and incident ischemic stroke", The Atherosclerosis Risk in Communities (ARIC) Study. Stroke, 34(3), pp.623~631 (2003)
- Chodosh EH., "Silent stroke in the NINCDS Stroke Data Bank", Neurology, 38, pp.1674~1679 (1988)
- Kase CS., "Prevalence of silent stroke in pationts presenting with intial stroke: The Framingham Study", Strok, 20, pp.850~852 (1989)
- Yoon SK., "Silent brain infarcts in first-ever ischemic stroke pations; MRI findings and stroke risk factors", J Korean Neurol Assoc, 14, pp.42~45 (1996)
- Vermeer SE., "Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study", Stroke, 33, pp.21~25 (2002)
- WHO Western Pacific Region, "International Association for the Study of Obesty, International Obesty Task Force. The Asia-Pacific perspective; redefining obesty and its treatment" (2000), Health Communications
- 신건민, "뇌졸중의 위험인자에 관한 조사", 대한신경과학회지, 6(2), pp.218~227 (1988)
- 위봉애, "뇌혈전증 환자에서의 혈청지질에 대한 조사", 대한신경과학회지, 7(2), pp.258~265 (1989)
- Choi-Kwon S., "Nutritional status in acute stroke; undernutrition versus overnutrition in different stroke subtypes", Acta Neurol Scand, 98, pp.187~192 (1998)
- Lindenstrom L., "Influence of total cholesterol, high density lipoprotein cholesterol, and triglycerdes on risk of cerebrovascular disease: The Copenhagen City Heart", Study. BMJ, 309, pp.11~15 (1994)
- Juan PB., "Lipoprotein and apolipoprotein profile in men with ischemic stroke", Stroke, 23(11), pp.1556~1562 (1992)
- Rhoads GA., "Serum triglyceride and risk of coronary heart disease, stroke and total mortality in Japanese-American men", Atherosclerosis, 3, pp.316~322 (1983)
- Miller GJ., "Plasma-high-density lipoprotein concentration and development of ischemic heart disease", Lancet, 1, pp.16~19 (1975)
- 박영배, "정상인 및 각종질환에서의 혈청지질에 관한 연구: HDL Cholesterol을 중심으로", 순환기, 11(1), pp.55~68 (1981)
- Gordon T., "Lipoprotein; cardiovascular disease and death: The Framingham Study", Arch Inter Med, 141, pp.1128~1135 (1981)
- Brown G., "Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B", N Engl J Medl, 323(19), pp.1289~1298 (1990)
- 이선우, "중풍 환자의 사상체질 유형별 혈중지질 분포에 대한 상관성 연구", 대한한방내과학회지, 27(2), pp.488~499 (2006), 대한한방내과학회
- Woo J., "Acute and long-term changes in serum lipids after acute stroke", Stroke, 21, pp.1407~1411 (1990)
- Ivar M., "Serum lipids after stroke", Neurology, 37, pp.501~511 (1987)
