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Effects of Atractylodis Rhizoma Pharmacopuncture on an Acute Gastric Mucosal Lesion Induced by Compound 48/80 in Rats

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Objectives: This study was designed to investigate the protective effects of Atractylodis Rhizoma pharmacopuncture (ARP) against acute gastric mucosal lesions induced by compound 48/80 in rats. Methods: The ARP was injected in Joksamni (ST36) and Jungwan (CV12) 1 hr before treatment with compound 48/80. The animals were sacrificed under anesthesia 3 hrs after treatment with compound 48/80. The stomachs were removed, and the amounts of gastric adherent mucus, gastric mucosal hexosamine, thiobarbituric acid reactive substances (TBARS),xanthine oxidase (XO), and superoxide dismutase (SOD) were measured. Also, histological examination were performed. Results: Gastric adherent mucus, gastric mucosal hexosamine and histological defects of gastric mucosa declined significantly after ARP treatment. Changes in gastric mucosal TBARS were also reduced by ARP treatment, but this result was not statistically significant. ARP treatment did not change the XO and the SOD activities. Conclusions: ARP showed protective effects for acute gastric mucosal lesions induced by compound 48/80 in rats. These results suggest that ARP may have protective effects for gastritis.

Abstract

Objectives: This study was designed to investigate the protective effects of Atractylodis Rhizoma pharmacopuncture (ARP) against acute gastric mucosal lesions induced by compound 48/80 in rats. Methods: The ARP was injected in Joksamni (ST36) and Jungwan (CV12) 1 hr before treatment with compound 48/80. The animals were sacrificed under anesthesia 3 hrs after treatment with compound 48/80. The stomachs were removed, and the amounts of gastric adherent mucus, gastric mucosal hexosamine, thiobarbituric acid reactive substances (TBARS),xanthine oxidase (XO), and superoxide dismutase (SOD) were measured. Also, histological examination were performed. Results: Gastric adherent mucus, gastric mucosal hexosamine and histological defects of gastric mucosa declined significantly after ARP treatment. Changes in gastric mucosal TBARS were also reduced by ARP treatment, but this result was not statistically significant. ARP treatment did not change the XO and the SOD activities. Conclusions: ARP showed protective effects for acute gastric mucosal lesions induced by compound 48/80 in rats. These results suggest that ARP may have protective effects for gastritis.

참고문헌 (26)

  1. Lee EL., "Gastritis and other gastropathies, In Sleigenger & Fordtran's gastrointestinal and liver disease, 7th ed", pp.810~827 (2002), WB Saunders Company
  2. Cho SY., "Antigastric effect of carbenoxolone disodium from glycyrrhizae radix", J Toxical Pub Health, 23(2), pp.165~172 (2007)
  3. Kim IR., "Boncho-Hak", pp.331~332 (2007), Young-Lim Press
  4. Enerba. . ck L., "Ultrastructure of mucosal mast cells in normal and compound 48-80-treated rats", Cell Tissue Res, 150(1), pp.95~105 (1974)
  5. Irman-Florjanc T., "Compound 48", 80 and substance P-induced release of histamine and serotonin from rat peritoneal mast cells, 1983, pp.13(2-3)), 138~141
  6. 이혜림, "Selectively Decreased Expression of Peroxiredoxins Induced by Silica in Pulmonary Epithelial Cells", The Korean Journal of Internal Medicine, 24(3), pp.220~226 (2009), 대한내과학회
  7. 김재열, "패혈증과 항산화제", 대한중환자의학회지, 25(2), pp.57~60 (2010), 대한중환자의학회
  8. Grisham MB., "Interaction between oxygen radicals and gastric mucin. Am J Physiol", Gastrointestinal and Liver Physiology., 253(1), pp.G93~96 (1987)
  9. Yu KW., "Identification of Pectic Polysaccharide Possessing Bone Marrow Cell Proliferation Activity through Peyer’s Patch Cells from rhizomes of Atractylodes lancea DC", Food Sci Biotechnol, 10(4), pp.437~445 (2001)
  10. Li CQ., "Atractylenolide I and atractylenolide Ⅲ inhibit lipopolysaccharide-induced TNF-alpha and NO production in macrophages", Phytother Res, 21(4), pp.347~353 (2007)
  11. Prieto JM., "Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions", J Pharm Pharmacol, 55(9), pp.1275~1282 (2003)
  12. Kim DY., "The effects of Jung-wan(CV12)and Wi-su(B21)aqua-acupuncture with Atractylodis Rhizoma extract in gastritis", The journal of Korean acupuncture & moxibustion society, 10(1), pp.289~296 (1993)
  13. Tian L., "Downregulation of electroacupuncture at ST36 on TNF-alpha in rats with ulcerative colitis", World J Gastroenterol, 9(5), pp.1028~1033 (2003)
  14. Chang SL., "An insulin-dependent hypoglycaemia induced by electroacupuncture at the Zhongwan(CV12)acupoint in diabetic rats", Diabetologia, 42(2), pp.250~255 (1999)
  15. Kitagawa H., "A simple method for estimation of gastric mucus and effects of antiulcerogenic agents on the decrease in mucus during water-immersion stress in rats", Arzneimittelforschung, 36(8), pp.1240~1244 (1986)
  16. 김형민, "The regulatory mechanism of β-eudesmol is through the suppression of caspase-1 activation in mast cell-mediated inflammatory response", Immunopharmacology and Immunotoxicology, 33(1), pp.178~185, Marcel Dekker Inc.
  17. Kamada T., "Effect of long-term half-dose famotidine therapy on corpus gastritis in peptic ulcer disease", Aliment Pharmacol Ther., 21(Suppl s2), pp.99~104 (2005)
  18. Ohta Y., "Plaunotol prevents the progression of acute gastric mucosal lesions induced by compound 48", 80, a mast cell degranulator, in rats, 2005, pp.74(4), 182~192
  19. Ohta Y., "Protective effect of teprenone against acute gastric mucosal lesions induced by compound 48", 80, a mast cell degranulator, in rats, 2003, pp.93(3), 337~346
  20. Joo JH., "Dangaesimbub", pp.503~509 (1982), Dae Sung Publishing Company
  21. Moriga M., "The role of gastric mucosal hexosamine in aspirin-induced ulcers", Gastroenterol Jpn, 15(1), pp.1~6 (1980)
  22. Katsurahara M., "Reactive nitrogen species mediate DNA damage in Helicobacter pylori-infected gastric mucosa", Helicobacter, 14(6), pp.552~558 (2009)
  23. Yazici I., "Salinity tolerance of purslane(Portulaca oleracea L. )is achieved by enhanced antioxidative system, lower level of lipid peroxidation and proline accumulation", Environ Exp Bot, 61(1), pp.49~57 (2007)
  24. 권강, "蚯蚓藥鍼이 비만쥐의 지질강하능, 항산화능, 전염증성 Cytokines 농도에 미치는 영향", 대한침구의학회지, 27(2), pp.59~69 (2010), 대한침구의학회
  25. 정영옥, "통풍의 최신지견", 대한내과학회지, 76(5), pp.538~543 (2009), 대한내과학회
  26. 신정수, "七氣湯 藥鍼液이 활성산소종, 활성질소종, 지질과산화 및 LDL의 산화에 미치는 영향", Korean Journal of Acupuncture, 25(4), pp.89~104 (2008), 경락경혈학회

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