대사증후군에서 남성 하부요로증상 관련 위험요인 분석
Analysis of risk factors associated with male lower urinary tract symptoms in the metabolic syndrome
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Abstract
Puropose: The purpose of this study was to evaluate the relationship between lower urinary tract symptoms (LUTS) and the metabolic syndrome in the elderly male. Material and methods: The metabolic syndrome group of 348 patients (64.4±8.6 years old) and the control group of 150 patients (66.0±7.0 years old) were included in the study. The voiding factors, such as International Prostate Symptom Score (IPSS), quality of life score, prostate volume, maximal urine flow rate, residual urine volume, and prostate-specific antigen (PSA) were investigated. Waist circumference, blood pressure, fasting glucose, HDL-cholesterol, triglyceride were measured for the evaluation of the metabolic syndrome. Results: Waist circumference (β=0.025, p<0.001), systolic (β=0.004, p<0.05) and diastolic blood pressure (β=0.006, p<0.05) were positively correlated with prostate volume. In the logistic regression analysis of voiding factors according to metabolic syndrome factors, the patients who have central obesity (Odds ratio [OR]=2.931), central obesity and hypertension (OR=3.598), central obesity and diabetes (OR=2.508), hypertension and low HDL-cholesterolemia (OR=2.326), central obesity, hypertension and diabetes (OR=3.083), central obesity, hypertension and low HDL cholesterolemia (OR=3.440) represented a significantly increased age-adjusted risk of benign prostatic enlargement (25g or more). OR of symptomatic benign prostatic hyperplasia (BPH) was 3.178 in the patients with cental obesity, and 2.381 in the patients with both central obesity and hypertension. Conclusions: In male elderly, the metabolic syndrome was closely related with LUTS and its main risk factor was central obesity, represented as waist circumference. (J Korean Continence Soc 2008;12:27-35)
참고문헌 (24)
- 2000 Annual report on the cause of death statistics, "Korea National Statistical Office", ~ (2001)
- Wilson PW., "Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories", Circulation, 97, pp.1837~1847 (1998)
- Fluster V., "17th Nethesda 27th Bethesda Conference. Matching the intensity of risk factor management with the hazard for coronary heart disease events", J Am Coll Cardiol, 27, pp.957~1047 (1996)
- Reaven GM, "Banting lecture 1988. Role of the insulin resistance in human disease", Diabetes, 37, pp.1595~1607 (1988)
- DeFronzo RA, "Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease", Diabetes Care, 14, pp.173~194 (1991)
- Hellmich M., "Development and validation of a risk score for somatic erectile dysfunction: combined results from three cross-sectional surveys", Eur Urol, 48, pp.495~502 (2005)
- 김재헌, "전립선비대증에서 대사증후군 관련요인 분석", 대한비뇨기과학회지, 46(10), pp.1046~1050 (2005), 대한비뇨기과학회
- Hedblad B., "Insulin resistance in non-diabetic subjects is associated with increased incidence of myocardial infarction and death", Diabet Med, 19, pp.470~5 (2002)
- Meigs JB., "Epidemiology of the metabolic syndrome, 2002", Am J Manag Care, 8(11), pp.S283~92 (2002)
- Lakka HM., "The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men", JAMA, 288, pp.2709~2716 (2002)
- Kwon HS, "Update on the metabolic syndrome", Biowave, 9, pp.1~12 (2007)
- "The IDF consensus worldwide definition of the metabolic syndrome"[URL]
- Nugent AP, "The metabolic syndrome", Nutr Bull, 29, pp.36~43 (2004)
- 임열리, "ATP Ⅲ의 진단기준에 따른 대사증후군의 유병률과 관련위험요인 분석-일개 대학병원 건강증진센터 수진자를 대상으로", 가정의학회지, 24(02), pp.135~43 (2003)
- Rett K., "New aspects of insulin resistance in hypertension", Eur Heart J, 15, pp.78~81 (1994)
- Landsberg L. Diet, "obesity and hypertension: an hypothesis involving insulin, the sympathetic nervous system, and adaptive thermogenesis", Q J Med, 61, pp.1081~90 (1986)
- Berne C, "The sympathetic outflow in vasoconstrictor nerve fascicles to muscle is increased during euglycacemic hyperinsulinemia", Diabetologia, 32, pp.465A~ (1989)
- Zaroli A., "Antonelli D, Bernasconi S, Buizza C, et al. Physiopathology of BPH obstruction", Arch Ital Urol Androl, 67, pp.13~6 (1995)
- Dahle SE, "Body size and serum levels of insulin and leptin in relation to the risk of benign prostatic hyperplasia", J Urol, 168, pp.599~604 (2002)
- Sugaya K., "hypertension on lower urinary tract symptoms in benign prostatic hyperplasia", Int J Urol, 10, pp.569~74 (2003)
- 최영호, "춘천 지역 중년 및 노인에서의 대사증후군의 유병률과 관련위험요인: 한림노년연구", 가정의학회지, 27(3), pp.190~200 (2006), 대한가정의학회
- Saito M., "Effect of ageing on blood flow to the bladder and bladder function", Urol Int, 62, pp.93~8 (1999)
- Saito M., "Effect of ageing on blood flow to the bladder and bladder function", Urol Int, 62, pp.93~8 (1999)
- Ozden C, "The Correlation between metabolic syndrome and prostatic growth in patients with benign prostatic hyperplasia", Eur Urol, 51, pp.199~203 (2007)