黃 湯加味方이 出産 後 생쥐 및 흰쥐의 免疫反應과 造血機能에 미치는 影響
The Effect of Hwangkitang-gamibang on Immune Response and Blood Formation in a Delivered Murine Model
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Abstract
The purpose of this research was to investigate the effects of Hwangkitang (HKT) on the immune response and blood formation in a delivered-murine model. HKT (500mg/kg) was administerd p.o. once a day for 7 days. HKT decreased the cell viability of thymocytes in vivo and in vitro system, but increased the cell viability of splenocytes in delivered mice. HKT enhanced the population of helper T (Th) cells and decreased the population of cytotoxic T (Tc) cells in thymocytes. In addition, HKT decreased the population of B-lymphocytes in splenocytes. Also, HKT enhanced the production of -interferon and interleukin-2 in splenocytes. HKT increased the production of nitric oxide in vivo, but did not affect the production of nitric oxide in vitro system. Furthermore, HKT enhanced the phagocytic activity of peritoneal macrophages in vivo and in vitro. HKT partly recovered the level of RBC and hemoglobin decreased by phenylhydrazine at 10 days. These results suggest that HKT increase the specific immune response via enhancement of the viability of splenocytes and the non-specific immunity via enhancement of phagocytic activity of peritoneal macrophages and recover the number of RBC and the volume of hemoglobin in a delivered murine model.
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