牧丹散의 抗血栓 作用에 대한 實驗的 硏究
The Experimental Study on Antithrombotic Effect of Mokdansan
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Abstract
This study was performed to evaluate antithrombotic action of Mokdansan(MDS) which has effects of activating blood and removing thrombus. The results were obtained as follows MDS significantly inhibited platelet aggregation indu ced by ADP and epinephrine when analyzed by the Sigmoid Emax model in WinNonlin. EC50 values of MDS were 0.16 mg/ml and 15.59 mg/ml for ADP and epinephrine respectively. MDS showed fibrinolytic activity insignificantly as compared with the control group. MDS increased blood flow rate significantly as compared with the control group in vitro, but insignificantly as compared with the control group in vivo. MDS inhibited pulmonary embolism induced by collagen and epinephrine (inhibitive rate 50 %). MDS increased number of platelet, fibrinogen amount and shortened prothrombin time, activated partial thromboplastin time significantly as compared with the control group in thrombus model induced by dextran.
참고문헌 (23)
- "臨床婦産科學", pp.104~107 (1989), 成輔社
- "問答式 婦人小兒科學 編譯", pp.83~87 (1992), 成輔社
- "完譯校註 婦人良方", pp.28~32 (1987), 韓林院
- "韓醫學에서의 瘀血에 대한 槪念", pp.138~140 (1984)
- "東醫學의 客觀化와 東西醫學 病名 統一을 위한 方法", pp.7~15 (1976)
- "少腹逐瘀湯이 抗血栓 및 消炎 鎭痛에 미치는 影響" (1995), 圓光大學校 大學院
- "活絡丹의 抗炎 鎭痛 및 抗血栓 效果에 關한 硏究" (1996), 圓光大學校 大學院
- "身痛逐瘀湯의 抗炎 鎭痛 및 抗血栓效果에 關한 硏究" (1996), 圓光大學校 大學院
- "和血通經散의 抗炎 抗血栓 및 鎭痛效果에 對한 硏究" (1996), 圓光大學校 大學院
- "芎歸湯加味方의 抗血栓效果에 關한 硏究" (1996), 圓光大學校 大學院
- "四物湯 構成藥物이 抗血栓 및 抗 stress 效果에 미치는 影響" (1998), 慶熙大學校 大學院
- "坐宮丹이 抗菌 抗血栓 및 鎭痛作用에 미치는 影響" (2001), 大田大學校 大學院
- "加味生化湯의 抗血栓 및 鎭痛效果에 對한 硏究" (2001), 大田大學校 大學院
- "加味通經湯의 抗血栓 消炎 및 鎭痛作用에 對한 硏究" (2002), 大田大學校 大學院
- "Protective effects of Phellinus linteus on reperfusion of the isolated perfused Guinea pig hearts and anti-platelet aggregation effects of Phellinus linteus", pp.17~25 (1994)
- "Effect of losartan on human platelet activation", 17, pp.447~452 (1999)
- "Quality assurance in hematology", pp.113~145
- "Method to measure in vivo blood fibrinolytic activity with a 125i-fibrin coated aorta loop validated with agents which affect blood fibrinolytic activity", 104(3), pp.223~232 (2001)
- "Effect of cilostazol on platelet aggregation and experimental thrombosis", pp.1144~1149 (1985)
- "Effects of aspirin and nifedipine alone or in combination on mesenteric microcirculation of rats", 17(2), pp.189~192 (1996)
- "Pharmacodynamic activity and antithrombotic efficacy of RPR120844 a novel inhibitor of coagulation factor Xa", 34(6), pp.791~799 (1999)
- "原色最新醫療大百科事典", 20, pp.66~68 (1996), 新太陽社
- "瘀血의 病理에 관한 文獻的 考察", pp.399~406 (1985)