Short Term Effect and Safety of Antidiuretic Hormone in the Patients with Nocturia
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Purpose: To investigate the short-term safety of antidiuretic hormone in elderly patients with nocturnal polyuria, focus on hyponatremia and others electrolytes disturbances and to assess short-term effects on nocturnal urine output and number of nocturnal voids. Methods: Between June 2005 and August 2006, a total of 34 patients with nocturnal polyuria were orally administered 0.2 mg desmopressin tablet at bedtime for two weeks. Serum sodium, others electrolytes, urine sodium and urine osmolarity were assessed in the third days, one week and two weeks after treatment with desmopressin and compared adult group (<65 years of age) with elderly group (≥65 years of age). We assessed the effect of desmopressin using a frequency-volume charts and analysed. Results: In total 34 patients (20 adult, 14 elderly) were analyzed. Desmopressin treatment did not significantly change serum and urine electrolytes include soduim concentration in elderly patients comparied with adult patients. Serum sodium concentration below normal range was recorded in 2 patients in elderly group, but no serious adverse events occurred and recovered without sequelae. The mean number of nocturnal voids decresed (54% reduction) and nocturnal urine output decreased (57% reduction) after using desmopressin. Conclusions: Desmopressin was well tolerated and effective in elderly patients with nocturnal polyuria without clinically significant hyponatremia.
Abstract
Purpose: To investigate the short-term safety of antidiuretic hormone in elderly patients with nocturnal polyuria, focus on hyponatremia and others electrolytes disturbances and to assess short-term effects on nocturnal urine output and number of nocturnal voids. Methods: Between June 2005 and August 2006, a total of 34 patients with nocturnal polyuria were orally administered 0.2 mg desmopressin tablet at bedtime for two weeks. Serum sodium, others electrolytes, urine sodium and urine osmolarity were assessed in the third days, one week and two weeks after treatment with desmopressin and compared adult group (<65 years of age) with elderly group (≥65 years of age). We assessed the effect of desmopressin using a frequency-volume charts and analysed. Results: In total 34 patients (20 adult, 14 elderly) were analyzed. Desmopressin treatment did not significantly change serum and urine electrolytes include soduim concentration in elderly patients comparied with adult patients. Serum sodium concentration below normal range was recorded in 2 patients in elderly group, but no serious adverse events occurred and recovered without sequelae. The mean number of nocturnal voids decresed (54% reduction) and nocturnal urine output decreased (57% reduction) after using desmopressin. Conclusions: Desmopressin was well tolerated and effective in elderly patients with nocturnal polyuria without clinically significant hyponatremia.
참고문헌 (23)
- Chute CG, "The prevalence of prostatism: a population-based survey of urinary symptoms", Urol, 150, pp.85~89 (1993)
- Homma Y, "Urinary symptoms and urodynamics in a normal elderly population", Scand J Urol Nephrol Suppl, 15 (1994)
- Imai K, "Nippon Hinyokika Gakkai Zasshi", Nippon Hinyokika Gakkai Zasshi, 82, pp.1790~1799 (1991)
- Hunsballe JM, "Single dose imipramine reduces nocturnal urine output in patients with nocturnal enuresis and nocturnal polyuria", J Urol, 158(3 Pt 1), pp.830~836 (1997)
- Simonsen O, "The significance of age on symptoms and urodynamic-and cystoscopic findings in benign prostatic hypertrophy", Urol Res, 15, pp.355~358 (1987)
- Weiss JP, "Nocturia", J Urol, 163, pp.5~12 (2000)
- Miller M, "Nocturnal polyuria in older people: pathophysiology and clinical implications", J Am Geriatr Soc, 48, pp.1321~1329 (2000)
- Asplund R, "The nocturnal polyuria syndrome (NPS)", Gen Pharmacol, 26, pp.1203~1209 (1995)
- Mattiasson A, "Efficacy of desmopressin in the treatment of nocturia: a double-blind placebo-controlled study in men", BJU Int, 89, pp.855~862 (2002)
- Weatherall M, "The risk of hyponatremia in older adults using desmopressin for nocturia: a systematic review and meta-analysis", Neurourol Urodyn, 23, pp.302~305 (2004)
- Barker JC, "Nocturia in the elderly", Geromtologist, 28, pp.99~104 (1988)
- Sommer P, "Voiding patterns in men evaluated by a questionnaire survey", Br J Urol, 65, pp.155~160 (1990)
- Kim ET, "The etiology and classification of nocturia in adults", Korean J Urol, 42, pp.1075~1079 (2001)
- Asplund R, "Nocturia in relation to sleep, health, and medical treatment in the elderly", BJU Int, 96(Suppl 1), pp.15~21 (2005)
- Chang SC, "Multifactorial nature of male nocturia", Urology, 67, pp.541~544 (2006)
- Miller M, "Nocturnal polyuria in older people: pathophysiology and clinical implications", J Am Geriatr Soc, 48, pp.1321~1329 (2000)
- Weiss JP, "Evaluation of the etiology of nocturia in men: the nocturia and nocturnal bladder capacity indices", Neurourol Urodyn, 18, pp.559~565 (1999)
- Weiss JP, "Nocturia in adults:etiology and classification", Neurourol Urodyn, 17, pp.467~472 (1998)
- Asplund R, "Nocturia, nocturnal polyuria, and sleep quality in the elderly", J Psychosom Res, 56, pp.517~525 (2004)
- Mattiasson A, "Efficacy of desmopressin in the treatment of nocturia: a double-blind placebo-controlled study in men", BJU Int, 89, pp.855~862 (2002)
- Rembratt A, "Desmopressin in elderly patients with nocturia: short-term safety and effects on urine output,sleep and voiding patterns", BJU Int, 91, pp.642~646 (2003)
- Rembratt A, "Desmopressin treatment in nocturia;an analysis of risk factors for hyponatremia", Neurourol Urodyn, 25, pp.105~109 (2006)
- Chang YL, "Short-term effects of desmopressin on water and electrolyte excretion in adults with nocturnal polyuria", J Urol, 177, pp.2227~2229 (2007)