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A Review on Studies of Marijuana for Alzheimer’s Disease – Focusing on CBD, THC

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Objectives: This study was to discuss the research trend of dementia treatment using cannabis for the purpose of providing the basis of cannabis use for medical purposes in the future. Methods: This study searched publications, which were registered to databases or published by Aug 22, 2019, and targeted the full-text or abstracts of these publications. We selected the final nine studies met all selection criteria. Results: These results implied that the CBD components of cannabis might be useful to treat and prevent AD because CBD components could suppress the main causal factors of AD. Moreover, it was suggested that using CBD and THC together could be more useful than using CBD or THC alone. Conclusion: We hope that there will be a solid foundation to use cannabis for medical use by continuously evaluating the possibility of using cannabis for clinical purposes as a dementia treatment substance and cannabis can be used as a positive too

Abstract

Objectives: This study was to discuss the research trend of dementia treatment using cannabis for the purpose of providing the basis of cannabis use for medical purposes in the future. Methods: This study searched publications, which were registered to databases or published by Aug 22, 2019, and targeted the full-text or abstracts of these publications. We selected the final nine studies met all selection criteria. Results: These results implied that the CBD components of cannabis might be useful to treat and prevent AD because CBD components could suppress the main causal factors of AD. Moreover, it was suggested that using CBD and THC together could be more useful than using CBD or THC alone. Conclusion: We hope that there will be a solid foundation to use cannabis for medical use by continuously evaluating the possibility of using cannabis for clinical purposes as a dementia treatment substance and cannabis can be used as a positive too

참고문헌 (26)

  1. 김가나, "치매 한의진단 평가도구 적용 연구", 동의신경정신과학회지, 25(4), pp.383~388 (2014), 대한한방신경정신과학회
  2. 박미선, "치매의 변증 연구", 동의생리병리학회지, 28(3), pp.251~262 (2014), 한의병리학회
  3. 한다영, "알츠하이머병 유발 동물모델에서 한약제재 경구투여가 기억에 미치는 영향에 대한 국내 연구보고 고찰", 동의신경정신과학회지, 28(4), pp.359~371 (2017), 대한한방신경정신과학회
  4. M. Goedert, "A Century of Alzheimer's Disease", Science, 314(5800), pp.777~781 (2006), American Association for the Advancement of Science (AAAS)[DOI]
  5. T. Oide, "Regression stage senile plaques in the natural course of Alzheimer's disease", Neuropathology and Applied Neurobiology, 32(5), pp.539~556 (2006), Wiley[DOI]
  6. Amir Qaseem, "Current Pharmacologic Treatment of Dementia: A Clinical Practice Guideline from the American College of Physicians and the American Academy of Family Physicians", Annals of Internal Medicine, 148(5), pp.370~ (2008), American College of Physicians[DOI]
  7. Patricia R, "Medical Marijuana and pain management", Peer-reviewed excellence in life care planning, 19(3), pp.20~25 (2019)[DOI]
  8. Ha SY, "Perception Survey of the Use of Medical Marihuana Targeting Cancer-Patients and each of their Protectors", pp.2018
  9. Won SW, "Medical Cannabis, Why Legalize?" (2017), Saeng-gagbihaeng
  10. Shuso Takeda, "Δ9-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: Possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells", Toxicology, 326, pp.18~24 (2014), Elsevier BV[DOI]
  11. Serena Deiana, "Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour", Psychopharmacology, 219(3), pp.859~873 (2012), Springer Science and Business Media LLC[DOI]
  12. Hong TH, "Medical hemp" (2017), Yeongmun
  13. Denise C. Vidot, "Emerging Issues for our Nation's Health: The Intersection of Marijuana Use and Cardiometabolic Disease Risk", Journal of Addictive Diseases, 33(1), pp.1~8 (2014), Informa UK Limited[DOI]
  14. Teresa Iuvone, "Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells", Journal of Neurochemistry, 89(1), pp.134~141 (2004), Wiley[DOI]
  15. Giuseppe Esposito, "The marijuana component cannabidiol inhibits β-amyloid-induced tau protein hyperphosphorylation through Wnt", β-catenin pathway rescue in PC12 cells, 2006, pp.84(3), 253~258[DOI]
  16. Lisa M. Eubanks, "A Molecular Link between the Active Component of Marijuana and Alzheimer's Disease Pathology", Molecular Pharmaceutics, 3(6), pp.773~777 (2006), American Chemical Society (ACS)[DOI]
  17. Alexandre Vallée, "Effects of cannabidiol interactions with Wnt", β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer's disease, 2017, pp.49(10), 853~866
  18. Caterina Scuderi, "Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5Y APP+ Cells Through PPARγ Involvement", Phytotherapy Research, 28(7), pp.1007~1013 (2014), Wiley[DOI]
  19. G Esposito, "Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression", British Journal of Pharmacology, 151(8), pp.1272~1279 (2007), Wiley[DOI]
  20. Giuseppe Esposito, "Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement", PLoS ONE, 6(12), pp.e28668~ (2011), Public Library of Science (PLoS)[DOI]
  21. Ester Aso, "Cannabis-Based Medicine Reduces Multiple Pathological Processes in AβPP", PS1 Mice, 2014, pp.43(3), 977~991[DOI]
  22. Ester Aso, "Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model", Journal of Alzheimer's Disease, 54(3), pp.903~912 (2016), IOS Press[DOI]
  23. Cleusa Ferri, "Resource utilisation for neuropsychiatric disorders in developing countries:", Social Psychiatry and Psychiatric Epidemiology, 39(3), pp.218~227 (2004), Springer Science and Business Media LLC[DOI]
  24. Seoul National University Hospital, "Nationwide study on the prevalence of dementia in Korea elders" (2008), Ministry for Health, Welfare and Family affairs
  25. The 3rd comprehensive plan for dementia management ('16 ~ '20), "Ministry of Health and Welfare", Ministry of Health and Welfare, ~ (2015)
  26. 조희근, "한약처방을 사용한 치매에 대한 실험연구 동향분석-국내 학위논문을 중심으로-", 한방재활의학과학회지, 24(4), pp.29~40 (2014), 한방재활의학과학회

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