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류마티스 관절염에 있어 종양괴사인자 다형성에 대한 연구

Study on Tumor Necrosis Factor-α Gene Polymorphism in Rheumatoid Arthritis

이봉효|임성철|정태영|이경민|서정철|김경운
대한약침학회 (Korean Pharmacopuncture Institute)|2007.06|Journal of Pharmacopuncture|제10권 제2호|pp. 73-79

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참고문헌

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Abstract

Objective: Tumor necrosis factor-α(TNF-α) is a proinflammatory cytokine involved in the pathogenesis of rheumatoid arthritis. This study was designed to investigate the relation between TNF-α gene polymorphism and rheumatoid arthritis in Korean population.Methods: This study was carried out on 103 rheumatoid arthritis patients who fulfilled the American College of Rheumatology 1987 revised criteria for rheumatoid arthritis and 208 healthy control subjects. Blood samples from all subjects were obtained for DNA extraction. The extracted DNA was amplified by polymerse chain reaction(PCR). PCR products were visualized by 2% agarose gel electrophoresis. We investigated the genotyping of TNF-α by using Pyrosequencing.Results: The genotypes of TNF-α gene were GG, AG and AA. While the distribution of TNF-α polymorphism in control subjects was 92.31%, 7.21%, 0.48% respectively, in rheumatoid arthritis patients was 93.20%, 6.80%, 0.00%(GG, AG, AA). There was no statistical significant allelic frequency difference between control and rheumatoid arthritis groups.Conclusion: We concluded that there was no significant association between TNF-α gene polymorphism and rheumatoid arthritis. However, the findings of this study need to be confirmed in more patients and further studies.

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