淫羊藿이 실험적으로 유발된 갑상선 기능저하증 동물모델에 미치는 영향과 안전성
The Effects of Epimedii Herba on a Hypothyroidism Rat Model induced by PTU(6-Propyl, 2-thiouracil).
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Objectives: The symptoms of hypothyroidism are fatigue, cold intolerance, arthralgia, muscle cramps, dry skin and etc. Although hypothyroidism is a relatively common endocrinical disease, we do have many difficulties treating it effectively. The symptoms of hypothyroidism are similar to those of Yang-deficiency in Oriental medicine. Epimedii Herba is a popular herb that has the effect of tonifying the kidney and strengthening Yang in Oriental medicine. In this study, we investigated the therapeutic effects of Epimedii Herba on a hypothyroidism rat model induced by PTU(6-Propyl, 2-thiouracil). Methods: 24 two-month-old Spargue-Dawley(SD) rats were divided into 4 groups: 1) normal(n=6),2) PTU-induced hypothyroidism control(n=6), 3) hypothyroidism rat treated with Epimedii Herba(n=6), 4) hypothyroidism rat treated with levothyroxine(n=6). PTU was administered for 4weeks, Epimedii Herba and levothyroxine was administered for 2 weeks after PTU was initiated for a total duration of 2 week. At the end of the experiment, blood samples from all the rats were taken from their hearts and were analyzed. Results: In comparison with normal group, the PTU-induced control group significantly showed hypothyroidism with low T3, T4 and high TSH. In Epimedii Herba group, T4 was significantly increased(p<0.05). There was no significant difference in TSH between the Epimedii Herba treatment group and the control group. And no significant differences were observed in biochemical labs and weight between the Epimedii Herba group and the control group. Conclusions: These results suggest that Epimedii Herba could help thyroid cells to produce thyroid hormones. And no significant side effects related with Epimedii Herba were found, suggesting that it is safe to administer. According to these results, Epimedii Herba may be a safe alternative medicine for hypothyroidism.
Abstract
Objectives: The symptoms of hypothyroidism are fatigue, cold intolerance, arthralgia, muscle cramps, dry skin and etc. Although hypothyroidism is a relatively common endocrinical disease, we do have many difficulties treating it effectively. The symptoms of hypothyroidism are similar to those of Yang-deficiency in Oriental medicine. Epimedii Herba is a popular herb that has the effect of tonifying the kidney and strengthening Yang in Oriental medicine. In this study, we investigated the therapeutic effects of Epimedii Herba on a hypothyroidism rat model induced by PTU(6-Propyl, 2-thiouracil). Methods: 24 two-month-old Spargue-Dawley(SD) rats were divided into 4 groups: 1) normal(n=6),2) PTU-induced hypothyroidism control(n=6), 3) hypothyroidism rat treated with Epimedii Herba(n=6), 4) hypothyroidism rat treated with levothyroxine(n=6). PTU was administered for 4weeks, Epimedii Herba and levothyroxine was administered for 2 weeks after PTU was initiated for a total duration of 2 week. At the end of the experiment, blood samples from all the rats were taken from their hearts and were analyzed. Results: In comparison with normal group, the PTU-induced control group significantly showed hypothyroidism with low T3, T4 and high TSH. In Epimedii Herba group, T4 was significantly increased(p<0.05). There was no significant difference in TSH between the Epimedii Herba treatment group and the control group. And no significant differences were observed in biochemical labs and weight between the Epimedii Herba group and the control group. Conclusions: These results suggest that Epimedii Herba could help thyroid cells to produce thyroid hormones. And no significant side effects related with Epimedii Herba were found, suggesting that it is safe to administer. According to these results, Epimedii Herba may be a safe alternative medicine for hypothyroidism.
참고문헌 (37)
- 杜鎬京, "東醫腎系學硏究", pp.401~405 (1991), 東洋醫學硏究院
- 민헌기, "내분비학", pp.270~305 (1999), 고려의학
- 조보연, "임상갑상선학 제2판", pp.409~441 (2005), 고려의학
- 서울대학교 의과대학, "내분비학원론", pp.189~197 (1998), 서울대학교 출판부
- 杜鎬京, "東醫腎系學", pp.1059~1065 (1993), 東洋醫學硏究院
- 大韓東醫生理學會, "東醫生理學", pp.321~ (1993), 慶熙大學校 出版局
- 杜鎬京, "東醫腎系學(上)", pp.10~30 (1991), 東洋醫學硏究院
- Mandel SJ, "Levothyroxine therapy in patients with thyroid disease", Ann Intern Med, 119, pp.492~502 (1993)
- Roti E, "The use and misuse of thyroid hormone", Endocr Rev, 14(4), pp.401~424 (1993)
- Ladenson PW, "Recognition and management of cardiovascular disease related to thyroid dysfunction", Am J Med, 88, pp.638~641 (1990)
- Klein I, "Thyroid hormone and the cardiovascular system", N Engl J Med, 344, pp.501~509 (2001)
- 박용기, "本草學", pp.602~603 (2004), 永林社
- Cai D, "Clinical and experimental research of Epimedium brevicornum in relieving neuroendocrino-immunological effect inhibited by exogenous glucocorticoid", Zhongguo Zhong Xi Yi Jie He Za Zhi, 18, pp.4~7 (1998)
- Ye LC, "Advances in study on pharmacological effects of Epimedium", Zhongguo Zhong Yao Za Zhi, 18, pp.4~7 (1998)
- Tadano T, "Pharmacological studies of nutritive and tonic crude drugs on fatigue in mice", Nippon Yakurigaku Zassi, 100(5), pp.423~431 (1992)
- Xu Min, "Effect of the Yang tonifying herbs on myocardial β-adrenoceptors of hypothyroid rabbits", Journal of Ethnopharmacology, 60, pp.43~51 (1998)
- Kim MS, "A Hyungsang medical study about thyroid disease", 大韓形象醫學會誌, 9(1), pp.351~392 (2008)
- Park JH, "A Study on the relationship between Shin with Thyroid", The Journal of Korean Oriental Internal Medicine, 18(2), pp.305~331 (1997)
- 안세영, "갑상선클리닉", pp.210~248 (2004), 성보사
- Kim SI, "The Effect of Anjeonlejoong-tang on Hypothyroidism : The Prospective Controlled Clinical Study", The Journal of Korean Oriental Internal Medicine, pp.65~72 (2004)
- 杜鎬京, "東醫腎系內科學", pp.573~577 (1989), 東洋醫學硏究院
- Kang KH, "The Clinical Guideline of Anjeonleejoong-tang on Hashimoto' thyroiditis", The Journal of Korean Oriental Internal Medicine, pp.1~8 (2006)
- Kim YS, "Experimental Studies of Kamidaebotang on the Hypothyroidism", The Journal of Korean Oriental Internal Medicine, 15(2), pp.305~317 (1994)
- 민경훈, "八味地黃湯이 Thiouracil로 誘發한 白鼠의 갑상선機能低下에 미치는 影響", 大田大韓醫學硏究所論文集, 5(1), pp.233~250 (1996)
- Lim BS, "The Effects of Woogwi-eum(Yougui-yin) on the Hypothyroidism of Rats", J Korean Oriental Med, 21(4), pp.26~36 (2000)
- 최인구, "眞武湯이 백서의 갑상선기능저하증에 미치는 영향", 대한한방내과학회지, 27(4), pp.879~887 (2006), 대한한방내과학회
- 조충식, "當歸四逆湯이 백서의 갑상선기능저하증에 미치는 영향", 대한본초학회지, 22(1), pp.95~102 (2007), 대한본초학회
- 조충식, "大營煎이 흰쥐의 갑상선기능저하증에 미치는 영향", 대한본초학회지, 22(4), pp.35~43 (2007), 대한본초학회
- 이정원, "當歸四逆加吳茱萸生薑湯이 白鼠의 갑상선기능저하증에 미치는 影響", 석사, 韓醫學科, pp.2001
- 이상헌, "附子가 6-propyl-2-thiouracil(PTU)로 유발된 rat의 갑상선 기능저하증에 미치는 영향", 대한한방내과학회지, 28(2), pp.275~283 (2007), 대한한방내과학회
- 김용석, "人蔘水鍼이 白鼠의 甲狀腺機能低下에 미치는 影響", 경희의학, 6(2), pp.202~210 (1990)
- Yang HT, "Study of effect of cervus nippon temminck aqua-acupuncture on the hypothyroidism induced by thiourea in rats", Journal of Korean Acupuncture and Moxibustion Society, 9(1), pp.215~227 (1992)
- Kang KH, "A case report of Hashimoto's thyroiditis treated with Anjeonleejoong-tang", Korean J.Orient.Int.Med, pp.103~110 (2005)
- Kim YS, "Clinical study of 1 case of patient with Hypothyroidism", Korean Journal of Oriental Medical Prescription, 9(1), pp.397~403 (2001)
- Park SY, "The one case of Hypothyroidism patient. The Journal of Oriental Medical Surgery", Ophthalmology & Otolaryngology, 14(2), pp.286~294 (2001)
- 赵胜利, "淫羊藿对甲状腺机能低下小鼠脑β受体和耗氧率的作用", Journal of Henan Medical University, 31(2), pp.45~47 (1996)
- Choudhury S, "Experimentally induced hypo- and hyper-thyroidism influence on the antioxidant defence system in adult rat testis", andrologia, 35, pp.131~140 (2003)