치주 질환 예방 및 치료용 소재로서 수종의 생약성분 추출물에 관한 항균, 항염, 항산화 효능 연구
Anti-microbial, Anti-inflammatory and Anti-oxidative Effects of Herbal Medicine Extracts as Anti-gingivitis Ingredients
0
조회
0
다운로드
9
인용
0
참고문헌
키워드
초록
This study was to estimate the effect of herbal medicines on periodontal disease. To screen effective materials for periodontal disease, we performed a series of test for 15 herbal medicine extracts. MIC test for P. gingivalis, IL-1αinhibition test, MMP-1 inhibition test and SOD activation test were carried out for herbal medicine extracts, respectively. The results are as followings : 1) Eunhang, Youkdoogu, Daewhang, Hoobak, Goojulcho, Yongacho, Mokhyang, Sesin,Sancho and Hoehyang extracts were effective for reduce P. gingivalis, 2) Eunhang, Jacyak, Youkdoogu, Hagocho,Hoobak, Guaru and Sanyak extracts showed high IL-1α inhibition rates, 3) Eunhang and Youkdoogu extracts have effects on MMP-1 inhibition, 4) Eunhang, Sanyak and Youkdoogu extracts effectively activate SOD. Especially, Eunhang extract has high performance through all estimations and can effectively prevent and treat periodontal disease.
Abstract
This study was to estimate the effect of herbal medicines on periodontal disease. To screen effective materials for periodontal disease, we performed a series of test for 15 herbal medicine extracts. MIC test for P. gingivalis, IL-1αinhibition test, MMP-1 inhibition test and SOD activation test were carried out for herbal medicine extracts, respectively. The results are as followings : 1) Eunhang, Youkdoogu, Daewhang, Hoobak, Goojulcho, Yongacho, Mokhyang, Sesin,Sancho and Hoehyang extracts were effective for reduce P. gingivalis, 2) Eunhang, Jacyak, Youkdoogu, Hagocho,Hoobak, Guaru and Sanyak extracts showed high IL-1α inhibition rates, 3) Eunhang and Youkdoogu extracts have effects on MMP-1 inhibition, 4) Eunhang, Sanyak and Youkdoogu extracts effectively activate SOD. Especially, Eunhang extract has high performance through all estimations and can effectively prevent and treat periodontal disease.
참고문헌 (16)
- The Korean Association for Periodontal Research, "Periodontal research", 116~ (2004)
- Socransky SS, "Microbial complexes in subgingival plaque", J Clin Periodontol, 25, pp.134~144 (1998)
- Offenbacher S, "Periodontal disease at the biofilmgingival interface", J Periodontol, 78(10), pp.1911~1925 (2007)
- Gurenlian, JoAnn R, "The role of dental plaque biofilm in oral health", J Dent Hyg, 81(5), pp.116~ (2007)
- Jeng AY, "Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase", Bioorg Med Chem Lett, 8, pp.897~ (1998)
- Emingil G, "The gingival crevicular fluid and serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 levels in renal transplant patients undergoing different immunosuppressive therapy", J Clin Periodontol, 35(3), pp.221~229 (2008)
- Sorsa T, "The role of gingival crevicular fluid and salivary interstitial collagenases in human periodontal interstitial collagenase in human periodontal diseases", Arch Oral Biol, 35, pp.193~196 (1990)
- Uitto VJ, "Extraction of collagenase from human gingival", J Periodont Res, 12, pp.207~214 (1978)
- Jeon ES, "Antimicrobial activity of Streptococcus mutans by herbal medicine extracts", J Dent Hyg Sci, 2(1), pp.31~38 (2002)
- 윤혜정, "수종의생약헥산분획추출물에의한Streptococcus sobrinus 억제효과", 치위생과학회지, 7(3), pp.197~200 (2007), 한국치위생과학회
- Kim CH, "Antimicrobial effect of Puerariae thunbergiana extracts against oral microorganism", J Dent Hyg Sci, 4(1), pp.45~48 (2004)
- Sreenivasan PK, "Antibacterials as anti-inflammatory agents", Dual action agents for oral health: Antonie Van Leeuwenhoek, 93(3), pp.227~239 (2008)
- Noda D, "Relationship between the presence of periodontopathic bacteria and the expression of chemokine receptor mRNA in inflamed gingival tissues", J Periodontal Res, 42(6), pp.566~571 (2007)
- Katono T, "Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in human osteoblasts", Arch Oral Biol, 54(2), pp.146~155 (2008)
- Pradeep AR, "Gingival crevicular fluid and plasma levels of neuropeptide Substance-P in periodontal health, disease and after nonsurgical therapy", J Periodontal Res, 44(2), pp.232~237 (2008)
- Dong Chen, "Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from porphyromonas gingivalis", Pharmacology, 82(4), pp.264~269 (2008)