흡연이 치은열구액 내 Matrix Metalloproteinase-9에 미치는 영향
Influence of Smoking on Matrix Metalloproteinase-9 in the Gingival Crevicular Fluid
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초록
Matrix metalloproteinase(MMP)-9 is considered important in tissue destruction in periodontitis. The aim of this study was to investigate the influence of smoking on MMP-9 in the gingival crevicular fluid(GCF). GCF samples in upper incisors area from 332 male subjects were collected after the informed consent. The dental examination included the assessment of oral hygiene, gingival inflammation and probing pocket depth. A quantitative assessment of MMP-9levels in GCF was performed utilizing and immunological procedure. The mean MMP-9 concentrations found in GCF of smokers(30.86 ng/ml) and quit-smokers(29.82 ng/ml) differed from non-smokers(11.33 ng/ml), adjusted by age, gingival index and Community periodontal index(p<0.001). Smoking seems to influence MMP-9 in GCF regardless of gingival inflammation and age. It means smoking can destruct the periodontal tissue for itself.
Abstract
Matrix metalloproteinase(MMP)-9 is considered important in tissue destruction in periodontitis. The aim of this study was to investigate the influence of smoking on MMP-9 in the gingival crevicular fluid(GCF). GCF samples in upper incisors area from 332 male subjects were collected after the informed consent. The dental examination included the assessment of oral hygiene, gingival inflammation and probing pocket depth. A quantitative assessment of MMP-9levels in GCF was performed utilizing and immunological procedure. The mean MMP-9 concentrations found in GCF of smokers(30.86 ng/ml) and quit-smokers(29.82 ng/ml) differed from non-smokers(11.33 ng/ml), adjusted by age, gingival index and Community periodontal index(p<0.001). Smoking seems to influence MMP-9 in GCF regardless of gingival inflammation and age. It means smoking can destruct the periodontal tissue for itself.
참고문헌 (25)
- 2010년도 흡연예방 및 금연클리닉 사업 안내, "보건복지부", 보건복지부, ~ (2010)
- Yanagisawa T, "Relationship of smoking and smoking cessation with number of teeth present:JPHC oral health study", Oral Dis, 15(1), pp.69~75 (2009)
- 김혜영, "대전 동구 일부 노인의 흡연, 경제적 상태와 노인 구강건강의 연관성", 대한구강보건학회지, 35(1), pp.67~76 (2011), 대한구강보건학회
- Tanaka J, "Household smoking and dental caries in schoolchildren:the Ryukyus Child Health Study", BMC Public Health, 10, pp.335~ (2010)
- Campus G, "Dose smoking increase risk for caries? A cross-sectional study in an italian military academy", Caries Res, 45(1), pp.40~46 (2011)
- Sakki T, "Controlled study of the association of smoking with lactobacilli,mutans streptococci and yeasts in saliva", Eur J Oral Sci, 104(5), pp.619~622 (1996)
- Yazdini R, "Smoking,tooth brushing and oral cleanliness among 15-year-olds in Tehran,Iran", Oral Health Prev Dent, 6(1), pp.45~51 (2008)
- Fullmer SC, "Smoking Cessation Alters Subgingival Microbial Recolonization", J Dent Res, 88(6), pp.524~528 (2009)
- Grossi SG, "Effects of smoking and smoking cessation on healing after mechanical periodontal therapy", J Am Dent Assoc, 128(5), pp.599~607 (1997)
- 김탁, "니코틴이 치은섬유아세포의 세포주기 조절 단백질 발 현에 미치는 영향", 대한치주과학회지, 31(3), pp.597~610 (2001)
- Zhang W, "Effects of cigarette smoke condensate and nicotine on human gingival fibroblast-mediated collagen degradation", J Periodontol Dec, 13 (2010)
- Becerik S, "Effects of menstrual cycle on periodontal health and gingival crevicular fluid markers", J Periodontol, 81(5), pp.673~681 (2010)
- Uitto VJ, "Proteolytic host cell enzymes in gingival crevice fluid", Periodontology 2000, 31(1), pp.77~104 (2003)
- Visse R, "Matrix metalloproteinases and tissue inhibitors of metalloproteinases:structrure,function and biochemistry", Circ Res, 92(8), pp.827~839 (2003)
- Hannas AR, "The role of matrix metalloproteinases in the oral environment", Acta Odontolgica Scandinavica, 65(1), pp.1~13 (2007)
- Marcaccini AM, "Gingival crevicular fluid levels of MMP-8,MMP-9,TIMP-2,and MPO decrease after periodontal therapy", J Clin Periodontol, 37(2), pp.180~190 (2010)
- Sorsa T, "Cellular source,activation and inhibition of dental plaque collagenase", J Clin Periodontol, 22(9), pp.709~717 (1995)
- Lee W, "Evidence of a direct relationship between neutrophil collagenase activity and periodontal tissure destruction in vivo:role of active enzyme in human periodontitis", J periodontal Res, 30(1), pp.23~33 (1995)
- Mantyla P, "Gingival crevicular fluid collagenase-2(MMP-8)test strip for chair-side monitoring of periodontits", J Periodontol Res, 38(4), pp.436~439 (2003)
- 황수정, "실험치은염모형에서 흡연의 영향", 대한구강보건학회지, 32(4), pp.434~442 (2008), 대한구강보건학회
- Inui T, "Matrix metalloproteinases and lysosomal cystein proteases in osteoclasts contribute to bone resorptio through distinct modes of action", Biochem Biophys Res Commun, 258(1), pp.173~178 (1999)
- 김한홍, "일부지역 실업계 고등학교 남학생의 구강관리실태 및 흡연과 치은염과의 상관성 분석", 치위생과학회지, 9(5), pp.513~518 (2009), 한국치위생과학회
- 장분자, "일부 대학 스켈링센터 방문환자의 흡연 및 음주와 치주낭 형성의 관련성", 치위생과학회지, 10(2), pp.117~122 (2010), 한국치위생과학회
- 김희경, "일부 치위생(학)과 학생들의 흡연실태 및 인식도 조사", 치위생과학회지, 9(2), pp.241~247 (2009), 한국치위생과학회
- 김숙향, "일부 대학생의 흡연 행위와 주관적 구강건강 인식 도와의 관련성", 치위생과학회지, 5(3), pp.139~143 (2005)