Relationship Between Chronic Periodontitis and Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia
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Purpose: We investigated the relationship between lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and chronic periodontitis (CP). Methods: A total of 103 middle-aged men who had received a health checkup were included. All participant data were prospectively collected. CP was defined as a 30% increase in the number of probed sites with a clinical attachment level of ≥4 mm among all probed sites. LUTS/BPH were assessed using transrectal ultrasonography, the International Prostate Symptom Score (IPSS), uroflowmetry, and postvoiding residual urine volume. Results: The median age, IPSS, prostate volume, and maximal flow rate were 55.0 years, 9.0, 29.0 mL, and 20.0 mL/sec, respectively. In addition, the prevalence of CP was 27.2%. The IPSS total, IPSS voiding, IPSS storage, and quality of life (QoL) scores were significantly higher in patients with CP (median [interquartile range, IQR]–IPSS total: 8.0 [5.0–13.5] vs. 12.0 [7.5–20.5], P=0.004; IPSS voiding: 5.0 [2.0–9.0] vs. 8.5 [4.0–15.0], P=0.002; IPSS storage: 3.0 [2.0–5.0] vs. 4.0 [3.0–6.0], P=0.021; QoL: 2.0 [1.0–3.0] vs. 3.0 [2.0–4.0], P=0.015). Additionally, the average flow rate was significantly lower in patients with CP (median [IQR] (mL/sec): 9.0 [8.0–13.0] vs. 8.0 [6.0–11.0], P=0.047). After adjustment for age, testosterone level, prostate volume, glucose level, cholesterol level, and waist circumference, the IPSS total and voiding scores were significantly and positively related to CP (IPSS total: odds ratio [OR], 1.141; 95% confidence interval [CI], 1.045–1.245; P=0.003; IPSS voiding: OR, 1.243; 95% CI, 1.092–1.415; P=0.001). Conclusions: Our data suggest that LUTS/BPH is significantly related to CP.
Abstract
Purpose: We investigated the relationship between lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and chronic periodontitis (CP). Methods: A total of 103 middle-aged men who had received a health checkup were included. All participant data were prospectively collected. CP was defined as a 30% increase in the number of probed sites with a clinical attachment level of ≥4 mm among all probed sites. LUTS/BPH were assessed using transrectal ultrasonography, the International Prostate Symptom Score (IPSS), uroflowmetry, and postvoiding residual urine volume. Results: The median age, IPSS, prostate volume, and maximal flow rate were 55.0 years, 9.0, 29.0 mL, and 20.0 mL/sec, respectively. In addition, the prevalence of CP was 27.2%. The IPSS total, IPSS voiding, IPSS storage, and quality of life (QoL) scores were significantly higher in patients with CP (median [interquartile range, IQR]–IPSS total: 8.0 [5.0–13.5] vs. 12.0 [7.5–20.5], P=0.004; IPSS voiding: 5.0 [2.0–9.0] vs. 8.5 [4.0–15.0], P=0.002; IPSS storage: 3.0 [2.0–5.0] vs. 4.0 [3.0–6.0], P=0.021; QoL: 2.0 [1.0–3.0] vs. 3.0 [2.0–4.0], P=0.015). Additionally, the average flow rate was significantly lower in patients with CP (median [IQR] (mL/sec): 9.0 [8.0–13.0] vs. 8.0 [6.0–11.0], P=0.047). After adjustment for age, testosterone level, prostate volume, glucose level, cholesterol level, and waist circumference, the IPSS total and voiding scores were significantly and positively related to CP (IPSS total: odds ratio [OR], 1.141; 95% confidence interval [CI], 1.045–1.245; P=0.003; IPSS voiding: OR, 1.243; 95% CI, 1.092–1.415; P=0.001). Conclusions: Our data suggest that LUTS/BPH is significantly related to CP.
참고문헌 (31)
- "1999 International International Workshop for a Classification of Periodontal Diseases and Conditions. Papers. Oak Brook, Illinois, October 30-November 2, 1999", Ann Periodontol, 4, pp.1~112 (1999)
- Lee JH, "Association of lifestyle-related comorbidities with periodontitis: a nationwide cohort study in Korea", Medicine (Baltimore), 94, pp.e1567~ (2015)
- Dietrich T, "Associations between periodontal disease and systemic disease : evaluating the strength of the evidence", J Periodontol (2005)
- D’Aiuto F, "Association of the metabolic syndrome with severe periodontitis in a large U.S. population-based survey", J Clin Endocrinol Metab, 93, pp.3989~3994 (2008)
- Li P, "Relationship of metabolic syndrome to chronic periodontitis", J Periodontol, 80, pp.541~549 (2009)
- Higashi Y, "Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients", Hypertension, 51, pp.446~453 (2008)
- Jun Ho Lee, "The Relationships between Thyroid Hormone Levels and Lower Urinary Tract Symptoms", Benign Prostatic Hyperplasia, 2019, pp.37(3), 364~371[DOI]
- 고일규, "Add-on Therapy With the α-Blockers Tamsulosin and Naftopidil Improves Voiding Function by Enhancing Neuronal Activity in Prostatic Hyperplasia Rats", International Neurourology Journal, 22(1), pp.20~29 (2018), 대한배뇨장애요실금학회
- Lee HL, "The prevalence of benign prostatic hyperplasia : community-based study in Chungbuk province", Korean J Urol, 40, pp.1500~1505 (1999)
- Eke PI, "CDC Periodontal Disease Surveillance Project:background, objectives, and progress report", J Periodontol, 78(7 Suppl), pp.1366~1371 (2007)
- Gratzke C, "EAU Guidelines on the assessment of nonneurogenic male lower urinary tract symptoms including benign prostatic obstruction", Eur Urol, 67, pp.1099~1109 (2015)
- Rhodes T, "Longitudinal prostate growth rates during 5 years in randomly selected community men 40 to 79 years old", J Urol, 161, pp.1174~1179 (1999)
- 허정식, "Prevalence of Benign Prostatic Hyperplasia on Jeju Island: Analysis from a Cross-sectional Community-based Survey", The World Journal of Men's Health, 30(2), pp.131~137 (2012), 대한남성과학회[DOI]
- Yeon Won Park, "Relationship between Lower Urinary Tract Symptoms", Benign Prostatic Hyperplasia and Metabolic Syndrome in Korean Men, 2012, pp.30(3), 183~188[DOI]
- Genco RJ, "Risk factors for periodontal disease", Periodontol 2000, 62, pp.59~94 (2013)
- Lianhui Y, "Association between chronic periodontitis and hyperlipidemia : a Meta-analysis based on observational studies", Hua Xi Kou Qiang Yi Xue Za Zhi, 35, pp.419~426 (2017)
- Kellesarian SV, "Low testosterone levels in body fluids are associated with chronic periodontitis", Am J Mens Health, 11, pp.443~453 (2017)
- Calogero AE, "Epidemiology and risk factors of lower urinary tract symptoms", benign prostatic hyperplasia and erectile dysfunction, 2019, pp.22, 12~19
- Korean Diabetes Association, "Diabetes fact sheet in Korea 2016", pp.2~8 (2016), Korean Diabetes Association
- Sarma AV, "Clinical practice. Benign prostatic hyperplasia and lower urinary tract symptoms", N Engl J Med, 367, pp.248~257 (2012)
- Matsumoto S, "Association between chronic periodontal disease and lower urinary tract symptoms in both sexes", Low Urin Tract Symptoms, 7, pp.17~21 (2015)
- Boland MR, "Discovering medical conditions associated with periodontitis using linked electronic health records", J Clin Periodontol, 40, pp.474~482 (2013)
- Birman-Deych E, "Accuracy of ICD-9-CM codes for identifying cardiovascular and stroke risk factors", Med Care, 43, pp.480~485 (2005)
- Eckel RH, "The metabolic syndrome", Lancet, 375, pp.181~183 (2010)
- Gurav AN, "The association of periodontitis and metabolic syndrome", Dent Res J(Isfahan), 11, pp.1~10 (2014)
- Kupelian V, "Association of lower urinary tract symptoms and the metabolic syndrome : results from the Boston area community health survey", J Urol (2013)
- Park YW, "The relationship between lower urinary tract symptoms", benign prostatic hyperplasia and the number of components of metabolic syndrome, 2013, pp.82, 674~679
- Estemalik J, "Simultaneous detection of oral pathogens in subgingival plaque and prostatic fluid of men with periodontal and prostatic diseases", J Periodontol, 88, pp.823~829 (2017)
- Khan FU, "Comprehensive overview of prostatitis", Biomed Pharmacother, 94, pp.1064~1076 (2017)
- Fibbi B, "Chronic inflammation in the pathogenesis of benign prostatic hyperplasia", Int J Androl, 33, pp.475~488 (2010)
- Lloyd GL, "Benign prostatic hyperplasia and lower urinary tract symptoms : what is the role and significance of inflammation", Curr Urol Rep, 20, pp.54~ (2019)