Single Intramuscular-dose Toxicity of Samgihwalryeok-Pharmacopuncture in Sprague-Dawley Rats
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objectives: This study was performed to examine the single-dose toxicity of Samgihwalryeok pharmacopuncture. Methods: Forty six-week-old Sprague-Dawley (SD) rats were divided into four groups of 10 rats each; each group was then sub-divided into two smaller groups, one of five males and the other of five females. Group 1 (G1, control) received 1.0 mL of normal saline solution, while group 2 (G2, low-dose group), group 3 (G3, mid-does group, and group 4 (G4, high-dose group) received 0.1, 0.5, and 1.0 mL of Samgihwalryeok pharmacopuncture, respectively. Results: No mortalities or clinical signs were observed in the four groups. Also, no significant changes in body weights were observed among the group, and no significant differences in hematology/biochemistry, necropsy, or histopathology results were noted. Conclusion: The above findings suggest that treatment with Samgihwalryeok pharmacopuncture is relatively safe. Further studies on this subject are needed.
Abstract
Objectives: This study was performed to examine the single-dose toxicity of Samgihwalryeok pharmacopuncture. Methods: Forty six-week-old Sprague-Dawley (SD) rats were divided into four groups of 10 rats each; each group was then sub-divided into two smaller groups, one of five males and the other of five females. Group 1 (G1, control) received 1.0 mL of normal saline solution, while group 2 (G2, low-dose group), group 3 (G3, mid-does group, and group 4 (G4, high-dose group) received 0.1, 0.5, and 1.0 mL of Samgihwalryeok pharmacopuncture, respectively. Results: No mortalities or clinical signs were observed in the four groups. Also, no significant changes in body weights were observed among the group, and no significant differences in hematology/biochemistry, necropsy, or histopathology results were noted. Conclusion: The above findings suggest that treatment with Samgihwalryeok pharmacopuncture is relatively safe. Further studies on this subject are needed.
참고문헌 (19)
- Korean pharmacopuncture, "Pharmacopuncture therapy guidelines", pp.146~ (1999), Hansung printing
- Yook TH., "Clinical observation about the extent of improvement of low back pain patient through medi-acupuncture therapy", J Korean Oriental Med, 16(1), pp.184~197 (1995)
- Joo HJ., "Researches on Parmacopuncture", pp.5~ (1995), Korea Institute of Oriental medicine
- 이유환, "삼기활력약침이 불면, 피로에 미치는 효과", 대한침구의학회지, 29(3), pp.101~113 (2012), 대한침구의학회[DOI]
- "Good laboratory practice regulation for non-clinical laboratory studies (KFDA Notification No. 2012-86)" (2012)[URL]
- Korean Pharmacopuncture, "Institute Pharmacopuncturology", pp.3~21 (2008), Elsevier Korea LLC
- 임사비나, "The Effects of Cervus elaphus Aquapuncture and Ginseng Radix Aquapuncture on the Growth of Animals", Journal of Pharmacopuncture, 3(2), pp.131~152 (2000), 대한약침학회[DOI]
- 설현, "인삼약침과 산조인약침이 정상인의 심박 변이도에 미치는 영향", 대한침구의학회지, 26(5), pp.19~28 (2009), 대한침구의학회
- 이혜정, "The Effect of Herb-acupunctures of Bojoongiggi-tang (Buzhongyiqi-tang), Ginseng Radix, and Astragali Radix on Immune Responses in Rats", Journal of Pharmacopuncture, 3(2), pp.79~97 (2000), 대한약침학회[DOI]
- 이익재, "인삼약침이 소음스트레스로 인한 태아쥐의 NOS 신경세포 발현에 미치는 영향", Korean Journal of Acupuncture, 23(4), pp.157~167 (2006), 경락경혈학회
- 위종성, "A549 폐암세포와 Sarcoma-180 복강암에 대한 人蔘 蒸溜藥鍼의 영향에 關한 實驗的 硏究", Journal of Pharmacopuncture, 7(3), pp.59~71 (2004), 대한약침학회
- 한상원, "A Study on Effects of the Cervi Pantotricuhum Cornu Herb-acupuncture on the Osteoporosis Induced by Ovariectomy in Rats", Journal of Pharmacopuncture, 3(1), pp.177~191 (2000), 대한약침학회[DOI]
- 송봉근, "당귀 추출물 정맥 주사가 Middle Cerebral Artery Occlusion 모델 흰쥐에서 Gliosis 억제에 미치는 영향", Journal of Pharmacopuncture, 14(3), pp.5~18 (2011), 대한약침학회
- 김경식, "The Effect of Radix Angelicae gigantis aqua-acupuncture on the hypothyroidism induced by thiourea in rats", Journal of Pharmacopuncture, 1(1), pp.53~76 (1997), 대한약침학회[DOI]
- 이응석, "맥문동이 LPS로 유도된 폐손상에 미치는 영향", 동의생리병리학회지, 25(4), pp.641~649 (2011), 대한동의병리학회
- 박수환, "麥門冬이 4-HNE에 의해 유도된 Apoptosis에 미치는 영향", 대한본초학회지, 28(2), pp.33~38 (2013), 대한본초학회
- 장선일, "Dextran Sulfate Sodium 유도 마우스 대장염에 미치는 오미자와 매실의 상승효과", 대한한의학 방제학회지, 17(2), pp.85~98 (2009), 대한한의학방제학회
- Kim YG., "Toxicology", pp.15~18 (1984), Donghwagisul
- Korea Food & Drug Administration., "Korea Food & Drug Administration notification", 60~ (2005)