The Relationship Between Nocturia and Mortality: Data From the National Health and Nutrition Examination Survey
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Purpose: We investigated the relationship between nocturia and mortality risk in the United States. Methods: Data were obtained from the National Health and Nutrition Examination Survey 2005–2010. Mortality data were obtained by linking the primary database to death certificate data found in the National Death Index with mortality follow-up up to December 31, 2015. Nocturia was defined based on symptoms reported in the symptom questionnaire. We categorized patients into 2 groups: mild nocturia (2–3 voids/night) and moderate-to severe nocturia (≥4 voids/night). Multiple Cox regression analyses were performed with adjustment for confounding variables at the baseline survey. Results: This study included 9,892 adults (4,758 men, 5,134 women). Nocturia occurred in 3,314 individuals (33.5%). Nocturia was significantly associated with all-cause mortality (hazard ratio [HR], 1.23; 95% confidence interval [CI], 1.10–1.39) and cardiovascular disease (CVD) mortality (HR, 1.55; 95% CI, 1.19–2.01). Moreover, the mortality risk increased with increasing nocturia severity. Further analysis with propensity score matching showed that nocturia was still significantly associated with all-cause mortality and CVD mortality. In subgroup analysis according to sex, nocturia was significantly associated with allcause mortality and CVD mortality in men. In women, moderate-to-severe nocturia was significantly associated with allcause mortality and CVD mortality. In subgroup analysis according to cardio-metabolic diseases, nocturia was associated with CVD mortality in patients with diabetes mellitus, hypertension, dyslipidemia, or CVD at baseline. In subgroup analysis of patients without diabetes mellitus, hypertension or CVD, nocturia was significantly associated with all-cause mortality. Conclusions: Nocturia was significantly associated with mortality in men and women after adjusting for major confounding factors.
Abstract
Purpose: We investigated the relationship between nocturia and mortality risk in the United States. Methods: Data were obtained from the National Health and Nutrition Examination Survey 2005–2010. Mortality data were obtained by linking the primary database to death certificate data found in the National Death Index with mortality follow-up up to December 31, 2015. Nocturia was defined based on symptoms reported in the symptom questionnaire. We categorized patients into 2 groups: mild nocturia (2–3 voids/night) and moderate-to severe nocturia (≥4 voids/night). Multiple Cox regression analyses were performed with adjustment for confounding variables at the baseline survey. Results: This study included 9,892 adults (4,758 men, 5,134 women). Nocturia occurred in 3,314 individuals (33.5%). Nocturia was significantly associated with all-cause mortality (hazard ratio [HR], 1.23; 95% confidence interval [CI], 1.10–1.39) and cardiovascular disease (CVD) mortality (HR, 1.55; 95% CI, 1.19–2.01). Moreover, the mortality risk increased with increasing nocturia severity. Further analysis with propensity score matching showed that nocturia was still significantly associated with all-cause mortality and CVD mortality. In subgroup analysis according to sex, nocturia was significantly associated with allcause mortality and CVD mortality in men. In women, moderate-to-severe nocturia was significantly associated with allcause mortality and CVD mortality. In subgroup analysis according to cardio-metabolic diseases, nocturia was associated with CVD mortality in patients with diabetes mellitus, hypertension, dyslipidemia, or CVD at baseline. In subgroup analysis of patients without diabetes mellitus, hypertension or CVD, nocturia was significantly associated with all-cause mortality. Conclusions: Nocturia was significantly associated with mortality in men and women after adjusting for major confounding factors.
참고문헌 (26)
- van Kerrebroeck P, "The standardisation of terminology in nocturia : report from the Standardisation Sub-committee of the International Continence Society", Neurourol Urodyn, 21, pp.179~183 (2002)
- Hashim H, "International Continence Society(ICS)report on the terminology for nocturia and nocturnal lower urinary tract function", Neurourol Urodyn, 38, pp.499~508 (2019)
- Funada S, "Impact of nocturia on mortality : the nagahama study", J Urol, 204, pp.996~1002 (2020)
- Kupelian V, "Association of nocturia and mortality : results from the Third National Health and Nutrition Examination Survey", J Urol, 185, pp.571~577 (2011)
- 문신제, "The Association Between Obesity and the Nocturia in the U.S. Population", International Neurourology Journal, 23(2), pp.169~176 (2019), 대한배뇨장애요실금학회[DOI]
- Bosch JL, "The prevalence and causes of nocturia", J Urol, 189, pp.S86~S92 (2013)
- Lombardo R, "Nocturia: the complex role of the heart, kidneys, and bladder", Eur Urol Focus, 6, pp.534~536 (2020)
- Bliwise DL, "Nocturia and associated mortality : observational data from the REDUCE trial", Prostate Cancer Prostatic Dis, 22, pp.77~83 (2019)
- Pesonen JS, "The impact of nocturia on mortality : a systematic review and meta-analysis", J Urol, 203, pp.486~495 (2020)
- Soysal P, "Trends and prevalence of nocturia among US adults, 2005-2016", Int Urol Nephrol, 52, pp.805~813 (2020)
- Centers for Disease Control and Prevention, "The linkage of national center for health statistics survey data to the national death index—2015 linked mortality file (LMF): methodology overview and analytic considerations" (2019), Centers for Disease Control and Prevention
- Moon S, "Association of nocturia and cardiovascular disease : data from the National Health and Nutrition Examination Survey", Neurourol Urodyn, 40, pp.1569~1575 (2021)
- Akerla J, "Impact of lower urinary tract symptoms on mortality : a 21-year follow-up among middle-aged and elderly Finnish men", Prostate Cancer Prostatic Dis, 22, pp.317~323 (2019)
- Vincent GK, "The next four decades: The older population in the United States: 2010 to 2050" (2010), United States Census Bureau
- Tikkinen KA, "Nocturia frequency, bother, and quality of life:how often is too often? A population-based study in Finland", Eur Urol, 57, pp.488~496 (2010)
- Hakkinen JT, "Incidence of nocturia in 50 to 80-year-old Finnish men", J Urol, 176, pp.2541~2545 (2006)
- Bursztyn M, "Usefulness of nocturia as a mortality risk factor for coronary heart disease among persons born in 1920 or 1921", Am J Cardiol, 98, pp.1311~1315 (2006)
- Knutson KL, "Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus", Arch Intern Med, 166, pp.1768~1774 (2006)
- Obayashi K, "Independent associations between nocturia and nighttime blood pressure", dipping in elderly individuals : the HEIJO-KYO cohort, 2015, pp.63, 733~738
- Pesonen JS, "The impact of nocturia on falls and fractures : a systematic review and meta-analysis", J Urol, 203, pp.674~683 (2020)
- Tikkinen KA, "A systematic evaluation of factors associated with nocturia--the population-based FINNO study", Am J Epidemiol, 170, pp.361~368 (2009)
- Fitzgerald MP, "The association of nocturia with cardiac disease, diabetes, body mass index, age and diuretic use: results from the BACH survey", J Urol, 177, pp.1385~1389 (2007)
- Lightner DJ, "Nocturia is associated with an increased risk of coronary heart disease and death", BJU Int, 110, pp.848~853 (2012)
- Vaughan CP, "The fluctuation of nocturia in men with lower urinary tract symptoms allocated to placebo during a 12-month randomized, controlled trial", J Urol, 191, pp.1040~1044 (2014)
- Temml C, "Nocturia is an age-independent risk factor for hip-fractures in men", Neurourol Urodyn, 28, pp.949~952 (2009)
- Moon S, "The impact of urinary incontinence on falls : A systematic review and meta-analysis", PLoS One, 16, pp.e0251711~ (2021)