Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone

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참고문헌 (111)

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15. Hosseinzadeh H, "Antitussive effect of thymoquinone, a constituent of Nigella sativa seeds, in guinea pigs", Pharmacologyonline, 2, pp.480~484 (2008)
16. Salem ML, "Immunomodulatory and therapeutic properties of the Nigella sativa L. seed", Int Immunopharmacol, 5(13-14), pp.1749~1770 (2005)
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18. Hosseinzadeh H, "Effect of Nigella sativa seed extracts on ischemiareperfusion in rat skeletal muscle", Pharmacologyonline, 2, pp.326~335 (2007)
19. Hosseinzadeh H, "Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus", Phytomedicine, 14(9), pp.621~627 (2007)
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21. Razavi B, "A review of the effects of Nigella sativa L. and its constituent, thymoquinone, in metabolic syndrome", J Endocrinol Invest, 37(11), pp.1031~1040 (2014)
22. Parvardeh S, "Study on the anticonvulsant activity of thymoquinone, the major constituent of Nigella sativa L. seeds, through intracerebroventricular injection", J Med Plants, 4, pp.45~52 (2005)
23. Hosseinzadeh H, "Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats", Med Sci Monit, 11(4), pp.106~110 (2005)
24. Hosseinzadeh H, "Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice", Phytomedicine, 11(1), pp.56~64 (2004)
25. Pourbakhsh H, "Effect of Nigella sativa fixed oil on ethanol toxicity in rats", Iran J Basic Med Sci, 17(12), pp.1020~1031 (2014)
26. Mehri S, "Neuroprotective effect of thymoquinone in acrylamideinduced neurotoxicity in wistar rats", Iran J Basic Med Sci, 17(12), pp.1007~1011 (2014)
27. Javidi S, "A review of neuropharmacology effects of Nigella sativa and its main component, thymoquinone", Phytother Res, 30(8), pp.1219~1229 (2016)
28. Havakhah S, "Effect of Nigella sativa on ischemia-reperfusion induced rat kidney damage", Iran J Basic Med Sci, 17(12), pp.986~992 (2014)
29. Hosseinzadeh H, "Protective effect of Nigella sativa L. extracts and thymoquinone, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats", Pharmacologyonline, 1, pp.176~189 (2007)
30. Amini M, "Hypolipidemic effects of Nigella sativa L. seeds oil in healthy volunteers: a randomized, doubleblind, placebo-controlled clinical trial", J Med Plants, 10, pp.133~138 (2011)
31. Huseini HF, "Blood pressure lowering effect of Nigella sativa L. seed oil in healthy vol-unteers: a randomized, double-blind, placebo-controlled clinical trial", Phytother Res, 27(12), pp.1849~1853 (2013)
32. Bilal A, "Effects of Nigella sativa oil on some blood parameters in type 2 diabetes mellitus patients", Asian J Chem, 21(7), pp.5373~5381 (2009)
33. Datau EA, "Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male", Acta Med Indones, 42(3), pp.130~134 (2010)
34. Qidwai W, "Effectiveness, safety, and tolerability of powdered Nigella sativa(kalonji)seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults : results of a randomized, double-blind controlled trial", J Altern Complement Med, 15(6), pp.639~644 (2009)
35. Bamosa AO, "Effect of Nigella Sativa seeds on the glycemic control of patients with type 2 diabetes mellitus", Indian J Physiol Pharmacol, 54(4), pp.344~354 (2010)
36. Bilal A, "BS5-5 Black seed(Nigella sativa)regulates glucose, insulin level and lipid profile in patients with type 2 diabetes", Diabetes Res Clin Pract, 79, pp.19~20 (2008)
37. El-Shamy KA, "Effect of Nigella sativa tea in type 2-diabetic patients as regards glucose homeostasis, liver and kidney functions", J Appl Sci Res, 7(12), pp.2524~2534 (2011)
38. Dehkordi FR, "Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension", Fundam Clin Pharmacol, 22(4), pp.447~452 (2008)
39. Ghorbanibirgani A, "Comparing Nigella sativa oil and fish oil in treatment of vitiligo", Iran Red Crescent Med J, 16(6), pp.e4515~ (2014)
40. Valizadeh N, "The effect of Nigella sativa extract on biochemical bone markers in osteopenic postmenopausal women", Iran J Endocrinol Metab, 10(6), pp.571~580 (2009)
41. Kolahdooz M, "Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial", Phytomedicine, 21(6), pp.901~905 (2014)
42. Mohtashami R, "Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia : a double blind randomized controlled clinical trial", J Ethnopharmacol, 175, pp.147~152 (2015)
43. Barakat EMF, "Effects of Nigella sativa on outcome of hepatitis C in Egypt", World J Gastroenterol, 19(16), pp.2529~2536 (2013)
44. Dirjomuljono M, "Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract", Int J Clin Pharmacol Ther, 46(6), pp.295~306 (2008)
45. Akhtar MS, "Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children", J Pak Med Assoc, 41(8), pp.185~187 (1991)
46. Ansari MA, "Montelukast ver-sus Nigella sativa for management of seasonal allergic rhinitis : a single blind comparative clinical trial", Pak J Med Sci, 26(2), pp.249~254 (2010)
47. Alsamarai AM, "Evaluation of topical black seed oil in the treatment of allergic rhinitis", Antiinflamm Antiallergy Agents Med Chem, 13(1), pp.75~82 (2014)
48. Dogar MZUH, "Preliminary assessment of efficacy of Nigella sativa seeds in acute lymphoblastic leukemia in local children", Pharmacologyonline, 2, pp.769~777 (2009)
49. Arslan E, "A case study report of acute renal failure associated with Nigella sativa in a diabetic patient", J Integr Med, 11(1), pp.64~66 (2013)
50. Bamosa A, "Nigella sativa is a safe herbal product", J Integr Med, 12(1), pp.66~ (2014)
51. Ibraheim ZZ, "Effect of Nigella sativa seeds and total oil on some blood parameters in female volunteers", Saudi Pharm J, 10, pp.54~59 (2002)
52. Gelot P, "Bullous drug eruption with Nigella sativa oil", Ann Dermatol Venereol, 139(4), pp.287~291 (2012)
53. French. Al-Jenoobi FI, "Effect of black seed on dextromethorphan O-and N-demethylation in human liver microsomes and healthy human subjects", Drug Metab Lett, 4(1), pp.51~55 (2010)
54. Lonardo A, "Nonalcoholic fatty liver disease : a precursor of the metabolic syndrome", Dig Liver Dis, 47(3), pp.181~190 (2015)
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56. Najmi A, "Effect of Nigella sativa oil on various clinical and biochemical parameters of metabolic syndrome", Int J Diabetes Metab, 16, pp.85~87 (2008)
57. Amin F, "Clinical efficacy of the co-administration of Turmeric and Black seeds(Kalongi)in metabolic syndrome-a double blind randomized controlled trial-TAK-MetS trial", Complement Ther Med, 23(2), pp.165~174 (2015)
58. Latiff LA, "Alternative supplement for enhancement of reproductive health and metabolic profile among perimenopausal women : a novel role of Nigella sativa", Iran J Basic Med Sci, 17(12), pp.980~985 (2014)
59. Najmi A, "Therapeutic effect of Nigella sativa in patients of poor glycemic control", Asian J Pharm Clin Res, 5, pp.224~228 (2012)
60. Lee MJ, "Adipose tissue heterogeneity : implication of depot differences in adipose tissue for obesity complications", Mol Aspects Med, 34(1), pp.1~11 (2013)
61. Namazi N, "Oxidative stress responses to Nigella sativa oil concurrent with a low-calorie diet in obese women : a randomized, double-blind controlled clinical trial", Phytother Res, 29(11), pp.1722~1728 (2015)
62. Mahdavi R, "Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women : a randomized controlled clinical trial", Food Funct, 6(6), pp.2041~2048 (2015)
63. Ni WQ, "Serum lipids and associated factors of dyslipidemia in the adult population in Shenzhen", Lipids Health Dis, 14, pp.71~ (2015)
64. Moeen-ud-din H, "Placebo controlled study on comparison of effects of Nigella sativa and nicotinic acid along with low fat diet and physical exercise on LDL-cholesterol and HDL-cholesterol", Pak J Med Health Sci, 8, pp.306~309 (2014)
65. Fatima A, "Effects of Nigella sativa on HDL-c & body weight", Pak J Med Health Sci, 8(1), pp.122~124 (2014)
66. Ibrahim RM, "A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women", J Transl Med, 12, pp.82~ (2014)
67. Ibrahim RM, "Protective effects of Nigella sativa on metabolic syndrome in menopausal women", Adv Pharm Bull, 4(1), pp.29~33 (2014)
68. Mathews MJ, "The mechanism by which moderate alcohol consumption influences coronary heart disease", Nutr J, 14, pp.33~ (2015)
69. Tasawar Z, "The effects of Nigella sativa(Kalonji)on lipid profile in patients with stable coronary artery disease in Multan, Pakistan", Pak J Nut, 10, pp.162~167 (2011)
70. Bamosa AO, "Effect of oral ingestion of Nigella sativa seeds on some blood parameters", Saudi Pharm J, 2, pp.126~129 (2007)
71. Ahmad Alobaidi AH, "Effect of Nigella sativa and Allium sativum coadminstered with simvastatin in dyslipidemia patients : a prospective, randomized, doubleblind trial", Antiinflamm Antiallergy Agents Med Chem, 13(1), pp.68~74 (2014)
72. Sabzghabaee AM, "Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia : a randomized, placebo controlled clinical trial", Med Arch, 66(3), pp.198~200 (2012)
73. Roufogalis B, "No statistically significant effects of powdered Nigella sativa(kalonji)seed on serum lipid levels, blood sugar, blood pressure or body weight in adults", Focus Altern Complement Ther, 14(4), pp.292~294 (2009)
74. Asgary S, "Ameliorative effects of Nigella sativa on dyslipidemia", J Endocrinol Invest, 38(10), pp.1039~1046 (2015)
75. Sahebkar A, "Nigella sativa(black seed)effects on plasma lipid concentrations in humans : a systematic review and meta-analysis of randomized placebo-controlled trials", Pharmacol Res, 106, pp.37~50 (2016)
76. Kaatabi H, "Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: placebo controlled participant blinded clinical trial", PLoS One, 10(2), pp.e0113486~ (2015)
77. Heshmati J, "Nigella sativa oil affects glucose metabolism and lipid concentrations in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial", Food Res Int, 70, pp.87~93 (2015)
78. Najmi A, "Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome", Int J Diabetes Dev Ctries, 28(1), pp.11~14 (2008)
79. Hadi S, "Effect of Nigella sativa oil extract on lipid profiles in type 2 diabetic patients : a randomized, double blind, placebo-controlled clinical trial", Iran J Endocrinol Metab, 16(6), pp.411~418 (2015)
80. Akhondian J, "The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures", Med Sci Monit, 13(12), pp.CR555~CR559 (2007)
81. Akhondian J, "The effect of thymoquinone on intractable pediatric seizures (pilot study)", Epilepsy Res, 93(1), pp.39~43 (2011)
82. Shawki M, "The clinical outcome of adjuvant therapy with black seed oil on intractable paediatric seizures: a pilot study", Epileptic Disord, 15(3), pp.295~301 (2013)
83. Bin Sayeed MS, "The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers", J Ethnopharmacol, 148(3), pp.780~786 (2013)
84. Sayeed MS, "Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males", J Ethnopharmacol, 152(1), pp.156~162 (2014)
85. Sangi S, "A new and novel treatment of opioid dependence : Nigella sativa 500 mg", J Ayub Med Coll Abbottabad, 20(2), pp.118~124 (2008)
86. Huseini HF, "Effectiveness of topical Nigella sativa seed oil in the treatment of cyclic mastalgia : a randomized, triple-blind, active, and placebo-controlled clinical trial", Planta Med, 82(4), pp.285~288 (2016)
87. Yousefi M, "Comparison of therapeutic effect of topical Nigella with betamethasone and eucerin in hand eczema", J Eur Acad Dermatol Venereol, 27(12), pp.1498~1504 (2013)
88. Stern T, "Black seed oil ointment-a new approach for the treatment of atopic dermatitis?", Aktuelle Derm, 28(3), pp.74~79 (2002)
89. Bashar T, "A doubleblind, randomize, placebo-control trial to evaluate the effect of Nigella sativa on palmer arsenical keratosis patients", Bangladesh J Pharmacol, 9, pp.15~21 (2014)
90. Abdel-Moneim A, "Beneficial theraputic effects of Nigella sativa and", or Zingiber officinale in HCV patients in Egypt, 2013, pp.12, 943~955
91. Onifade AA, "Nigella sativa concoction induced sustained seroreversion in HIV patient", Afr J Tradit Complement Altern Med, 10(5), pp.332~335 (2013)
92. Onifade AA, "Seronegative conversion of an HIV positive subject treated with Nigella sativa and honey", Afr J Infect Dis, 9(2), pp.47~50 (2015)
93. EM Salem, "Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia", Saudi J Gastroenterol, 16(3), pp.207~214 (2010)
94. Fard FA, "Therapeutic effects of Nigella Sativa Linn (Black Cumin)on Candida albicans vaginitis", Arch Clin Infect Dis, 10(1), pp.e22991~ (2015)
95. Mandavi R, "Effects of black seeds(Nigella sativa)on male infertility : a systematic review", J Herb Med, 5(3), pp.133~139 (2015)
96. Boskabady MH, "Antiasthmatic effect of Nigella sativa in airways of asthmatic patients", Phytomedicine, 17(10), pp.707~713 (2010)
97. Boskabady MH, "The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients", Fundam Clin Pharmacol, 21(5), pp.559~566 (2007)
98. Ahmad J, "A study of Nigella sativa oil in the management of wheeze associated lower respiratory tract illness in children", Afr J Pharm Pharmacol, 3(5), pp.248~251 (2009)
99. Boskabady MH, "The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims : a randomized, double-blind, placebo-controlled trial", J Altern Complement Med, 14(9), pp.1137~1144 (2008)
100. Nikakhlagh S, "Herbal treatment of allergic rhinitis : the use of Nigella sativa", Am J Otolaryngol, 32(5), pp.402~407 (2011)
101. Isik H, "Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients", Med Princ Pract, 19(3), pp.206~211 (2010)
102. Oysu C, "Topical Nigella sativa for nasal symptoms in elderly", Auris Nasus Larynx, 41(3), pp.269~272 (2014)
103. Deurer A, "Effect of black cumin oil on the immune status of patients with inhalation energy", Biol Med, 31, pp.75~78 (2002)
104. Gheita TA, "Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients : a placebo controlled study", Phytother Res, 26(8), pp.1246~1248 (2012)
105. Valizadeh N, "Impact of black seed(Nigella sativa)extract on bone turnover markers in postmenopausal women with osteoporosis", Daru, 1, pp.20~25 (2010)
106. Osman MT, "Immunomodulatory effect of Nigella sativa oil treatment in iron deficiency anemia caused by refractory coeliac disease", Res J Pharm Biol Chem Sci, 3, pp.887~895 (2012)
107. Osman MT, "Immunotherapeutic application of Nigella sativa oil in management of dermatitis herpetiformis associated with refractory coeliac disease", Res J Pharm Biol Chem Sci, 4, pp.1181~1186 (2013)
108. Hagag AA, "Therapeutic value of black seed oil in methotrexate hepatotoxicity in Egyptian children with acute lymphoblastic leukemia", Infect Disord Drug Targets, 15(1), pp.64~71 (2015)
109. Qidwai W, "Effect of dietary supplementation of black seed (N. Sativa L.) on lipid profile of patients suffering from diabetes", Antiinflamm Antiallergy Agents Med Chem, 13(1), pp.3~8 (2014)
110. Kalus U, "Effect of Nigella sativa(black seed)on subjective feeling in patients with allergic diseases", Phytother Res, 17(10), pp.1209~1214 (2003)
111. Esmail F, "The effects of 8-week Nigella sativa supplementation and aerobic training on lipid profile and VO2 max in sedentary overweight females", Int J Prev Med, 5(2), pp.210~216 (2014)

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